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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Proton acceptorUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciRSP292414:GHCT-1992-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:TM1040_1960
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Ribose-5-phosphate isomerase APRO_1000017001Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi292414.TM1040_1960.

Structurei

3D structure databases

ProteinModelPortaliQ1GF74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 364Substrate bindingUniRule annotation
Regioni89 – 924Substrate bindingUniRule annotation
Regioni102 – 1054Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GF74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDLSPIDK AKFVAAKRAA ELVEDGMRVG LGTGSTAAWL VRCLGEMVRE
60 70 80 90 100
DGLKITGVPT SARTAELARE VGIELITLDE ARWLDLTIDG ADEFDSELNL
110 120 130 140 150
IKGGGGALLQ EKIVATASDQ MVVIADKAKE VETLGAFPLP IEVIPFGWQT
160 170 180 190 200
SQALVEETLI SMDVMGRSST LRMNGASPYV TDEGNHILDL HLNRIGNPRQ
210 220 230 240 250
LALVLNQIPG VVENGLFIDI CDTVVIGYGD GKVEVRDINE GTIETDRIDF
260
VETDNLFADL ND
Length:262
Mass (Da):28,239
Last modified:June 27, 2006 - v1
Checksum:i7F09CA7142F572AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF64692.1.
RefSeqiWP_011539285.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF64692; ABF64692; TM1040_1960.
KEGGisit:TM1040_1960.
PATRICi23388146. VBIRueSp69653_2886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF64692.1.
RefSeqiWP_011539285.1. NC_008044.1.

3D structure databases

ProteinModelPortaliQ1GF74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi292414.TM1040_1960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF64692; ABF64692; TM1040_1960.
KEGGisit:TM1040_1960.
PATRICi23388146. VBIRueSp69653_2886.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiPOG091H059I.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciRSP292414:GHCT-1992-MONOMER.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_RUEST
AccessioniPrimary (citable) accession number: Q1GF74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.