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Q1GNP7

- SYL_SPHAL

UniProt

Q1GNP7 - SYL_SPHAL

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Protein
Leucine--tRNA ligase
Gene
leuS, Sala_3020
Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei623 – 6231ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSALA317655:GHHY-3064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Sala_3020
OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Taxonomic identifieri317655 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
ProteomesiUP000006578: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Leucine--tRNA ligaseUniRule annotation
PRO_0000334824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi317655.Sala_3020.

Structurei

3D structure databases

ProteinModelPortaliQ1GNP7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5411"HIGH" regionUniRule annotation
Add
BLAST
Motifi620 – 6245"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GNP7-1 [UniParc]FASTAAdd to Basket

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MTRETRFGAL AADARWQKAW EAANSFATTD SGQKPKAYIL EMFPYPSGRI    50
HMGHVRNYAM GDVLARFKRM TGHDVLHPMG WDAFGMPAEN AAMEKGVHPG 100
GWTRANIDAM RAQLKRLGLA IDWSRELATC EPDYYGQEQA LFLDLHAAGL 150
VYRKESYVNW DPVDMTVLAN EQVIDGRGWR SGALVEKKKL SQWFLKITDF 200
ADELLEGLGS LDKWPDKVRL MQENWIGKSQ GLEFSFKFAG GAPAFAVFTT 250
RPDTLYGASF AAISPDHPLA EKLAKDSPEL AAFIAECRRQ GTSAEQLETA 300
EKLGFDTGLA VEHPLDPDWH LPVWVVNYVL MDYGTGAIFG CPAHDQRDLD 350
FAHKYELPVH RVIADGDETA QHFTGSEAYT GPGKLVNSHF LDGMSIDEAK 400
AAVITRAEHE GWGKGTTVWR LRDWGVSRQR YWGTPIPFIH CAACGTVPVP 450
KSQLPVTLPD DVDFSVPGNP LDRHPTWKHV ACPICEGAAL RETDTLDTFV 500
DSSWYFLRFA SAPTDKPFDP EVIRRWLPVD QYIGGIEHAI LHLLYARFWT 550
RALNKLGMID IEEPFASLFT QGMVTHETYS RPQGEGLPPL YFTPDEVERG 600
ADGATLIADG APVEVGRVIK MSKSKKNVVD PDAILDQYGA DAVRWFMLSD 650
SPPERDLPWS EAGIEGAWRF VQRLWRLFGE TENVGDGGED KGLARKLHQT 700
IAGVAADIEA LGFNKAVAKI HALANEIEKA KPSATRAEAC AKLILLVAPM 750
MPHLAEEAWT ALPASQRTTP MVADAAWPAA DPALLIDDEV TIAIQMAGKL 800
RDTMTVAKGA DKAALEAAAL ARPRIVELLG GAAPKKVIVV PDRLVNILP 849
Length:849
Mass (Da):93,674
Last modified:June 27, 2006 - v1
Checksum:i5A37DBD21B7297D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF54725.1.
RefSeqiYP_618058.1. NC_008048.1.

Genome annotation databases

EnsemblBacteriaiABF54725; ABF54725; Sala_3020.
GeneIDi4082852.
KEGGisal:Sala_3020.
PATRICi23695418. VBISphAla23391_3114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000356 Genomic DNA. Translation: ABF54725.1 .
RefSeqi YP_618058.1. NC_008048.1.

3D structure databases

ProteinModelPortali Q1GNP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 317655.Sala_3020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF54725 ; ABF54725 ; Sala_3020 .
GeneIDi 4082852.
KEGGi sal:Sala_3020.
PATRICi 23695418. VBISphAla23391_3114.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SALA317655:GHHY-3064-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13593 / LMG 18877 / RB2256.

Entry informationi

Entry nameiSYL_SPHAL
AccessioniPrimary (citable) accession number: Q1GNP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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