Q1GET3 (HIS8_SILST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	TM1040_2101

Organism

Silicibacter sp. (strain TM1040) [Complete proteome] [HAMAP]

Taxonomic identifier

292414 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Ruegeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000063501
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1GET3 [UniParc]. Last modified June 27, 2006. Version 1. Checksum: 7E259A0F65CFE1E0	FASTA	362	38,383
	10 20 30 40 50 60 MTQITPQPGI MDIALYQGGA AHVDGVSNVT KLSSNENPLG PSPAAVEAMA EAAATMHRYP 70 80 90 100 110 120 SSDHATLRAA IAETHGLDAE RIICGAGSDE IIAFLCQCYA GPGDEVLYTE HGFAMYRISA 130 140 150 160 170 180 LAAGATPVEV KERERVTDVD ALLAGCTAQT KLVFIANPNN PTGTMISEAE VARLADGIPE 190 200 210 220 230 240 DAILVLDGAY AEYVEGFDAG AQLIAARHNV VMTRTFSKIY GLGGARVGWA YGPQEIIDVL 250 260 270 280 290 300 NRVRGPFNVS TTALAGAEAA VRDTDYVQRC RLENAKWRGW LADQLAELGV PSDTSCTNFI 310 320 330 340 350 360 LARFASQSEA ESCDDFLKQR GLIVRRVAGY NLPTALRITI GDETACRAVA AAVKDFKAGA AE

References

[1]

"Complete sequence of chromosome of Silicibacter sp. TM1040." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S., Gilna P. , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TM1040.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000377 Genomic DNA. Translation: ABF64833.1.
RefSeq	YP_614095.1. NC_008044.1.
3D structure databases
ProteinModelPortal	Q1GET3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1GET3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4077852.
GenomeReviews	Gene locus TM1040_2101 in contig CP000377_GR.
KEGG	sit:TM1040_2101.
NMPDR	fig|292414.1.peg.468.
PATRIC	23388436. VBIRueSp69653_3027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0079.
HOGENOM	HBG646350.
OMA	YPSTDHA.
ProtClustDB	PRK02731.
Enzyme and pathway databases
BioCyc	SSP292414:TM1040_2101-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_SILST

Accession

Primary (citable) accession number: Q1GET3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program