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Q1GNP7

- SYL_SPHAL

UniProt

Q1GNP7 - SYL_SPHAL

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSALA317655:GHHY-3064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Sala_3020
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Leucine--tRNA ligasePRO_0000334824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_3020.

Structurei

3D structure databases

ProteinModelPortaliQ1GNP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionAdd
BLAST
Motifi620 – 6245"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GNP7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRETRFGAL AADARWQKAW EAANSFATTD SGQKPKAYIL EMFPYPSGRI
60 70 80 90 100
HMGHVRNYAM GDVLARFKRM TGHDVLHPMG WDAFGMPAEN AAMEKGVHPG
110 120 130 140 150
GWTRANIDAM RAQLKRLGLA IDWSRELATC EPDYYGQEQA LFLDLHAAGL
160 170 180 190 200
VYRKESYVNW DPVDMTVLAN EQVIDGRGWR SGALVEKKKL SQWFLKITDF
210 220 230 240 250
ADELLEGLGS LDKWPDKVRL MQENWIGKSQ GLEFSFKFAG GAPAFAVFTT
260 270 280 290 300
RPDTLYGASF AAISPDHPLA EKLAKDSPEL AAFIAECRRQ GTSAEQLETA
310 320 330 340 350
EKLGFDTGLA VEHPLDPDWH LPVWVVNYVL MDYGTGAIFG CPAHDQRDLD
360 370 380 390 400
FAHKYELPVH RVIADGDETA QHFTGSEAYT GPGKLVNSHF LDGMSIDEAK
410 420 430 440 450
AAVITRAEHE GWGKGTTVWR LRDWGVSRQR YWGTPIPFIH CAACGTVPVP
460 470 480 490 500
KSQLPVTLPD DVDFSVPGNP LDRHPTWKHV ACPICEGAAL RETDTLDTFV
510 520 530 540 550
DSSWYFLRFA SAPTDKPFDP EVIRRWLPVD QYIGGIEHAI LHLLYARFWT
560 570 580 590 600
RALNKLGMID IEEPFASLFT QGMVTHETYS RPQGEGLPPL YFTPDEVERG
610 620 630 640 650
ADGATLIADG APVEVGRVIK MSKSKKNVVD PDAILDQYGA DAVRWFMLSD
660 670 680 690 700
SPPERDLPWS EAGIEGAWRF VQRLWRLFGE TENVGDGGED KGLARKLHQT
710 720 730 740 750
IAGVAADIEA LGFNKAVAKI HALANEIEKA KPSATRAEAC AKLILLVAPM
760 770 780 790 800
MPHLAEEAWT ALPASQRTTP MVADAAWPAA DPALLIDDEV TIAIQMAGKL
810 820 830 840
RDTMTVAKGA DKAALEAAAL ARPRIVELLG GAAPKKVIVV PDRLVNILP
Length:849
Mass (Da):93,674
Last modified:June 27, 2006 - v1
Checksum:i5A37DBD21B7297D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF54725.1.
RefSeqiWP_011543288.1. NC_008048.1.
YP_618058.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF54725; ABF54725; Sala_3020.
GeneIDi4082852.
KEGGisal:Sala_3020.
PATRICi23695418. VBISphAla23391_3114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000356 Genomic DNA. Translation: ABF54725.1 .
RefSeqi WP_011543288.1. NC_008048.1.
YP_618058.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GNP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_3020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF54725 ; ABF54725 ; Sala_3020 .
GeneIDi 4082852.
KEGGi sal:Sala_3020.
PATRICi 23695418. VBISphAla23391_3114.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-3064-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.

Entry informationi

Entry nameiSYL_SPHAL
AccessioniPrimary (citable) accession number: Q1GNP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3