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Q1GB63

- UPPP_LACDA

UniProt

Q1GB63 - UPPP_LACDA

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciLDEL390333:GIXG-583-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:Ldb0587
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
    Taxonomic identifieri390333 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001259: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Undecaprenyl-diphosphatasePRO_0000250240Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi390333.Ldb0587.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalUniRule annotationAdd
    BLAST
    Transmembranei43 – 6321HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13121HelicalUniRule annotationAdd
    BLAST
    Transmembranei161 – 18121HelicalUniRule annotationAdd
    BLAST
    Transmembranei186 – 20621HelicalUniRule annotationAdd
    BLAST
    Transmembranei225 – 24521HelicalUniRule annotationAdd
    BLAST
    Transmembranei255 – 27521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1GB63-1 [UniParc]FASTAAdd to Basket

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    MLDIFKAIIL GIIEGVTEFL PISSTGHLYL ADYIIKLDQP TSFINMFMVV    50
    IQLGAILSVI VIYFNKLNPF APSKSKREKG QTWQIWFKVI AAVLPSIIIG 100
    LPLNDWLEEN MTSWQVISAT LIIYGILFIV LENYYAKRQP SLTDLNKMSN 150
    KTALLIGCFQ VLSMIPGTSR SGATILGAML IGSSRYVATE FSFFLAIPTM 200
    FGASLLKLVK FFKAGHVFVG NQLAILLVGM VVSFIVAYLS IKFLLKYVQT 250
    HDFKPFGWYR IVLGIIVTIC GLVFA 275
    Length:275
    Mass (Da):30,670
    Last modified:June 27, 2006 - v1
    Checksum:i1DA86A3C310A1584
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI97417.1.
    RefSeqiYP_618677.1. NC_008054.1.

    Genome annotation databases

    EnsemblBacteriaiCAI97417; CAI97417; Ldb0587.
    GeneIDi4083869.
    KEGGildb:Ldb0587.
    PATRICi22216781. VBILacDel123523_0537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI97417.1 .
    RefSeqi YP_618677.1. NC_008054.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390333.Ldb0587.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI97417 ; CAI97417 ; Ldb0587 .
    GeneIDi 4083869.
    KEGGi ldb:Ldb0587.
    PATRICi 22216781. VBILacDel123523_0537.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci LDEL390333:GIXG-583-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11842 / DSM 20081.

    Entry informationi

    Entry nameiUPPP_LACDA
    AccessioniPrimary (citable) accession number: Q1GB63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3