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Q1GRP6 (Q1GRP6_SPHAL) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity
Binding site1321Substrate By similarity
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
Q1GRP6 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: C9215A8E52304D73

FASTA40445,193
        10         20         30         40         50         60 
MGKIKVANPV VELDGDEMTR IIWQWIRERL ILPYLDIDLH YYDLGIEERD RTDDKITVEA 

        70         80         90        100        110        120 
ANAIKKYGVG VKCATITPDE ARVEEFGLKK MWKSPNGTIR NILGGVVFRE PIVMKNVPRL 

       130        140        150        160        170        180 
VPGWTDPIVV GRHAFGDQYK ATDFRVPGPG KLRLVFEGED GTLIDEEVFQ FPSSGVAMGM 

       190        200        210        220        230        240 
YNLDDSIRDF ARASLNYGLA REWPVYLSTK NTILKAYDGR FKDIFEEVFN AEFKVQFDAL 

       250        260        270        280        290        300 
GIVYEHRLID DMVASALKWS GKFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VESEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTGGLKH RGKLDDNAAL VKFADDLEKV 

       370        380        390        400 
CVATVESGKM TKDLALLIGP DQNWLTTEGF FEAIVENLDK KMGA 

« Hide

References

[1]"Complete sequence of chromosome of Sphingopyxis alaskensis RB2256."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Chertkov O., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Cavicchioli R., Robb F., Ertan H., Schut F., Ting L.M., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13593 / LMG 18877 / RB2256.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000356 Genomic DNA. Translation: ABF53676.1.
RefSeqYP_617009.1. NC_008048.1.

3D structure databases

ProteinModelPortalQ1GRP6.
SMRQ1GRP6. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING317655.Sala_1964.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF53676; ABF53676; Sala_1964.
GeneID4080513.
KEGGsal:Sala_1964.
PATRIC23693230. VBISphAla23391_2035.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycSALA317655:GHHY-1994-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1GRP6_SPHAL
AccessionPrimary (citable) accession number: Q1GRP6
Entry history
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)