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Q1GF96 (GCH4_RUEST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:TM1040_1937
OrganismRuegeria sp. (strain TM1040) (Silicibacter sp.) [Complete proteome] [HAMAP]
Taxonomic identifier292414 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289521

Sites

Site2251May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GF96 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 7A136D643A257BA2

FASTA36741,242
        10         20         30         40         50         60 
MNIHSRDVNE TPDRSDAEQA LAVLRRWAGE ASETEVAQLD PAIARLLPGQ ELQNYPDLKR 

        70         80         90        100        110        120 
QYPDDFDANE SYRATLPDLQ NGPSSLIRGA KEQIQHVGIS NFRLPIRFHT RDNGDLTLET 

       130        140        150        160        170        180 
SVTGTVSLDA EKKGINMSRI MRSFYKHAEK VFSFDVMEAA LEDYLSDLES GDARLQMRFS 

       190        200        210        220        230        240 
FPVKVQSLRS GLSGYQYYDV ALELVQMAGQ RHRIVHLDYV YSSTCPCSLE LSEHARQARG 

       250        260        270        280        290        300 
QLATPHSQRS VARISVQMEQ DGGCLWFEDL IDHCRRAVPT ETQVMVKRED EQAFAELNAA 

       310        320        330        340        350        360 
NPIFVEDAAR LFCEALQSDA RVGDFRVVAS HQESLHSHDA VSVLTQGTMF AAPSLDPQLF 


STLIHRG 

« Hide

References

[1]"Complete sequence of chromosome of Silicibacter sp. TM1040."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM1040.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000377 Genomic DNA. Translation: ABF64670.1.
RefSeqYP_613932.1. NC_008044.1.

3D structure databases

ProteinModelPortalQ1GF96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292414.TM1040_1937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF64670; ABF64670; TM1040_1937.
GeneID4076888.
KEGGsit:TM1040_1937.
PATRIC23388096. VBIRueSp69653_2861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycRSP292414:GHCT-1969-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_RUEST
AccessionPrimary (citable) accession number: Q1GF96
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways