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Q1GFV4

- TYSY_RUEST

UniProt

Q1GFV4 - TYSY_RUEST

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Protein

Thymidylate synthase

Gene

thyA

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei159 – 1591UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciRSP292414:GHCT-1758-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:TM1040_1729
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Thymidylate synthasePRO_1000000682Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi292414.TM1040_1729.

Structurei

3D structure databases

ProteinModelPortaliQ1GFV4.
SMRiQ1GFV4. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.

Sequencei

Sequence statusi: Complete.

Q1GFV4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQYHDALQH ILDHGVETTD RTGTGTLSCF GMQQRYDLAE GFPLVTTKKL
60 70 80 90 100
HLRSIIHELL WFLSGDTNIR YLKENGVSIW DEWADENGDL GPVYGYQWRK
110 120 130 140 150
FPRLELAEGT LGDEPLYRAG TVDQISELLD MIRKSPDSRR LIVTAWNPGD
160 170 180 190 200
VPDMALPPCH SLWQLRILGG KMHLQLYQRS ADMFLGVPFN IASYALLLHM
210 220 230 240 250
LAHVTGYEVG SFVHTMGDAH IYSNHMEQVK LQLSRSPKSL PQLRIARDVS
260 270
SIFDFKYEDF EILGYDPDPV IKAPVAV
Length:277
Mass (Da):31,557
Last modified:June 27, 2006 - v1
Checksum:i77BCABF9611CC6D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF64462.1.
RefSeqiWP_011539057.1. NC_008044.1.
YP_613724.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF64462; ABF64462; TM1040_1729.
GeneIDi4075793.
KEGGisit:TM1040_1729.
PATRICi23387640. VBIRueSp69653_2635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000377 Genomic DNA. Translation: ABF64462.1 .
RefSeqi WP_011539057.1. NC_008044.1.
YP_613724.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GFV4.
SMRi Q1GFV4. Positions 2-276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_1729.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF64462 ; ABF64462 ; TM1040_1729 .
GeneIDi 4075793.
KEGGi sit:TM1040_1729.
PATRICi 23387640. VBIRueSp69653_2635.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci RSP292414:GHCT-1758-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiTYSY_RUEST
AccessioniPrimary (citable) accession number: Q1GFV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3