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Protein

Catalase-peroxidase

Gene

katG

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95Transition state stabilizerUniRule annotation1
Active sitei99Proton acceptorUniRule annotation1
Metal bindingi269Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Sala_2146
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
Proteomesi
  • UP000006578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003549371 – 731Catalase-peroxidaseAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki98 ↔ 227Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-254)UniRule annotation
Cross-linki227 ↔ 254Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ1GR67.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi317655.Sala_2146.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GR67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDQTPIGSG CPVHQPGGVR SLLGRTNKDW WPDMLATEIL TPNGPSNPMG
60 70 80 90 100
EDFDYAKAFK SLDYYALKDD LKALMTDSQP WWPADYGHYG PFFIRMAWHA
110 120 130 140 150
AGTYRTADGR GGANSGQQRF APLDSWPDNG NLDKARRLLW PIKQKYGNKI
160 170 180 190 200
SWADLFILAG NVAIESMGGP VFGFGGGRVD VYEPERDIYW GSEDKWVNQG
210 220 230 240 250
VQTRIDPAKG METIEGPLAA IQMGLIYVNP EGPQGNPHDD EGMARDMKET
260 270 280 290 300
FKRMAMNDEE TVALTAGGHT FGKAHGNGDP SLLGPAPAGS DLAAQGFGWV
310 320 330 340 350
SSHESGGIGE HAVTSGIEGA WTNTPREWTE NYFRLLFDYD YELVKSPAGA
360 370 380 390 400
WQWQPINQKE EDMAPAAWDP GIKVPTMMTT ADMALKRDPA YRAISERFRN
410 420 430 440 450
DHEAFKDAFA RAWFKLTHRD MGPKVRYLGP EVPDEDLIWQ DPIPAGTKPS
460 470 480 490 500
DAEVQAVKDK IAASGLTVSQ LIKTAWASAS TFRKSDFRGG ANGARVRLAP
510 520 530 540 550
QKDWEVNEPA MLARVLDTLD GLRGSLSMAD AIVLGGVVGL EKAIRDAGFN
560 570 580 590 600
VAVPFTGGRG DATQEQTDVE SFEVMEPEAD AFRNYVGKKK LAVKVEEMML
610 620 630 640 650
DKASLLGLSV PEMTVLIGGL RVLGANHGER GHGHFTRRSG QLTNDFFVNL
660 670 680 690 700
LDMTNVWKAV EGSNDQEYVA TDRTTGGETW RATRADLIFG SNSELRAVAE
710 720 730
VYAENGHEEK FVRDFVKAWT KVMNADRFDL A
Length:731
Mass (Da):80,470
Last modified:June 27, 2006 - v1
Checksum:i674F7F4DFC5A5A4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF53855.1.
RefSeqiWP_011542431.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF53855; ABF53855; Sala_2146.
KEGGisal:Sala_2146.
PATRICi23693616. VBISphAla23391_2224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF53855.1.
RefSeqiWP_011542431.1. NC_008048.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi317655.Sala_2146.

Proteomic databases

PRIDEiQ1GR67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF53855; ABF53855; Sala_2146.
KEGGisal:Sala_2146.
PATRICi23693616. VBISphAla23391_2224.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SPHAL
AccessioniPrimary (citable) accession number: Q1GR67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.