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Protein

Glutathione synthetase

Gene

gshB

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Pathwayi: glutathione biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glutathione synthetase (gshB)
This subpathway is part of the pathway glutathione biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutathione from L-cysteine and L-glutamate, the pathway glutathione biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processGlutathione biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00142; UER00210

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetaseUniRule annotation
Short name:
GSH-SUniRule annotation
Short name:
GSHaseUniRule annotation
Glutathione synthaseUniRule annotation
Gene namesi
Name:gshBUniRule annotation
Ordered Locus Names:TM1040_0450Imported
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)Imported
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_0450

Structurei

3D structure databases

ProteinModelPortaliQ1GJI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 307ATP-graspInterPro annotationAdd BLAST185

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D7Z Bacteria
COG0189 LUCA
HOGENOMiHOG000265022
KOiK01920
OMAiWMRKDPP
OrthoDBiPOG091H04J6

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00162 GSH_S, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR006284 Glut_synth_pro
IPR004218 GSHS_ATP-bd
IPR004215 GSHS_N
IPR016185 PreATP-grasp_dom_sf
PANTHERiPTHR21621:SF4 PTHR21621:SF4, 1 hit
PfamiView protein in Pfam
PF02955 GSH-S_ATP, 1 hit
PF02951 GSH-S_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01380 glut_syn, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GJI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAFQMDPI MGVDVNADSS FRLAEEAQKR GHELFYYSPD QLAYQEGRIT
60 70 80 90 100
ARGHDMVVQR VEGTPATLGE LREVDLADFD VIWLRQDPPF DMHYITSTHL
110 120 130 140 150
LDRLKGQALV VNDPFWVRNY PEKLLVLNFP DLTPPTTIAR DLETIKAFKA
160 170 180 190 200
KHGDVILKPL YGNGGAGVFR LDANDRNLSS LHELFTGFSR EPLIVQKFLP
210 220 230 240 250
DVSNGDKRVI LVDGEPVGAI NRVPAAGETR SNMHVGGRPE KIGLTERDLE
260 270 280 290 300
ICAAIGPLLK EKGQVFVGID VIGDYLTEIN VTSPTGIQEL ERFNGVNIAE
310
KVWEAIEARV A
Length:311
Mass (Da):34,631
Last modified:June 27, 2006 - v1
Checksum:i8B0A17EB2D73F2AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA Translation: ABF63183.1
RefSeqiWP_011537798.1, NC_008044.1

Genome annotation databases

EnsemblBacteriaiABF63183; ABF63183; TM1040_0450
KEGGisit:TM1040_0450

Entry informationi

Entry nameiQ1GJI3_RUEST
AccessioniPrimary (citable) accession number: Q1GJI3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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