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Q1GAY0 (G6PI_LACDA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:Ldb0692
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081) [Complete proteome] [HAMAP]
Taxonomic identifier390333 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000252626

Sites

Active site2881Proton donor By similarity
Active site3091 By similarity
Active site4231 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1GAY0 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: 680367D4B654CDF9

FASTA44649,288
        10         20         30         40         50         60 
MNSVVSFDSS KLTPFVHENE LKEMQAMVNA ADKELREGTG AGNDFRGWLD LPVDYDKDEF 

        70         80         90        100        110        120 
ARIKKAAKKI QSDSDVLIGI GIGGSYLGAQ AAIEFLNSSF YMAEKSDYPK VVFCGNSLSG 

       130        140        150        160        170        180 
TYLSDLINWL GDKDFSLNII SKSGTTTEPS VAFRVLKAKL IEKYGKEEAA KRIYATTDRQ 

       190        200        210        220        230        240 
KGALKIEADA EGYEEFVVPD DVGGRFSVLS AVGLLPIAAA GCDIDALMQG AADARAAYTD 

       250        260        270        280        290        300 
PDVSKDSPYQ YAALRNILYR KGYTTELLEN YEPSIRMFGE WWKQLMGESE GKDQKGIYPS 

       310        320        330        340        350        360 
SANFTTDLHS LGQYIQEGRR NLMETVVRVA GPRADVEIPN DESNLDQLNF LAGKKMNYVN 

       370        380        390        400        410        420 
DRAYEGVVLA HTDGGVPVMT VNIADQSEHT LGYLIYWFEL SVAISGYLNG INPFNQPGVE 

       430        440 
AYKRNMFGLL NKPGYEDLHD ELASRL 

« Hide

References

[1]"The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution."
van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P., Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R., Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P. expand/collapse author list , Weissenbach J., Ehrlich S.D., Maguin E.
Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 11842 / DSM 20081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR954253 Genomic DNA. Translation: CAI97521.1.
RefSeqYP_618760.1. NC_008054.1.

3D structure databases

ProteinModelPortalQ1GAY0.
SMRQ1GAY0. Positions 5-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390333.Ldb0692.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI97521; CAI97521; Ldb0692.
GeneID4085051.
KEGGldb:Ldb0692.
PATRIC22216987. VBILacDel123523_0639.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100403.
KOK01810.
OMAQVIFIGN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycLDEL390333:GIXG-688-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_LACDA
AccessionPrimary (citable) accession number: Q1GAY0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 27, 2006
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways