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Protein

Aminopyrimidine aminohydrolase

Gene

TM1040_3656

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.UniRule annotation

Catalytic activityi

4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia.UniRule annotation
Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Thiamine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciRSP292414:GHCT-3727-MONOMER.
UniPathwayiUPA00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopyrimidine aminohydrolaseUniRule annotation (EC:3.5.99.2UniRule annotation)
Gene namesi
Ordered Locus Names:TM1040_3656Imported
Encoded oniPlasmid megaplasmid TM1040Imported
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)Imported
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Plasmid megaplasmid TM1040

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVUX-ray1.80A1-225[»]
ProteinModelPortaliQ1GL43.
SMRiQ1GL43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 223TENA_THI-4InterPro annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TenA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225158.
KOiK03707.
OMAiCISHPFV.
OrthoDBiPOG091H07EO.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR04306. salvage_TenA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GL43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPYGKAFS LMRAEAEPAW RAYTHHAFVE GLKAGTLPRE AFLHYLQQDY
60 70 80 90 100
VFLIHFSRAW ALAVVKSETH SEMLAAVGTV NALVAEEMQL HIGICEASGI
110 120 130 140 150
SQEALFATRE RAENLAYTRF VLEAGYSGDL LDLLAALAPC VMGYGEIGKR
160 170 180 190 200
LTAEATSTLY GDWIDTYGGD DYQAACKAVG TLLDDALERR LGAEFTSSPR
210 220
WSRLCQTFHT ATELEVGFWQ MGLTP
Length:225
Mass (Da):24,842
Last modified:June 27, 2006 - v1
Checksum:i89A051E692122F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000376 Genomic DNA. Translation: ABF62623.1.
RefSeqiWP_011537262.1. NC_008043.1.

Genome annotation databases

EnsemblBacteriaiABF62623; ABF62623; TM1040_3656.
KEGGisit:TM1040_3656.
PATRICi23383804. VBIRueSp69653_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000376 Genomic DNA. Translation: ABF62623.1.
RefSeqiWP_011537262.1. NC_008043.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVUX-ray1.80A1-225[»]
ProteinModelPortaliQ1GL43.
SMRiQ1GL43.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi4075625.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF62623; ABF62623; TM1040_3656.
KEGGisit:TM1040_3656.
PATRICi23383804. VBIRueSp69653_0746.

Phylogenomic databases

HOGENOMiHOG000225158.
KOiK03707.
OMAiCISHPFV.
OrthoDBiPOG091H07EO.

Enzyme and pathway databases

UniPathwayiUPA00060.
BioCyciRSP292414:GHCT-3727-MONOMER.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR04306. salvage_TenA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ1GL43_RUEST
AccessioniPrimary (citable) accession number: Q1GL43
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, PlasmidImported, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.