ID   Q1GER0_RUEST            Unreviewed;       516 AA.
AC   Q1GER0;
DT   27-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   27-JUN-2006, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABF64856.1};
GN   OrderedLocusNames=TM1040_2124 {ECO:0000313|EMBL:ABF64856.1};
OS   Ruegeria sp. (strain TM1040) (Silicibacter sp.).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Ruegeria.
OX   NCBI_TaxID=292414 {ECO:0000313|EMBL:ABF64856.1, ECO:0000313|Proteomes:UP000000636};
RN   [1] {ECO:0000313|Proteomes:UP000000636}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM1040 {ECO:0000313|Proteomes:UP000000636};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Silicibacter sp. TM1040.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABF64856.1, ECO:0000313|Proteomes:UP000000636}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM1040 {ECO:0000313|EMBL:ABF64856.1,
RC   ECO:0000313|Proteomes:UP000000636};
RX   PubMed=17526795; DOI=10.1128/AEM.02580-06;
RA   Moran M.A., Belas R., Schell M.A., Gonzalez J.M., Sun F., Sun S.,
RA   Binder B.J., Edmonds J., Ye W., Orcutt B., Howard E.C., Meile C.,
RA   Palefsky W., Goesmann A., Ren Q., Paulsen I., Ulrich L.E., Thompson L.S.,
RA   Saunders E., Buchan A.;
RT   "Ecological genomics of marine Roseobacters.";
RL   Appl. Environ. Microbiol. 73:4559-4569(2007).
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DR   EMBL; CP000377; ABF64856.1; -; Genomic_DNA.
DR   RefSeq; WP_011539448.1; NC_008044.1.
DR   AlphaFoldDB; Q1GER0; -.
DR   STRING; 292414.TM1040_2124; -.
DR   KEGG; sit:TM1040_2124; -.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_523442_0_0_5; -.
DR   OrthoDB; 9789782at2; -.
DR   Proteomes; UP000000636; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR021796; Tll0287-like.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF11845; DUF3365; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000636};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          292..427
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   516 AA;  57299 MW;  986FE8EBC0140310 CRC64;
     MKITRRIGRF LVNQPHLINW GIGAAIVALP VVVWMDLMAI TDQSLRRQGQ ALDAVLDTVR
     SYYARNVIGR LNPDGSTFAT HDYHDRDGAI PIPATMAIEL GDQIGTHGLN VQYRFASDYP
     FHGRETTELT WAEDHALSRF REGVDDHYLF YRGEESGLLT HAVTMITPVV MEEACVACHN
     NHSDSPKTDW AVGDIRGVQS YSIVQPVAVS LFSFSHLLAY MVVAGGFGAF FALHQLRLAQ
     RFRKISEELS SNNEFLAGIS MKISRYLSPQ VYRSIFSGEK DASISTERKK LTVFFSDIKD
     FTQTAETLQP EELTALLNEY FTEMSAIAAK HGATIDKFIG DAIVAFFGDP ETLGTAEDAR
     ACVRMALEMQ ERLRELEKEW RARGIDRPFR ARIGINTGYC NVGNFGSEER MDYTIIGAEA
     NLAARLEAAA EPGGIVMSHE TYAHVRDFVA ATPMPPMQFK GITRDVHPYA IAPGQSGNLP
     PTETSMDGKS LTVHLERLDD TTRAQLEAIL GKPLKG
//