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Q1GRZ2

- GCSPA_SPHAL

UniProt

Q1GRZ2 - GCSPA_SPHAL

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Sala_1868
Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSALA317655:GHHY-1895-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Sala_1868
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045677Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi317655.Sala_1868.

Structurei

3D structure databases

ProteinModelPortaliQ1GRZ2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiLPMHASE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GRZ2-1 [UniParc]FASTAAdd to Basket

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MRYLPLTPDD RAAMLGAIGA SSIDELFADV PAGARLDGPI AGLPMHASEL    50
AVERHMGALA RRNRAAGDGP FFLGAGAYRH HVPASVDHLI QRGEFLTAYT 100
PYQPEIAQGT LQMLFEFQSQ VARLFGTDVA NASMYDGSTA CWEAIVMARR 150
ITRRSKALLS TGLHPHYRSV ARTMAKYTRD VLVDGDPRLE PGTDWAALAG 200
RIDTETSCVV VQYPDILGRI DDMTTLAEAC QTAGALLIAV VTEPVALGLI 250
KSPGEMGADI VVGEGQSLGV GLQFGGPYVG LFACKSKYVR QMPGRLCGET 300
VDANGKRGFV LTLSTREQHI RREKATSNIC TNSGLCALAF SIHMTLLGEA 350
GLRQLATINH GRAKAAATEL AKVPAVSVMN DSFFNEFTLL LPTAARPVVH 400
RLAEQDILGG VSLGRLYPDT AALENGLVVA VTETVTEADI AAFAAALKEV 450
LA 452
Length:452
Mass (Da):48,145
Last modified:June 27, 2006 - v1
Checksum:i77E4241D35B4E318
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53580.1.
RefSeqiYP_616913.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF53580; ABF53580; Sala_1868.
GeneIDi4080183.
KEGGisal:Sala_1868.
PATRICi23693026. VBISphAla23391_1934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53580.1 .
RefSeqi YP_616913.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GRZ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_1868.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF53580 ; ABF53580 ; Sala_1868 .
GeneIDi 4080183.
KEGGi sal:Sala_1868.
PATRICi 23693026. VBISphAla23391_1934.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi LPMHASE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-1895-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.

Entry informationi

Entry nameiGCSPA_SPHAL
AccessioniPrimary (citable) accession number: Q1GRZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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