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Q1GE26

- FTHS_RUEST

UniProt

Q1GE26 - FTHS_RUEST

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSP292414:GHCT-2398-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TM1040_2358
    OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
    Taxonomic identifieri292414 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
    ProteomesiUP000000636: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300542Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi292414.TM1040_2358.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GE26.
    SMRiQ1GE26. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GE26-1 [UniParc]FASTAAdd to Basket

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    MSYKSDIEIA RAANKLPIQE IGAKLGMKND DLLPYGHDKA KVSQEFINSV    50
    QGNEDGKLVL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL 100
    GPNFGMKGGA AGGGMAQVVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI 150
    YWGNEQEIDI RRVAWRRVVD MNDRALRQIT ASLGGVSNGF PRETGFDITV 200
    ASEVMAILCL ANDLKDLEKR LGDIIVAYRR DKTPVYCRDI KAEGAMTVLL 250
    KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE 300
    AGFGADLGAE KFMNIKCRKA GIAPSAVVVV ATVRAMKMNG GVAKADLGAE 350
    NVEAVKNGCA NLGRHIENVK SFGVPAVVAI NHFVTDTDAE INAVKEYVAS 400
    HGVEAILSRH WELGSEGSAP LAEKVVELVE GGGANFGPLY PDEMPLFEKI 450
    ETIAKRIYRA DEVLADAKIR NQLKEWEEAG YGHLPVCMAK TQYSFSTDPN 500
    LRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRT PAAESICLNE 550
    EGLIEGLF 558
    Length:558
    Mass (Da):59,751
    Last modified:June 27, 2006 - v1
    Checksum:i5A351453974993E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF65090.1.
    RefSeqiWP_011539678.1. NC_008044.1.
    YP_614352.1. NC_008044.1.

    Genome annotation databases

    EnsemblBacteriaiABF65090; ABF65090; TM1040_2358.
    GeneIDi4076477.
    KEGGisit:TM1040_2358.
    PATRICi23388974. VBIRueSp69653_3293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000377 Genomic DNA. Translation: ABF65090.1 .
    RefSeqi WP_011539678.1. NC_008044.1.
    YP_614352.1. NC_008044.1.

    3D structure databases

    ProteinModelPortali Q1GE26.
    SMRi Q1GE26. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 292414.TM1040_2358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF65090 ; ABF65090 ; TM1040_2358 .
    GeneIDi 4076477.
    KEGGi sit:TM1040_2358.
    PATRICi 23388974. VBIRueSp69653_3293.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RSP292414:GHCT-2398-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TM1040.

    Entry informationi

    Entry nameiFTHS_RUEST
    AccessioniPrimary (citable) accession number: Q1GE26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3