Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1GKJ2

- PUR9_RUEST

UniProt

Q1GKJ2 - PUR9_RUEST

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciRSP292414:GHCT-91-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:TM1040_0091
    OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
    Taxonomic identifieri292414 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000000636: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000057915Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292414.TM1040_0091.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GKJ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1GKJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDLHPVRRA LLSVSDKTGL IELGKSLAER GVELLSTGGT AKALRDAGLT    50
    VKDVSEVTGF PEMMDGRVKT LHPMVHGGLL ALRDNDAHVA AMTDHGIGEI 100
    DLLVVNLYPF EAALKRGAAY DEMIENIDIG GPAMIRAAAK NHAFVNVVVD 150
    VEDYGVLLEE LDQNDGQTSF AFRQWLAQNA YARTAAYDAA VSNWMAGAIG 200
    LDAPRRRAFA GQIAQTLRYG ENPHQDAAFY TDGTERVGVA TAEQLQGKEL 250
    SYNNINDTDA AFELVSEFAP EDGPAVAIIK HANPCGVARG ATLLEAYNKA 300
    FDCDRTSAFG GIVALNMPLD AETAEAITQI FTEVVIAPGA SDEAKAIFAA 350
    KKNLRLLITE GLPNPQDAGL TTRQVSGGML VQDKDVGHRA MDDLKVVTEK 400
    APTEEQMADL LFAWKVAKHV KSNAIVYVKD GQTVGVGAGQ MSRVDSATIA 450
    GVKAQRMADA MELPESLAKG SAVASDAFFP FADGLMEAAS NGATCVIQPG 500
    GSMRDDEVIK AANDAGLAMV FTGMRHFRH 529
    Length:529
    Mass (Da):56,292
    Last modified:June 27, 2006 - v1
    Checksum:i9358E2A8E01EA7CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF62824.1.
    RefSeqiWP_011537460.1. NC_008044.1.
    YP_612086.1. NC_008044.1.

    Genome annotation databases

    EnsemblBacteriaiABF62824; ABF62824; TM1040_0091.
    GeneIDi4078757.
    KEGGisit:TM1040_0091.
    PATRICi23384221. VBIRueSp69653_0953.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF62824.1 .
    RefSeqi WP_011537460.1. NC_008044.1.
    YP_612086.1. NC_008044.1.

    3D structure databases

    ProteinModelPortali Q1GKJ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292414.TM1040_0091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF62824 ; ABF62824 ; TM1040_0091 .
    GeneIDi 4078757.
    KEGGi sit:TM1040_0091.
    PATRICi 23384221. VBIRueSp69653_0953.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci RSP292414:GHCT-91-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM1040.

    Entry informationi

    Entry nameiPUR9_RUEST
    AccessioniPrimary (citable) accession number: Q1GKJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3