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Q1G9Z4

- BGAL_LACDA

UniProt

Q1G9Z4 - BGAL_LACDA

Protein

Beta-galactosidase

Gene

lacZ

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei465 – 4651Proton donorBy similarity
    Active sitei532 – 5321NucleophileBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciLDEL390333:GIXG-1187-MONOMER.
    SABIO-RKQ1G9Z4.

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase (EC:3.2.1.23)
    Short name:
    Beta-gal
    Alternative name(s):
    Lactase
    Gene namesi
    Name:lacZ
    Ordered Locus Names:Ldb1201
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
    Taxonomic identifieri390333 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001259: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 10081007Beta-galactosidasePRO_0000250751Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi390333.Ldb1201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1G9Z4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000252444.
    KOiK01190.
    OMAiDPKKPYI.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1G9Z4-1 [UniParc]FASTAAdd to Basket

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    MSNKLVKEKR VDQADLAWLT DPEVYEVNTI PPHSDHESFQ SQEELEEGKS     50
    SLVQSLDGDW LIDYAENGQG PVNFYAEDFD DSNFKSVKVP GNLELQGFGQ 100
    PQYVNVQYPW DGSEEIFPPQ IPSKNPLASY VRYFDLDEAF WDKEVSLKFD 150
    GAATAIYVWL NGHFVGYGED SFTPSEFMVT KFLKKENNRL AVALYKYSSA 200
    SWLEDQDFWR MSGLFRSVTL QAKPRLHLED LKLTASLTDN YQKGKLEVEA 250
    NIAYRLPNAS FKLEVRDSEG DLVAEKLGPI RSEQLEFTLA DLPVAAWSAE 300
    KPNLYQVRLY LYQAGSLLEV SRQEVGFRNF ELKDGIMYLN GQRIVFKGAN 350
    RHEFDSKLGR AITEEDMIWD IKTMKRSNIN AVRCSHYPNQ SLFYRLCDKY 400
    GLYVIDEANL ESHGTWEKVG GHEDPSFNVP GDDQHWLGAS LSRVKNMMAR 450
    DKNHASILIW SLGNESYAGT VFAQMADYVR KADPTRVQHY EGVTHNRKFD 500
    DATQIESRMY APAKVIEEYL TNKPAKPFIS VEYAHAMGNS VGDLAAYTAL 550
    EKYPHYQGGF IWDWIDQGLE KDGHLLYGGD FDDRPTDYEF CGNGLVFADR 600
    TESPKLANVK ALYANLKLEV KDGQLFLKND NLFTNSSSYY FLTSLLVDGK 650
    LTYQSRPLTF GLEPGESGTF ALPWPEVADE KGEVVYRVTA HLKEDLPWAD 700
    EGFTVAEAEE VAQKLPEFKP EGRPDLVDSD YNLGLKGNNF QILFSKVKGW 750
    PVSLKYAGRE YLKRLPEFTF WRALTDNDRG AGYGYDLARW ENAGKYARLK 800
    DISCEVKEDS VLVKTAFTLP VALKGDLTVT YEVDGRGKIA VTADFPGAEE 850
    AGLLPAFGLN LALPKELTDY RYYGLGPNES YPDRLEGNYL GIYQGAVKKN 900
    FSPYLRPQET GNRSKVRWYQ LFDEKGGLEF TANGADLNLS ALPYSAAQIE 950
    AADHAFELTN NYTWVRALSA QMGVGGDDSW GQKVHPEFCL DAQKARQLRL 1000
    VIQPLLLK 1008
    Length:1,008
    Mass (Da):114,160
    Last modified:January 23, 2007 - v3
    Checksum:i4681BFCA448F731F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55068 Genomic DNA. Translation: AAA25244.1.
    CR954253 Genomic DNA. Translation: CAI98003.1.
    RefSeqiWP_003619632.1. NC_008054.1.
    YP_619096.1. NC_008054.1.

    Genome annotation databases

    EnsemblBacteriaiCAI98003; CAI98003; Ldb1201.
    GeneIDi4085367.
    KEGGildb:Ldb1201.
    PATRICi22217901. VBILacDel123523_1070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55068 Genomic DNA. Translation: AAA25244.1 .
    CR954253 Genomic DNA. Translation: CAI98003.1 .
    RefSeqi WP_003619632.1. NC_008054.1.
    YP_619096.1. NC_008054.1.

    3D structure databases

    ProteinModelPortali Q1G9Z4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390333.Ldb1201.

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI98003 ; CAI98003 ; Ldb1201 .
    GeneIDi 4085367.
    KEGGi ldb:Ldb1201.
    PATRICi 22217901. VBILacDel123523_1070.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000252444.
    KOi K01190.
    OMAi DPKKPYI.
    OrthoDBi EOG6XWV0T.

    Enzyme and pathway databases

    BioCyci LDEL390333:GIXG-1187-MONOMER.
    SABIO-RK Q1G9Z4.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lactose metabolism in Lactobacillus bulgaricus: analysis of the primary structure and expression of the genes involved."
      Leong-Morgenthaler P.M., Zwahlen M.-C., Hottinger H.
      J. Bacteriol. 173:1951-1957(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11842 / DSM 20081.

    Entry informationi

    Entry nameiBGAL_LACDA
    AccessioniPrimary (citable) accession number: Q1G9Z4
    Secondary accession number(s): P20043
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3