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Q1GRZ2

- GCSPA_SPHAL

UniProt

Q1GRZ2 - GCSPA_SPHAL

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciSALA317655:GHHY-1895-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Sala_1868
    OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
    Taxonomic identifieri317655 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
    ProteomesiUP000006578: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000045677Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi317655.Sala_1868.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GRZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiLPMHASE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1GRZ2-1 [UniParc]FASTAAdd to Basket

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    MRYLPLTPDD RAAMLGAIGA SSIDELFADV PAGARLDGPI AGLPMHASEL    50
    AVERHMGALA RRNRAAGDGP FFLGAGAYRH HVPASVDHLI QRGEFLTAYT 100
    PYQPEIAQGT LQMLFEFQSQ VARLFGTDVA NASMYDGSTA CWEAIVMARR 150
    ITRRSKALLS TGLHPHYRSV ARTMAKYTRD VLVDGDPRLE PGTDWAALAG 200
    RIDTETSCVV VQYPDILGRI DDMTTLAEAC QTAGALLIAV VTEPVALGLI 250
    KSPGEMGADI VVGEGQSLGV GLQFGGPYVG LFACKSKYVR QMPGRLCGET 300
    VDANGKRGFV LTLSTREQHI RREKATSNIC TNSGLCALAF SIHMTLLGEA 350
    GLRQLATINH GRAKAAATEL AKVPAVSVMN DSFFNEFTLL LPTAARPVVH 400
    RLAEQDILGG VSLGRLYPDT AALENGLVVA VTETVTEADI AAFAAALKEV 450
    LA 452
    Length:452
    Mass (Da):48,145
    Last modified:June 27, 2006 - v1
    Checksum:i77E4241D35B4E318
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF53580.1.
    RefSeqiYP_616913.1. NC_008048.1.

    Genome annotation databases

    EnsemblBacteriaiABF53580; ABF53580; Sala_1868.
    GeneIDi4080183.
    KEGGisal:Sala_1868.
    PATRICi23693026. VBISphAla23391_1934.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF53580.1 .
    RefSeqi YP_616913.1. NC_008048.1.

    3D structure databases

    ProteinModelPortali Q1GRZ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317655.Sala_1868.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF53580 ; ABF53580 ; Sala_1868 .
    GeneIDi 4080183.
    KEGGi sal:Sala_1868.
    PATRICi 23693026. VBISphAla23391_1934.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi LPMHASE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci SALA317655:GHHY-1895-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13593 / LMG 18877 / RB2256.

    Entry informationi

    Entry nameiGCSPA_SPHAL
    AccessioniPrimary (citable) accession number: Q1GRZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3