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Q1GGK7

- PUR5_RUEST

UniProt

Q1GGK7 - PUR5_RUEST

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSP292414:GHCT-1502-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:TM1040_1476
    OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
    Taxonomic identifieri292414 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000000636: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258406Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292414.TM1040_1476.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GGK7.
    SMRiQ1GGK7. Positions 7-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1GGK7-1 [UniParc]FASTAAdd to Basket

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    MTSGKNGLTY ADAGVDIDAG NELVDRIKPA AKRTNRPGVM SGLGGFGALF    50
    DLKAAGYEDP ILVGATDGVG TKLRIAIDTG LVDGVGIDLV AMCVNDLVCQ 100
    GAEPLFFLDY FATGKLETDV AARIIEGIAE GCVRSGCALI GGETAEMPGM 150
    YPKGDFDLAG FAVGAMERGT ALPAGVSEGD VLLGLASDGV HSNGYSLVRQ 200
    IVKYSGLGWD GDNPFGEGKL GEALLTPTRL YVKQSLAAVR AGGVNALAHI 250
    TGGGLTENLP RVLPDDLGAD IDLGAWELPG VFKWMAQTGG IEESEMLKTF 300
    NCGIGMILVV KADRADALTE VLEGEGETVA RLGTVTRGEG IRYTGALL 348
    Length:348
    Mass (Da):35,929
    Last modified:June 27, 2006 - v1
    Checksum:iE4053F41C370CE14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF64209.1.
    RefSeqiWP_011538811.1. NC_008044.1.
    YP_613471.1. NC_008044.1.

    Genome annotation databases

    EnsemblBacteriaiABF64209; ABF64209; TM1040_1476.
    GeneIDi4077773.
    KEGGisit:TM1040_1476.
    PATRICi23387118. VBIRueSp69653_2377.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF64209.1 .
    RefSeqi WP_011538811.1. NC_008044.1.
    YP_613471.1. NC_008044.1.

    3D structure databases

    ProteinModelPortali Q1GGK7.
    SMRi Q1GGK7. Positions 7-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292414.TM1040_1476.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF64209 ; ABF64209 ; TM1040_1476 .
    GeneIDi 4077773.
    KEGGi sit:TM1040_1476.
    PATRICi 23387118. VBIRueSp69653_2377.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci RSP292414:GHCT-1502-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM1040.

    Entry informationi

    Entry nameiPUR5_RUEST
    AccessioniPrimary (citable) accession number: Q1GGK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3