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Q1GF96

- GCH4_RUEST

UniProt

Q1GF96 - GCH4_RUEST

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei225 – 2251May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciRSP292414:GHCT-1969-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:TM1040_1937
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367GTP cyclohydrolase FolE2PRO_0000289521Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_1937.

Structurei

3D structure databases

ProteinModelPortaliQ1GF96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GF96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIHSRDVNE TPDRSDAEQA LAVLRRWAGE ASETEVAQLD PAIARLLPGQ
60 70 80 90 100
ELQNYPDLKR QYPDDFDANE SYRATLPDLQ NGPSSLIRGA KEQIQHVGIS
110 120 130 140 150
NFRLPIRFHT RDNGDLTLET SVTGTVSLDA EKKGINMSRI MRSFYKHAEK
160 170 180 190 200
VFSFDVMEAA LEDYLSDLES GDARLQMRFS FPVKVQSLRS GLSGYQYYDV
210 220 230 240 250
ALELVQMAGQ RHRIVHLDYV YSSTCPCSLE LSEHARQARG QLATPHSQRS
260 270 280 290 300
VARISVQMEQ DGGCLWFEDL IDHCRRAVPT ETQVMVKRED EQAFAELNAA
310 320 330 340 350
NPIFVEDAAR LFCEALQSDA RVGDFRVVAS HQESLHSHDA VSVLTQGTMF
360
AAPSLDPQLF STLIHRG
Length:367
Mass (Da):41,242
Last modified:June 27, 2006 - v1
Checksum:i7A136D643A257BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF64670.1.
RefSeqiWP_011539263.1. NC_008044.1.
YP_613932.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF64670; ABF64670; TM1040_1937.
GeneIDi4076888.
KEGGisit:TM1040_1937.
PATRICi23388096. VBIRueSp69653_2861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF64670.1 .
RefSeqi WP_011539263.1. NC_008044.1.
YP_613932.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GF96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_1937.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF64670 ; ABF64670 ; TM1040_1937 .
GeneIDi 4076888.
KEGGi sit:TM1040_1937.
PATRICi 23388096. VBIRueSp69653_2861.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci RSP292414:GHCT-1969-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiGCH4_RUEST
AccessioniPrimary (citable) accession number: Q1GF96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3