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Q1GKN8

- SYL_RUEST

UniProt

Q1GKN8 - SYL_RUEST

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP292414:GHCT-45-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TM1040_0045
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857Leucine--tRNA ligasePRO_1000009433Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_0045.

Structurei

3D structure databases

ProteinModelPortaliQ1GKN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi628 – 6325"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GKN8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRYEASDIE ARWQKAWEEA AIFQAKEDHS KPKYYVLEMF PYPSGKLHMG
60 70 80 90 100
HVRNYTMGDV IARYKLSTGH NVLHPMGFDA FGMPAENAAM ASGGHPKDWT
110 120 130 140 150
YSNIDTMVEQ MKPLGLSLDW SRMFATCDPE YYGQQQALFL DFLEKGLVYR
160 170 180 190 200
KNAVVNWDPV DMTVLANEQV ENGRGWRSGA LVERRELTQW FFKISDYSDE
210 220 230 240 250
LLEALDGLEN WPAKVRLMQE NWIGKSRGLQ FSFERTDGEE AIEVYTTRPD
260 270 280 290 300
TLMGASFVGI SPDHPIAKKL EAESQEVADF VAECRKGGTT EEAIETAEKL
310 320 330 340 350
GYDTGLRVKH PLDPNWELPV WIANFILMDY GTGAIFACPA HDQRDFEFAT
360 370 380 390 400
KYNLPIIPVL EPVEGAGELT EAYVPTKAEK VRYVRGFAGD ELQTGEEGVN
410 420 430 440 450
TAVDKAEAEG WGQGVTKFRL RDWGLSRQRY WGCPIPVVHC PDCGVVPEKK
460 470 480 490 500
ENLPIALPYD EDGKAIDFSV PGNPLDRHPS WRNCACPNCG KPAQRETDTM
510 520 530 540 550
DTFVDSSWYF ARFTAPRAET PTDLDAANYW MNVDQYIGGI EHAILHLLYS
560 570 580 590 600
RFFARAMQIC GHLPESAKEP FDALFTQGMV THAIYENAER KDDNGRAIYH
610 620 630 640 650
YPSEVEERDG GVFVKETGER IKVIPSAKMS KSKNNVVDPL AIISTYGADT
660 670 680 690 700
ARWFVLSDSP PERDVEWTAS GAEAAYKHLN RVWNLCDRIG EMDPDAKGEG
710 720 730 740 750
DEELLREMHK AIRDVTLGVE SFGFNAAIAK LYGFTNTLSK SKASAAVQKQ
760 770 780 790 800
AIKTLAQLMS PMTPHLAEDI WAHQGGEGLI ANAAWPVADE SMLVEDSVTL
810 820 830 840 850
PIQVNGKRRG EITVAKDLDK AEVEKLALAH EAVQRVLEGA APKKVIVVPG

RIVNVVA
Length:857
Mass (Da):95,857
Last modified:June 27, 2006 - v1
Checksum:i67FE4D9302BC6DA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF62778.1.
RefSeqiWP_011537416.1. NC_008044.1.
YP_612040.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF62778; ABF62778; TM1040_0045.
GeneIDi4078708.
KEGGisit:TM1040_0045.
PATRICi23384129. VBIRueSp69653_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF62778.1 .
RefSeqi WP_011537416.1. NC_008044.1.
YP_612040.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GKN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_0045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF62778 ; ABF62778 ; TM1040_0045 .
GeneIDi 4078708.
KEGGi sit:TM1040_0045.
PATRICi 23384129. VBIRueSp69653_0907.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RSP292414:GHCT-45-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiSYL_RUEST
AccessioniPrimary (citable) accession number: Q1GKN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3