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Q1GA94

- FTHS_LACDA

UniProt

Q1GA94 - FTHS_LACDA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLDEL390333:GIXG-1008-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Ldb1020
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
    Taxonomic identifieri390333 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001259: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Formate--tetrahydrofolate ligasePRO_0000293039Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi390333.Ldb1020.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1GA94.
    SMRiQ1GA94. Positions 5-557.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1GA94-1 [UniParc]FASTAAdd to Basket

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    MVKSDIEIAQ AAEELPITDV AAKLGLTSQD LEPYGYDKAK VNWQAIKRSE    50
    ENGHLGKLIL VTSISPTPAG EGKSTMTIGI GDAINNQLGK KTVIALREPS 100
    MGPVFGMKGG AAGGGYAQVI PMEDINLHFT GDMHALTSAI DNLSALVDNY 150
    IYQGNELGLD PEKIVIKRGL DVNDRTLRKV TIGQGSKFNG VERPASFQLT 200
    VGHELMAILC LSKDIADLKE RIGKVLVGYT YEDEPVFVKD LGFQGAIAAL 250
    LSTALKPNLV QTLEHTPAFV HGGPFANIAH GNNSILSTNL ALHLSDYVLS 300
    EAGFGSDLGG QKFLDFVSTK LEKKPDAAVV VATVRALKYQ AEKSTDHLKE 350
    ENLDSLKEGF ANLDRHMNNV RSYNIPVLVV INKFPTDTEA ELDLLKSLIE 400
    EQGFPCEIVT AHDEGSKGAK AAAEKIVELA DKSDYEIKRS YDLDDDLETK 450
    IEKVAKRIYH AADVEYTDKA KDQLVKLKKM GKDKLPVIIA KTQYSFTDNV 500
    KELGAPTGFT LHVKGLSLRN GAGFVVVSTG HILDMPGLPK HPAALDIDVD 550
    ETGKISGLF 559
    Length:559
    Mass (Da):60,503
    Last modified:July 10, 2007 - v2
    Checksum:i750ABAED922A5D41
    GO

    Sequence cautioni

    The sequence CAI97822.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI97822.1. Different initiation.
    RefSeqiYP_618996.2. NC_008054.1.

    Genome annotation databases

    EnsemblBacteriaiCAI97822; CAI97822; Ldb1020.
    GeneIDi4083928.
    KEGGildb:Ldb1020.
    PATRICi22217609. VBILacDel123523_0923.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI97822.1 . Different initiation.
    RefSeqi YP_618996.2. NC_008054.1.

    3D structure databases

    ProteinModelPortali Q1GA94.
    SMRi Q1GA94. Positions 5-557.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390333.Ldb1020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI97822 ; CAI97822 ; Ldb1020 .
    GeneIDi 4083928.
    KEGGi ldb:Ldb1020.
    PATRICi 22217609. VBILacDel123523_0923.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LDEL390333:GIXG-1008-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11842 / DSM 20081.

    Entry informationi

    Entry nameiFTHS_LACDA
    AccessioniPrimary (citable) accession number: Q1GA94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3