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Q1GRP6

- Q1GRP6_SPHAL

UniProt

Q1GRP6 - Q1GRP6_SPHAL

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Protein
Isocitrate dehydrogenase [NADP]
Gene
Sala_1964
Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarity
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi308 – 3136NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciSALA317655:GHHY-1994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Sala_1964Imported
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)Imported
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_1964.

Structurei

3D structure databases

ProteinModelPortaliQ1GRP6.
SMRiQ1GRP6. Positions 3-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.
OMAiPENGEPQ.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GRP6-1 [UniParc]FASTAAdd to Basket

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MGKIKVANPV VELDGDEMTR IIWQWIRERL ILPYLDIDLH YYDLGIEERD    50
RTDDKITVEA ANAIKKYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR 100
NILGGVVFRE PIVMKNVPRL VPGWTDPIVV GRHAFGDQYK ATDFRVPGPG 150
KLRLVFEGED GTLIDEEVFQ FPSSGVAMGM YNLDDSIRDF ARASLNYGLA 200
REWPVYLSTK NTILKAYDGR FKDIFEEVFN AEFKVQFDAL GIVYEHRLID 250
DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 300
VESEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTGGLKH RGKLDDNAAL 350
VKFADDLEKV CVATVESGKM TKDLALLIGP DQNWLTTEGF FEAIVENLDK 400
KMGA 404
Length:404
Mass (Da):45,193
Last modified:June 27, 2006 - v1
Checksum:iC9215A8E52304D73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53676.1.
RefSeqiWP_011542252.1. NC_008048.1.
YP_617009.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF53676; ABF53676; Sala_1964.
GeneIDi4080513.
KEGGisal:Sala_1964.
PATRICi23693230. VBISphAla23391_2035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF53676.1 .
RefSeqi WP_011542252.1. NC_008048.1.
YP_617009.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GRP6.
SMRi Q1GRP6. Positions 3-403.
ModBasei Search...

Protein-protein interaction databases

STRINGi 317655.Sala_1964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF53676 ; ABF53676 ; Sala_1964 .
GeneIDi 4080513.
KEGGi sal:Sala_1964.
PATRICi 23693230. VBISphAla23391_2035.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.
OMAi PENGEPQ.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-1994-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RB2256Imported.

Entry informationi

Entry nameiQ1GRP6_SPHAL
AccessioniPrimary (citable) accession number: Q1GRP6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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