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Q1GNC9

- TRMB_SPHAL

UniProt

Q1GNC9 - TRMB_SPHAL

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, Sala_3140
Organism
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Active sitei141 – 1411 By similarity
Binding sitei141 – 1411S-adenosyl-L-methionine By similarity
Binding sitei145 – 1451Substrate By similarity
Binding sitei177 – 1771Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciSALA317655:GHHY-3182-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:Sala_3140
    OrganismiSphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) (Sphingomonas alaskensis)
    Taxonomic identifieri317655 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingopyxis
    ProteomesiUP000006578: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288231Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi317655.Sala_3140.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GNC9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni216 – 2194Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GNC9-1 [UniParc]FASTAAdd to Basket

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    MTAHKPGDPT TLNRLYGRSK GKPLRAGQQD LVDTLLPQIA VPLDGEVTAR    50
    RLFGFDRPLH FEIGFGGGEH MAARADMLPD HGFIGAEPFI NGVAQALVHV 100
    AGDHGQHPPL GNVRIHHGDA LEVLRRIPDG ALAFVYLLHP DPWPKARHAK 150
    RRMMNDGPLD LIAAKLKPGG EFRFGTDHPI YLRHALMVMR RHRHQFEWLA 200
    KDARDFQVRP GGWPETRYEA KARAQGHEVW YFRWRRR 237
    Length:237
    Mass (Da):26,942
    Last modified:May 29, 2007 - v2
    Checksum:iEA69A60E7C4A03B4
    GO

    Sequence cautioni

    The sequence ABF54843.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF54843.1. Different initiation.
    RefSeqiYP_618176.1. NC_008048.1.

    Genome annotation databases

    EnsemblBacteriaiABF54843; ABF54843; Sala_3140.
    GeneIDi4082396.
    KEGGisal:Sala_3140.
    PATRICi23695658. VBISphAla23391_3234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000356 Genomic DNA. Translation: ABF54843.1 . Different initiation.
    RefSeqi YP_618176.1. NC_008048.1.

    3D structure databases

    ProteinModelPortali Q1GNC9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 317655.Sala_3140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF54843 ; ABF54843 ; Sala_3140 .
    GeneIDi 4082396.
    KEGGi sal:Sala_3140.
    PATRICi 23695658. VBISphAla23391_3234.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci SALA317655:GHHY-3182-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13593 / LMG 18877 / RB2256.

    Entry informationi

    Entry nameiTRMB_SPHAL
    AccessioniPrimary (citable) accession number: Q1GNC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: June 11, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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