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Q1GRP6

- Q1GRP6_SPHAL

UniProt

Q1GRP6 - Q1GRP6_SPHAL

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Sala_1964

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSALA317655:GHHY-1994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Sala_1964Imported
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)Imported
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_1964.

Structurei

3D structure databases

ProteinModelPortaliQ1GRP6.
SMRiQ1GRP6. Positions 3-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiPENGEPQ.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GRP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKIKVANPV VELDGDEMTR IIWQWIRERL ILPYLDIDLH YYDLGIEERD
60 70 80 90 100
RTDDKITVEA ANAIKKYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR
110 120 130 140 150
NILGGVVFRE PIVMKNVPRL VPGWTDPIVV GRHAFGDQYK ATDFRVPGPG
160 170 180 190 200
KLRLVFEGED GTLIDEEVFQ FPSSGVAMGM YNLDDSIRDF ARASLNYGLA
210 220 230 240 250
REWPVYLSTK NTILKAYDGR FKDIFEEVFN AEFKVQFDAL GIVYEHRLID
260 270 280 290 300
DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT
310 320 330 340 350
VESEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTGGLKH RGKLDDNAAL
360 370 380 390 400
VKFADDLEKV CVATVESGKM TKDLALLIGP DQNWLTTEGF FEAIVENLDK

KMGA
Length:404
Mass (Da):45,193
Last modified:June 27, 2006 - v1
Checksum:iC9215A8E52304D73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF53676.1.
RefSeqiYP_617009.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF53676; ABF53676; Sala_1964.
GeneIDi4080513.
KEGGisal:Sala_1964.
PATRICi23693230. VBISphAla23391_2035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF53676.1 .
RefSeqi YP_617009.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GRP6.
SMRi Q1GRP6. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_1964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF53676 ; ABF53676 ; Sala_1964 .
GeneIDi 4080513.
KEGGi sal:Sala_1964.
PATRICi 23693230. VBISphAla23391_2035.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi PENGEPQ.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-1994-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RB2256Imported.

Entry informationi

Entry nameiQ1GRP6_SPHAL
AccessioniPrimary (citable) accession number: Q1GRP6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3