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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei225May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:TM1040_1937
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895211 – 367GTP cyclohydrolase FolE2Add BLAST367

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_1937

Structurei

3D structure databases

ProteinModelPortaliQ1GF96
SMRiQ1GF96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q1GF96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIHSRDVNE TPDRSDAEQA LAVLRRWAGE ASETEVAQLD PAIARLLPGQ
60 70 80 90 100
ELQNYPDLKR QYPDDFDANE SYRATLPDLQ NGPSSLIRGA KEQIQHVGIS
110 120 130 140 150
NFRLPIRFHT RDNGDLTLET SVTGTVSLDA EKKGINMSRI MRSFYKHAEK
160 170 180 190 200
VFSFDVMEAA LEDYLSDLES GDARLQMRFS FPVKVQSLRS GLSGYQYYDV
210 220 230 240 250
ALELVQMAGQ RHRIVHLDYV YSSTCPCSLE LSEHARQARG QLATPHSQRS
260 270 280 290 300
VARISVQMEQ DGGCLWFEDL IDHCRRAVPT ETQVMVKRED EQAFAELNAA
310 320 330 340 350
NPIFVEDAAR LFCEALQSDA RVGDFRVVAS HQESLHSHDA VSVLTQGTMF
360
AAPSLDPQLF STLIHRG
Length:367
Mass (Da):41,242
Last modified:June 27, 2006 - v1
Checksum:i7A136D643A257BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA Translation: ABF64670.1
RefSeqiWP_011539263.1, NC_008044.1

Genome annotation databases

EnsemblBacteriaiABF64670; ABF64670; TM1040_1937
KEGGisit:TM1040_1937

Similar proteinsi

Entry informationi

Entry nameiGCH4_RUEST
AccessioniPrimary (citable) accession number: Q1GF96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health