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Q1GE26 (FTHS_RUEST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TM1040_2358
OrganismRuegeria sp. (strain TM1040) (Silicibacter sp.) [Complete proteome] [HAMAP]
Taxonomic identifier292414 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300542

Regions

Nucleotide binding67 – 748ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GE26 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 5A351453974993E2

FASTA55859,751
        10         20         30         40         50         60 
MSYKSDIEIA RAANKLPIQE IGAKLGMKND DLLPYGHDKA KVSQEFINSV QGNEDGKLVL 

        70         80         90        100        110        120 
VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL GPNFGMKGGA AGGGMAQVVP 

       130        140        150        160        170        180 
MEEMNLHFTG DFHAITSAHS LLSAMIDNHI YWGNEQEIDI RRVAWRRVVD MNDRALRQIT 

       190        200        210        220        230        240 
ASLGGVSNGF PRETGFDITV ASEVMAILCL ANDLKDLEKR LGDIIVAYRR DKTPVYCRDI 

       250        260        270        280        290        300 
KAEGAMTVLL KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE 

       310        320        330        340        350        360 
AGFGADLGAE KFMNIKCRKA GIAPSAVVVV ATVRAMKMNG GVAKADLGAE NVEAVKNGCA 

       370        380        390        400        410        420 
NLGRHIENVK SFGVPAVVAI NHFVTDTDAE INAVKEYVAS HGVEAILSRH WELGSEGSAP 

       430        440        450        460        470        480 
LAEKVVELVE GGGANFGPLY PDEMPLFEKI ETIAKRIYRA DEVLADAKIR NQLKEWEEAG 

       490        500        510        520        530        540 
YGHLPVCMAK TQYSFSTDPN LRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRT 

       550 
PAAESICLNE EGLIEGLF 

« Hide

References

[1]"Complete sequence of chromosome of Silicibacter sp. TM1040."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Goodwin L., Thompson L.S., Gilna P. expand/collapse author list , Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Belas R., Moran M.A., Buchan A., Gonzalez J.M., Schell M.A., Sun F., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TM1040.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000377 Genomic DNA. Translation: ABF65090.1.
RefSeqYP_614352.1. NC_008044.1.

3D structure databases

ProteinModelPortalQ1GE26.
SMRQ1GE26. Positions 6-556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING292414.TM1040_2358.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF65090; ABF65090; TM1040_2358.
GeneID4076477.
KEGGsit:TM1040_2358.
PATRIC23388974. VBIRueSp69653_3293.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycRSP292414:GHCT-2398-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_RUEST
AccessionPrimary (citable) accession number: Q1GE26
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 27, 2006
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways