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Q1GH67 (KGUA_RUEST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:TM1040_1266
OrganismRuegeria sp. (strain TM1040) (Silicibacter sp.) [Complete proteome] [HAMAP]
Taxonomic identifier292414 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Guanylate kinase HAMAP-Rule MF_00328
PRO_0000266404

Regions

Domain10 – 190181Guanylate kinase-like
Nucleotide binding17 – 248ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GH67 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 365EC6875795712A

FASTA21724,496
        10         20         30         40         50         60 
MAHSKAQRRG LLIILSSPSG AGKSTLAKRL RAWDSDISFS VSATTRKPRP GEVDGQDYHF 

        70         80         90        100        110        120 
VTVESFKQDV ANGDMLEHAH VFGNFYGSPK GPVQTAINEG RDVLFDIDWQ GAQQITNSDL 

       130        140        150        160        170        180 
GKHTLSIFLL PPSITELRRR LESRGQDDAE TISRRMQKSW DEISHWGSYD HVLINEDLDE 

       190        200        210 
TEEALKTIIT ATRLRRIQQP SLIEHARALQ QEFEDLS 

« Hide

References

[1]"Complete sequence of chromosome of Silicibacter sp. TM1040."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM1040.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000377 Genomic DNA. Translation: ABF63999.1.
RefSeqYP_613261.1. NC_008044.1.

3D structure databases

ProteinModelPortalQ1GH67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292414.TM1040_1266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF63999; ABF63999; TM1040_1266.
GeneID4077660.
KEGGsit:TM1040_1266.
PATRIC23386686. VBIRueSp69653_2164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037638.
KOK00942.
OrthoDBEOG6CP410.
ProtClustDBPRK00300.

Enzyme and pathway databases

BioCycRSP292414:GHCT-1288-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_RUEST
AccessionPrimary (citable) accession number: Q1GH67
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families