Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1GKJ2

- PUR9_RUEST

UniProt

Q1GKJ2 - PUR9_RUEST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRSP292414:GHCT-91-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:TM1040_0091
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000057915Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_0091.

Structurei

3D structure databases

ProteinModelPortaliQ1GKJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GKJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDLHPVRRA LLSVSDKTGL IELGKSLAER GVELLSTGGT AKALRDAGLT
60 70 80 90 100
VKDVSEVTGF PEMMDGRVKT LHPMVHGGLL ALRDNDAHVA AMTDHGIGEI
110 120 130 140 150
DLLVVNLYPF EAALKRGAAY DEMIENIDIG GPAMIRAAAK NHAFVNVVVD
160 170 180 190 200
VEDYGVLLEE LDQNDGQTSF AFRQWLAQNA YARTAAYDAA VSNWMAGAIG
210 220 230 240 250
LDAPRRRAFA GQIAQTLRYG ENPHQDAAFY TDGTERVGVA TAEQLQGKEL
260 270 280 290 300
SYNNINDTDA AFELVSEFAP EDGPAVAIIK HANPCGVARG ATLLEAYNKA
310 320 330 340 350
FDCDRTSAFG GIVALNMPLD AETAEAITQI FTEVVIAPGA SDEAKAIFAA
360 370 380 390 400
KKNLRLLITE GLPNPQDAGL TTRQVSGGML VQDKDVGHRA MDDLKVVTEK
410 420 430 440 450
APTEEQMADL LFAWKVAKHV KSNAIVYVKD GQTVGVGAGQ MSRVDSATIA
460 470 480 490 500
GVKAQRMADA MELPESLAKG SAVASDAFFP FADGLMEAAS NGATCVIQPG
510 520
GSMRDDEVIK AANDAGLAMV FTGMRHFRH
Length:529
Mass (Da):56,292
Last modified:June 27, 2006 - v1
Checksum:i9358E2A8E01EA7CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF62824.1.
RefSeqiWP_011537460.1. NC_008044.1.
YP_612086.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF62824; ABF62824; TM1040_0091.
GeneIDi4078757.
KEGGisit:TM1040_0091.
PATRICi23384221. VBIRueSp69653_0953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF62824.1 .
RefSeqi WP_011537460.1. NC_008044.1.
YP_612086.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GKJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_0091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF62824 ; ABF62824 ; TM1040_0091 .
GeneIDi 4078757.
KEGGi sit:TM1040_0091.
PATRICi 23384221. VBIRueSp69653_0953.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RSP292414:GHCT-91-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiPUR9_RUEST
AccessioniPrimary (citable) accession number: Q1GKJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 27, 2006
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3