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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:TM1040_2020
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
Proteomesi
  • UP000000636 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei168 – 188HelicalUniRule annotationAdd BLAST21
Transmembranei199 – 219HelicalUniRule annotationAdd BLAST21
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000030661 – 360Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST360

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_2020.

Structurei

3D structure databases

SMRiQ1GF14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GF14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYWLTALSD GGDFFNLFRY ITFRAGGAFL TALIFGFVFG KPLINVLRKR
60 70 80 90 100
QGKGQPIRDD GPEAHLAKVG TPTMGGLLIV GALLFSTLMW ARWDNPFVWL
110 120 130 140 150
VLFVTMSFGL IGFADDYAKV SKQNTSGVSG KVRLLLGFVI AIVAALWASW
160 170 180 190 200
NHPAELQNQL AMPVFKDVLL NLGYLYVPFC ICVIVGAANA VNLTDGLDGL
210 220 230 240 250
AIMPVMIAAG TLGIIAYAVG RVDFSEYLDV HYVPGTGEIL IFTSALFGGG
260 270 280 290 300
LGFLWYNAPP AAVFMGDTGS LALGGALGAI AISTKHELVL AIVGGLFVVE
310 320 330 340 350
ALSVIIQVLY FKRTGRRVFL MAPIHHHYEK KGWAEPTIVI RFWIISLILA
360
MIGLATLKVR
Length:360
Mass (Da):39,017
Last modified:June 27, 2006 - v1
Checksum:i8877861167F53BCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF64752.1.
RefSeqiWP_011539345.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF64752; ABF64752; TM1040_2020.
KEGGisit:TM1040_2020.

Similar proteinsi

Entry informationi

Entry nameiMRAY_RUEST
AccessioniPrimary (citable) accession number: Q1GF14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families