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Protein

Uridine kinase

Gene

udk1

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + cytidine = ADP + CMP.UniRule annotationSAAS annotation
ATP + uridine = ADP + UMP.UniRule annotationSAAS annotation

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine kinase (udk1), Uridine kinase (udk2)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine kinase (udk1), Uridine kinase (udk2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine kinaseUniRule annotationSAAS annotation (EC:2.7.1.48UniRule annotationSAAS annotation)
Alternative name(s):
Cytidine monophosphokinaseUniRule annotation
Uridine monophosphokinaseUniRule annotation
Gene namesi
Name:udk1Imported
Synonyms:udkUniRule annotation
Ordered Locus Names:Ldb0516Imported
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / JCM 1002 / NBRC 13953 / NCIMB 11778)Imported
Taxonomic identifieri390333 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001259 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi390333.Ldb0516.

Structurei

3D structure databases

ProteinModelPortaliQ1GBC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 195PRKInterPro annotationAdd BLAST187

Sequence similaritiesi

Belongs to the uridine kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DBI. Bacteria.
COG0572. LUCA.
HOGENOMiHOG000262756.
KOiK00876.
OMAiTTLKPMH.

Family and domain databases

CDDicd02023. UMPK. 1 hit.
HAMAPiMF_00551. Uridine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR000764. Uridine_kinase-like.
IPR026008. Uridine_kinase_.
PfamiView protein in Pfam
PF00485. PRK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1GBC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKQHPIII GIAGGSGSGK TTIAHELYDQ FKTDRIRIIT EDSYYKNHPE
60 70 80 90 100
MSMAERNKIN FDHPDAFDTE LLISQLQDLL NGKAIEMPIY DFTTHLRSPE
110 120 130 140 150
TVHVEPADII ILEGILVLAS EELRNLMDIK IFVDTDDDIR LIRRQRRDMA
160 170 180 190 200
ERGRSFDSII DQYLATVKPS YHQFVEPSKR YANIIVPEGG ANDVALDMLI
210
TKVRDILRRN DLAEKEA
Length:217
Mass (Da):24,866
Last modified:June 27, 2006 - v1
Checksum:i5413C0746D7A734B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954253 Genomic DNA. Translation: CAI97347.1.
RefSeqiWP_003622588.1. NZ_JQAV01000001.1.

Genome annotation databases

EnsemblBacteriaiCAI97347; CAI97347; Ldb0516.
GeneIDi4083866.
KEGGildb:Ldb0516.
PATRICifig|390333.13.peg.281.

Similar proteinsi

Entry informationi

Entry nameiQ1GBC1_LACDA
AccessioniPrimary (citable) accession number: Q1GBC1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 27, 2006
Last sequence update: June 27, 2006
Last modified: August 30, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported