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Q1GF96

- GCH4_RUEST

UniProt

Q1GF96 - GCH4_RUEST

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei225 – 2251May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRSP292414:GHCT-1969-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:TM1040_1937
    OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
    Taxonomic identifieri292414 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000000636: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367GTP cyclohydrolase FolE2PRO_0000289521Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292414.TM1040_1937.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GF96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GF96-1 [UniParc]FASTAAdd to Basket

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    MNIHSRDVNE TPDRSDAEQA LAVLRRWAGE ASETEVAQLD PAIARLLPGQ    50
    ELQNYPDLKR QYPDDFDANE SYRATLPDLQ NGPSSLIRGA KEQIQHVGIS 100
    NFRLPIRFHT RDNGDLTLET SVTGTVSLDA EKKGINMSRI MRSFYKHAEK 150
    VFSFDVMEAA LEDYLSDLES GDARLQMRFS FPVKVQSLRS GLSGYQYYDV 200
    ALELVQMAGQ RHRIVHLDYV YSSTCPCSLE LSEHARQARG QLATPHSQRS 250
    VARISVQMEQ DGGCLWFEDL IDHCRRAVPT ETQVMVKRED EQAFAELNAA 300
    NPIFVEDAAR LFCEALQSDA RVGDFRVVAS HQESLHSHDA VSVLTQGTMF 350
    AAPSLDPQLF STLIHRG 367
    Length:367
    Mass (Da):41,242
    Last modified:June 27, 2006 - v1
    Checksum:i7A136D643A257BA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF64670.1.
    RefSeqiWP_011539263.1. NC_008044.1.
    YP_613932.1. NC_008044.1.

    Genome annotation databases

    EnsemblBacteriaiABF64670; ABF64670; TM1040_1937.
    GeneIDi4076888.
    KEGGisit:TM1040_1937.
    PATRICi23388096. VBIRueSp69653_2861.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF64670.1 .
    RefSeqi WP_011539263.1. NC_008044.1.
    YP_613932.1. NC_008044.1.

    3D structure databases

    ProteinModelPortali Q1GF96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292414.TM1040_1937.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF64670 ; ABF64670 ; TM1040_1937 .
    GeneIDi 4076888.
    KEGGi sit:TM1040_1937.
    PATRICi 23388096. VBIRueSp69653_2861.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci RSP292414:GHCT-1969-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM1040.

    Entry informationi

    Entry nameiGCH4_RUEST
    AccessioniPrimary (citable) accession number: Q1GF96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3