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Q1GSA2

- PUR5_SPHAL

UniProt

Q1GSA2 - PUR5_SPHAL

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSALA317655:GHHY-1782-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Sala_1757
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258408Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_1757.

Structurei

3D structure databases

ProteinModelPortaliQ1GSA2.
SMRiQ1GSA2. Positions 10-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiGEATCEV.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GSA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKHNSPAS YTYAQAGVSI ETGNALVRAI APLARATRRP GADADLGGFG
60 70 80 90 100
GFFDLRAAGF ADPLLVAAND GVGTKLKLAI ESGRHDGVGI DLVAMCANDL
110 120 130 140 150
IVQGAEPLFF LDYYATGKLD NDVATAVVAS IAEGCKQAGC ALIGGETAEM
160 170 180 190 200
PGMYSDGDYD LAGFCVGAVE RDRVLTSDKV AAGDVILGLA SSGVHSNGFS
210 220 230 240 250
LVRRLAADKG WKLDRPALFD QTVLLIDALM APTRIYVKSL LPLVKTGKIH
260 270 280 290 300
ALAHITGGGL LENIPRVLPK TLHAHVDADS WEQPRLMAFL QAQGNIEPEE
310 320 330 340 350
MARTFNCGIG MAVVVAEADV ADVTAALEAV GETVFRIGHI AEGERGCTVT
360
GSAETWSARA DWSARHNA
Length:368
Mass (Da):38,518
Last modified:June 27, 2006 - v1
Checksum:i3D05CB209F9636CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53470.1.
RefSeqiWP_011542050.1. NC_008048.1.
YP_616803.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF53470; ABF53470; Sala_1757.
GeneIDi4081992.
KEGGisal:Sala_1757.
PATRICi23692800. VBISphAla23391_1823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53470.1 .
RefSeqi WP_011542050.1. NC_008048.1.
YP_616803.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GSA2.
SMRi Q1GSA2. Positions 10-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_1757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF53470 ; ABF53470 ; Sala_1757 .
GeneIDi 4081992.
KEGGi sal:Sala_1757.
PATRICi 23692800. VBISphAla23391_1823.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi GEATCEV.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SALA317655:GHHY-1782-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.

Entry informationi

Entry nameiPUR5_SPHAL
AccessioniPrimary (citable) accession number: Q1GSA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3