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Q1GE26

- FTHS_RUEST

UniProt

Q1GE26 - FTHS_RUEST

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Ruegeria sp. (strain TM1040) (Silicibacter sp.)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSP292414:GHCT-2398-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TM1040_2358
OrganismiRuegeria sp. (strain TM1040) (Silicibacter sp.)
Taxonomic identifieri292414 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRuegeria
ProteomesiUP000000636: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_0000300542Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi292414.TM1040_2358.

Structurei

3D structure databases

ProteinModelPortaliQ1GE26.
SMRiQ1GE26. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GE26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYKSDIEIA RAANKLPIQE IGAKLGMKND DLLPYGHDKA KVSQEFINSV
60 70 80 90 100
QGNEDGKLVL VTAINPTPAG EGKTTTTVGL GDGLNRIGKN AMICIREASL
110 120 130 140 150
GPNFGMKGGA AGGGMAQVVP MEEMNLHFTG DFHAITSAHS LLSAMIDNHI
160 170 180 190 200
YWGNEQEIDI RRVAWRRVVD MNDRALRQIT ASLGGVSNGF PRETGFDITV
210 220 230 240 250
ASEVMAILCL ANDLKDLEKR LGDIIVAYRR DKTPVYCRDI KAEGAMTVLL
260 270 280 290 300
KDAMQPNLVQ TLENNPAFVH GGPFANIAHG CNSVIATKTA LKVADYVVTE
310 320 330 340 350
AGFGADLGAE KFMNIKCRKA GIAPSAVVVV ATVRAMKMNG GVAKADLGAE
360 370 380 390 400
NVEAVKNGCA NLGRHIENVK SFGVPAVVAI NHFVTDTDAE INAVKEYVAS
410 420 430 440 450
HGVEAILSRH WELGSEGSAP LAEKVVELVE GGGANFGPLY PDEMPLFEKI
460 470 480 490 500
ETIAKRIYRA DEVLADAKIR NQLKEWEEAG YGHLPVCMAK TQYSFSTDPN
510 520 530 540 550
LRGAPTGHSV PVREVRLSAG AGFIVVVCGE IMTMPGLPRT PAAESICLNE

EGLIEGLF
Length:558
Mass (Da):59,751
Last modified:June 27, 2006 - v1
Checksum:i5A351453974993E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF65090.1.
RefSeqiWP_011539678.1. NC_008044.1.
YP_614352.1. NC_008044.1.

Genome annotation databases

EnsemblBacteriaiABF65090; ABF65090; TM1040_2358.
GeneIDi4076477.
KEGGisit:TM1040_2358.
PATRICi23388974. VBIRueSp69653_3293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000377 Genomic DNA. Translation: ABF65090.1 .
RefSeqi WP_011539678.1. NC_008044.1.
YP_614352.1. NC_008044.1.

3D structure databases

ProteinModelPortali Q1GE26.
SMRi Q1GE26. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 292414.TM1040_2358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF65090 ; ABF65090 ; TM1040_2358 .
GeneIDi 4076477.
KEGGi sit:TM1040_2358.
PATRICi 23388974. VBIRueSp69653_3293.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSP292414:GHCT-2398-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TM1040.

Entry informationi

Entry nameiFTHS_RUEST
AccessioniPrimary (citable) accession number: Q1GE26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 27, 2006
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3