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Q1GKJ2

- PUR9_RUEST

UniProt

Q1GKJ2 - PUR9_RUEST

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, TM1040_0091
Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRSP292414:GHCT-91-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:TM1040_0091
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000057915Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_0091.

Structurei

3D structure databases

ProteinModelPortaliQ1GKJ2.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GKJ2-1 [UniParc]FASTAAdd to Basket

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MTDLHPVRRA LLSVSDKTGL IELGKSLAER GVELLSTGGT AKALRDAGLT    50
VKDVSEVTGF PEMMDGRVKT LHPMVHGGLL ALRDNDAHVA AMTDHGIGEI 100
DLLVVNLYPF EAALKRGAAY DEMIENIDIG GPAMIRAAAK NHAFVNVVVD 150
VEDYGVLLEE LDQNDGQTSF AFRQWLAQNA YARTAAYDAA VSNWMAGAIG 200
LDAPRRRAFA GQIAQTLRYG ENPHQDAAFY TDGTERVGVA TAEQLQGKEL 250
SYNNINDTDA AFELVSEFAP EDGPAVAIIK HANPCGVARG ATLLEAYNKA 300
FDCDRTSAFG GIVALNMPLD AETAEAITQI FTEVVIAPGA SDEAKAIFAA 350
KKNLRLLITE GLPNPQDAGL TTRQVSGGML VQDKDVGHRA MDDLKVVTEK 400
APTEEQMADL LFAWKVAKHV KSNAIVYVKD GQTVGVGAGQ MSRVDSATIA 450
GVKAQRMADA MELPESLAKG SAVASDAFFP FADGLMEAAS NGATCVIQPG 500
GSMRDDEVIK AANDAGLAMV FTGMRHFRH 529
Length:529
Mass (Da):56,292
Last modified:June 27, 2006 - v1
Checksum:i9358E2A8E01EA7CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF62824.1.
RefSeqiWP_011537460.1. NC_008044.1.
YP_612086.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF62824; ABF62824; TM1040_0091.
GeneIDi4078757.
KEGGisit:TM1040_0091.
PATRICi23384221. VBIRueSp69653_0953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF62824.1 .
RefSeqi WP_011537460.1. NC_008044.1.
YP_612086.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GKJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_0091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF62824 ; ABF62824 ; TM1040_0091 .
GeneIDi 4078757.
KEGGi sit:TM1040_0091.
PATRICi 23384221. VBIRueSp69653_0953.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RSP292414:GHCT-91-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiPUR9_RUEST
AccessioniPrimary (citable) accession number: Q1GKJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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