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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei631ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TM1040_0045
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000094331 – 857Leucine--tRNA ligaseAdd BLAST857

Proteomic databases

PRIDEiQ1GKN8

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_0045

Structurei

3D structure databases

ProteinModelPortaliQ1GKN8
SMRiQ1GKN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi628 – 632"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GKN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYEASDIE ARWQKAWEEA AIFQAKEDHS KPKYYVLEMF PYPSGKLHMG
60 70 80 90 100
HVRNYTMGDV IARYKLSTGH NVLHPMGFDA FGMPAENAAM ASGGHPKDWT
110 120 130 140 150
YSNIDTMVEQ MKPLGLSLDW SRMFATCDPE YYGQQQALFL DFLEKGLVYR
160 170 180 190 200
KNAVVNWDPV DMTVLANEQV ENGRGWRSGA LVERRELTQW FFKISDYSDE
210 220 230 240 250
LLEALDGLEN WPAKVRLMQE NWIGKSRGLQ FSFERTDGEE AIEVYTTRPD
260 270 280 290 300
TLMGASFVGI SPDHPIAKKL EAESQEVADF VAECRKGGTT EEAIETAEKL
310 320 330 340 350
GYDTGLRVKH PLDPNWELPV WIANFILMDY GTGAIFACPA HDQRDFEFAT
360 370 380 390 400
KYNLPIIPVL EPVEGAGELT EAYVPTKAEK VRYVRGFAGD ELQTGEEGVN
410 420 430 440 450
TAVDKAEAEG WGQGVTKFRL RDWGLSRQRY WGCPIPVVHC PDCGVVPEKK
460 470 480 490 500
ENLPIALPYD EDGKAIDFSV PGNPLDRHPS WRNCACPNCG KPAQRETDTM
510 520 530 540 550
DTFVDSSWYF ARFTAPRAET PTDLDAANYW MNVDQYIGGI EHAILHLLYS
560 570 580 590 600
RFFARAMQIC GHLPESAKEP FDALFTQGMV THAIYENAER KDDNGRAIYH
610 620 630 640 650
YPSEVEERDG GVFVKETGER IKVIPSAKMS KSKNNVVDPL AIISTYGADT
660 670 680 690 700
ARWFVLSDSP PERDVEWTAS GAEAAYKHLN RVWNLCDRIG EMDPDAKGEG
710 720 730 740 750
DEELLREMHK AIRDVTLGVE SFGFNAAIAK LYGFTNTLSK SKASAAVQKQ
760 770 780 790 800
AIKTLAQLMS PMTPHLAEDI WAHQGGEGLI ANAAWPVADE SMLVEDSVTL
810 820 830 840 850
PIQVNGKRRG EITVAKDLDK AEVEKLALAH EAVQRVLEGA APKKVIVVPG

RIVNVVA
Length:857
Mass (Da):95,857
Last modified:June 27, 2006 - v1
Checksum:i67FE4D9302BC6DA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA Translation: ABF62778.1
RefSeqiWP_011537416.1, NC_008044.1

Genome annotation databases

EnsemblBacteriaiABF62778; ABF62778; TM1040_0045
KEGGisit:TM1040_0045

Similar proteinsi

Entry informationi

Entry nameiSYL_RUEST
AccessioniPrimary (citable) accession number: Q1GKN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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