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Q1GI38

- PDXA_RUEST

UniProt

Q1GI38 - PDXA_RUEST

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei132 – 1321SubstrateUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Metal bindingi162 – 1621Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi207 – 2071Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi262 – 2621Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Binding sitei279 – 2791SubstrateUniRule annotation
    Binding sitei288 – 2881SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. NAD binding Source: InterPro
    5. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Cobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

    Enzyme and pathway databases

    BioCyciRSP292414:GHCT-962-MONOMER.
    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:TM1040_0945
    OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
    Taxonomic identifieri292414 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000000636: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3263264-hydroxythreonine-4-phosphate dehydrogenasePRO_1000051519Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi292414.TM1040_0945.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GI38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221592.
    KOiK00097.
    OrthoDBiEOG6GN6ZC.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1GI38-1 [UniParc]FASTAAdd to Basket

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    MTGAPQVIAL SCGEPAGIGP EIAVAAWDQL RADCPFVWIG DPRHLPSSHP    50
    WQPVSAPAEA LQVSADALPV WPLEFAGNTT KGEADPQNAS GVIQSIKTGV 100
    ELVTSGKAAA LCTAPIHKKA LIDGAGFAYP GHTEFLAALG GVDHVVMMLA 150
    SAALRVVPAT IHIPLSAVPE VLTPDHLRRV ITLTDRGLRD QFGLTAPRIA 200
    VTGLNPHAGE GGAMGQEEGD WIEALIREMQ TEGYRLTGPH PADTLFHAAA 250
    RARYDAAIAM YHDQALIPIK TLDFDKGVNV TLGLPFIRTS PDHGTAFDIA 300
    GKGLANPSSL IEALRLAQTM AKTRQP 326
    Length:326
    Mass (Da):34,339
    Last modified:June 27, 2006 - v1
    Checksum:i85584BAFB9B8E179
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF63678.1.
    RefSeqiWP_011538288.1. NC_008044.1.
    YP_612940.1. NC_008044.1.

    Genome annotation databases

    EnsemblBacteriaiABF63678; ABF63678; TM1040_0945.
    GeneIDi4077339.
    KEGGisit:TM1040_0945.
    PATRICi23386010. VBIRueSp69653_1831.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF63678.1 .
    RefSeqi WP_011538288.1. NC_008044.1.
    YP_612940.1. NC_008044.1.

    3D structure databases

    ProteinModelPortali Q1GI38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292414.TM1040_0945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF63678 ; ABF63678 ; TM1040_0945 .
    GeneIDi 4077339.
    KEGGi sit:TM1040_0945.
    PATRICi 23386010. VBIRueSp69653_1831.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221592.
    KOi K00097.
    OrthoDBi EOG6GN6ZC.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .
    BioCyci RSP292414:GHCT-962-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM1040.

    Entry informationi

    Entry nameiPDXA_RUEST
    AccessioniPrimary (citable) accession number: Q1GI38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3