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Q1GNP7

- SYL_SPHAL

UniProt

Q1GNP7 - SYL_SPHAL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei623 – 6231ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSALA317655:GHHY-3064-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Sala_3020
    OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
    Taxonomic identifieri317655 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
    ProteomesiUP000006578: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 849849Leucine--tRNA ligasePRO_0000334824Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317655.Sala_3020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GNP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5411"HIGH" regionAdd
    BLAST
    Motifi620 – 6245"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GNP7-1 [UniParc]FASTAAdd to Basket

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    MTRETRFGAL AADARWQKAW EAANSFATTD SGQKPKAYIL EMFPYPSGRI    50
    HMGHVRNYAM GDVLARFKRM TGHDVLHPMG WDAFGMPAEN AAMEKGVHPG 100
    GWTRANIDAM RAQLKRLGLA IDWSRELATC EPDYYGQEQA LFLDLHAAGL 150
    VYRKESYVNW DPVDMTVLAN EQVIDGRGWR SGALVEKKKL SQWFLKITDF 200
    ADELLEGLGS LDKWPDKVRL MQENWIGKSQ GLEFSFKFAG GAPAFAVFTT 250
    RPDTLYGASF AAISPDHPLA EKLAKDSPEL AAFIAECRRQ GTSAEQLETA 300
    EKLGFDTGLA VEHPLDPDWH LPVWVVNYVL MDYGTGAIFG CPAHDQRDLD 350
    FAHKYELPVH RVIADGDETA QHFTGSEAYT GPGKLVNSHF LDGMSIDEAK 400
    AAVITRAEHE GWGKGTTVWR LRDWGVSRQR YWGTPIPFIH CAACGTVPVP 450
    KSQLPVTLPD DVDFSVPGNP LDRHPTWKHV ACPICEGAAL RETDTLDTFV 500
    DSSWYFLRFA SAPTDKPFDP EVIRRWLPVD QYIGGIEHAI LHLLYARFWT 550
    RALNKLGMID IEEPFASLFT QGMVTHETYS RPQGEGLPPL YFTPDEVERG 600
    ADGATLIADG APVEVGRVIK MSKSKKNVVD PDAILDQYGA DAVRWFMLSD 650
    SPPERDLPWS EAGIEGAWRF VQRLWRLFGE TENVGDGGED KGLARKLHQT 700
    IAGVAADIEA LGFNKAVAKI HALANEIEKA KPSATRAEAC AKLILLVAPM 750
    MPHLAEEAWT ALPASQRTTP MVADAAWPAA DPALLIDDEV TIAIQMAGKL 800
    RDTMTVAKGA DKAALEAAAL ARPRIVELLG GAAPKKVIVV PDRLVNILP 849
    Length:849
    Mass (Da):93,674
    Last modified:June 27, 2006 - v1
    Checksum:i5A37DBD21B7297D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF54725.1.
    RefSeqiYP_618058.1. NC_008048.1.

    Genome annotation databases

    EnsemblBacteriaiABF54725; ABF54725; Sala_3020.
    GeneIDi4082852.
    KEGGisal:Sala_3020.
    PATRICi23695418. VBISphAla23391_3114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF54725.1 .
    RefSeqi YP_618058.1. NC_008048.1.

    3D structure databases

    ProteinModelPortali Q1GNP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 317655.Sala_3020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF54725 ; ABF54725 ; Sala_3020 .
    GeneIDi 4082852.
    KEGGi sal:Sala_3020.
    PATRICi 23695418. VBISphAla23391_3114.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SALA317655:GHHY-3064-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13593 / LMG 18877 / RB2256.

    Entry informationi

    Entry nameiSYL_SPHAL
    AccessioniPrimary (citable) accession number: Q1GNP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3