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Q1GRK2 (ADE_SPHAL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Ordered Locus Names:Sala_2009
OrganismSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis) [Complete proteome] [HAMAP]
Taxonomic identifier317655 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Sphingopyxis

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Adenine deaminase HAMAP MF_01962
PRO_1000017709

Sites

Active site2071Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2041Zinc; catalytic By similarity
Metal binding2851Zinc; catalytic By similarity
Binding site2861Substrate By similarity
Site2281Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GRK2 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 9C1C6EB63CFC65D5

FASTA34137,282
        10         20         30         40         50         60 
MPDGFASHEE RAAFIAGLPK AELHLHIEGS LEPELLFEFA RRNRVAIPFA SIDDVRAAYA 

        70         80         90        100        110        120 
FTNLQDFLDI YYQGMGVLHT EQDFFDLTAA YCARANADSV RHIEIFFDPQ GHTARGVAFE 

       130        140        150        160        170        180 
TVITGITRAL DDAEARYGIT SKLILCFLRH LSEAEAEATL DEALPFLGRI AGVGLDSSEV 

       190        200        210        220        230        240 
GHPPAKFERV FARARSLGLK TVAHAGEEGP PEYVREALDL LKVDRIDHGN RSLEDPALVA 

       250        260        270        280        290        300 
RLAASDMTLT VCPLSNLKLC VVDDIADHPL KIMLDADLKA TVNSDDPSYF GGYVNANYQA 

       310        320        330        340 
VADALDLSRD DLVTLARNSF TGSFLSDAEK ARHLAAIDAY A

« Hide

References

[1]"Complete sequence of chromosome of Sphingopyxis alaskensis RB2256."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Munk A.C., Chertkov O., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Cavicchioli R., Robb F., Ertan H., Schut F., Ting L.M., Richardson P.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13593 / LMG 18877 / RB2256.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000356 Genomic DNA. Translation: ABF53720.1.
RefSeqYP_617053.1. NC_008048.1.

3D structure databases

ProteinModelPortalQ1GRK2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4079946.
GenomeReviewsGene locus Sala_2009 in contig CP000356_GR.
KEGGsal:Sala_2009.
NMPDRfig|317655.9.peg.1940.
PATRIC23693334. VBISphAla23391_2087.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG630382.
OMAFGGYVDD.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycSALA317655:SALA_2009-MONOMER.

Family and domain databases

HAMAPMF_01962. Adenine_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADE_SPHAL
AccessionPrimary (citable) accession number: Q1GRK2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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