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Q1GA94

- FTHS_LACDA

UniProt

Q1GA94 - FTHS_LACDA

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Ldb1020
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLDEL390333:GIXG-1008-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Ldb1020
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Taxonomic identifieri390333 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001259: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000293039Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390333.Ldb1020.

Structurei

3D structure databases

ProteinModelPortaliQ1GA94.
SMRiQ1GA94. Positions 5-557.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1GA94-1 [UniParc]FASTAAdd to Basket

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MVKSDIEIAQ AAEELPITDV AAKLGLTSQD LEPYGYDKAK VNWQAIKRSE    50
ENGHLGKLIL VTSISPTPAG EGKSTMTIGI GDAINNQLGK KTVIALREPS 100
MGPVFGMKGG AAGGGYAQVI PMEDINLHFT GDMHALTSAI DNLSALVDNY 150
IYQGNELGLD PEKIVIKRGL DVNDRTLRKV TIGQGSKFNG VERPASFQLT 200
VGHELMAILC LSKDIADLKE RIGKVLVGYT YEDEPVFVKD LGFQGAIAAL 250
LSTALKPNLV QTLEHTPAFV HGGPFANIAH GNNSILSTNL ALHLSDYVLS 300
EAGFGSDLGG QKFLDFVSTK LEKKPDAAVV VATVRALKYQ AEKSTDHLKE 350
ENLDSLKEGF ANLDRHMNNV RSYNIPVLVV INKFPTDTEA ELDLLKSLIE 400
EQGFPCEIVT AHDEGSKGAK AAAEKIVELA DKSDYEIKRS YDLDDDLETK 450
IEKVAKRIYH AADVEYTDKA KDQLVKLKKM GKDKLPVIIA KTQYSFTDNV 500
KELGAPTGFT LHVKGLSLRN GAGFVVVSTG HILDMPGLPK HPAALDIDVD 550
ETGKISGLF 559
Length:559
Mass (Da):60,503
Last modified:July 10, 2007 - v2
Checksum:i750ABAED922A5D41
GO

Sequence cautioni

The sequence CAI97822.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI97822.1. Different initiation.
RefSeqiYP_618996.2. NC_008054.1.

Genome annotation databases

EnsemblBacteriaiCAI97822; CAI97822; Ldb1020.
GeneIDi4083928.
KEGGildb:Ldb1020.
PATRICi22217609. VBILacDel123523_0923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI97822.1 . Different initiation.
RefSeqi YP_618996.2. NC_008054.1.

3D structure databases

ProteinModelPortali Q1GA94.
SMRi Q1GA94. Positions 5-557.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390333.Ldb1020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI97822 ; CAI97822 ; Ldb1020 .
GeneIDi 4083928.
KEGGi ldb:Ldb1020.
PATRICi 22217609. VBILacDel123523_0923.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LDEL390333:GIXG-1008-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11842 / DSM 20081.

Entry informationi

Entry nameiFTHS_LACDA
AccessioniPrimary (citable) accession number: Q1GA94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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