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Q1GRP6

- Q1GRP6_SPHAL

UniProt

Q1GRP6 - Q1GRP6_SPHAL

Protein

Isocitrate dehydrogenase [NADP]

Gene

Sala_1964

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSALA317655:GHHY-1994-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Sala_1964Imported
    OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)Imported
    Taxonomic identifieri317655 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
    ProteomesiUP000006578: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi317655.Sala_1964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GRP6.
    SMRiQ1GRP6. Positions 3-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiPENGEPQ.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GRP6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIKVANPV VELDGDEMTR IIWQWIRERL ILPYLDIDLH YYDLGIEERD    50
    RTDDKITVEA ANAIKKYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR 100
    NILGGVVFRE PIVMKNVPRL VPGWTDPIVV GRHAFGDQYK ATDFRVPGPG 150
    KLRLVFEGED GTLIDEEVFQ FPSSGVAMGM YNLDDSIRDF ARASLNYGLA 200
    REWPVYLSTK NTILKAYDGR FKDIFEEVFN AEFKVQFDAL GIVYEHRLID 250
    DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 300
    VESEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTGGLKH RGKLDDNAAL 350
    VKFADDLEKV CVATVESGKM TKDLALLIGP DQNWLTTEGF FEAIVENLDK 400
    KMGA 404
    Length:404
    Mass (Da):45,193
    Last modified:June 27, 2006 - v1
    Checksum:iC9215A8E52304D73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF53676.1.
    RefSeqiWP_011542252.1. NC_008048.1.
    YP_617009.1. NC_008048.1.

    Genome annotation databases

    EnsemblBacteriaiABF53676; ABF53676; Sala_1964.
    GeneIDi4080513.
    KEGGisal:Sala_1964.
    PATRICi23693230. VBISphAla23391_2035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF53676.1 .
    RefSeqi WP_011542252.1. NC_008048.1.
    YP_617009.1. NC_008048.1.

    3D structure databases

    ProteinModelPortali Q1GRP6.
    SMRi Q1GRP6. Positions 3-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317655.Sala_1964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF53676 ; ABF53676 ; Sala_1964 .
    GeneIDi 4080513.
    KEGGi sal:Sala_1964.
    PATRICi 23693230. VBISphAla23391_2035.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi PENGEPQ.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci SALA317655:GHHY-1994-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13593 / LMG 18877 / RB2256Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RB2256Imported.

    Entry informationi

    Entry nameiQ1GRP6_SPHAL
    AccessioniPrimary (citable) accession number: Q1GRP6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3