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Protein

Aminopyrimidine aminohydrolase

Gene

TM1040_3656

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.UniRule annotation

Catalytic activityi

4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia.UniRule annotation
Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciRSP292414:GHCT-3727-MONOMER.
UniPathwayiUPA00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopyrimidine aminohydrolaseUniRule annotation (EC:3.5.99.2UniRule annotation)
Gene namesi
Ordered Locus Names:TM1040_3656Imported
Encoded oniPlasmid megaplasmid TM1040Imported
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)Imported
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Plasmid megaplasmid TM1040

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVUX-ray1.80A1-225[»]
ProteinModelPortaliQ1GL43.
SMRiQ1GL43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 223TENA_THI-4InterPro annotationAdd BLAST210

Sequence similaritiesi

Belongs to the TenA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225158.
KOiK03707.
OMAiCISHPFV.
OrthoDBiPOG091H07EO.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiView protein in InterPro
IPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
PfamiView protein in Pfam
PF03070. TENA_THI-4. 1 hit.
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR04306. salvage_TenA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GL43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPYGKAFS LMRAEAEPAW RAYTHHAFVE GLKAGTLPRE AFLHYLQQDY
60 70 80 90 100
VFLIHFSRAW ALAVVKSETH SEMLAAVGTV NALVAEEMQL HIGICEASGI
110 120 130 140 150
SQEALFATRE RAENLAYTRF VLEAGYSGDL LDLLAALAPC VMGYGEIGKR
160 170 180 190 200
LTAEATSTLY GDWIDTYGGD DYQAACKAVG TLLDDALERR LGAEFTSSPR
210 220
WSRLCQTFHT ATELEVGFWQ MGLTP
Length:225
Mass (Da):24,842
Last modified:June 27, 2006 - v1
Checksum:i89A051E692122F6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000376 Genomic DNA. Translation: ABF62623.1.
RefSeqiWP_011537262.1. NC_008043.1.

Genome annotation databases

EnsemblBacteriaiABF62623; ABF62623; TM1040_3656.
KEGGisit:TM1040_3656.

Similar proteinsi

Entry informationi

Entry nameiQ1GL43_RUEST
AccessioniPrimary (citable) accession number: Q1GL43
Entry historyiIntegrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, PlasmidImported, Reference proteomeImported