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Q1G997

- TRMB_LACDA

UniProt

Q1G997 - TRMB_LACDA

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, Ldb1525
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451S-adenosyl-L-methionine By similarity
Binding sitei70 – 701S-adenosyl-L-methionine By similarity
Binding sitei97 – 971S-adenosyl-L-methionine By similarity
Active sitei119 – 1191 By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei155 – 1551Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLDEL390333:GIXG-1505-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:Ldb1525
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Taxonomic identifieri390333 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001259: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288163Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390333.Ldb1525.

Structurei

3D structure databases

ProteinModelPortaliQ1G997.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1306Interaction with RNA Reviewed prediction
Regioni195 – 1984Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1G997-1 [UniParc]FASTAAdd to Basket

« Hide

MRLKNKPWAN ELVEEHPESA LDRPDPAEKI DWEARFGNDK PIEIEVGSGK    50
GQFITTLAKQ HPDRNFVAME IQKTAAGIIL KKKLDEGLDN LQILCADAAN 100
LVAYFGENST SKIYLNFSDP WPKSRHEKRR LTYKDFLAKY QAVLTGDGLI 150
EFKTDNSGLF AYSVKSMNNY GMHFDFMSVD LHHESEEIVE KNVETEYEHK 200
FASKGQPIYC LHAGFLAK 218
Length:218
Mass (Da):24,873
Last modified:June 27, 2006 - v1
Checksum:iA627209175A4D075
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI98325.1.
RefSeqiWP_011544085.1. NC_008054.1.
YP_619343.1. NC_008054.1.

Genome annotation databases

EnsemblBacteriaiCAI98325; CAI98325; Ldb1525.
GeneIDi4085169.
KEGGildb:Ldb1525.
PATRICi22218510. VBILacDel123523_1372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI98325.1 .
RefSeqi WP_011544085.1. NC_008054.1.
YP_619343.1. NC_008054.1.

3D structure databases

ProteinModelPortali Q1G997.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390333.Ldb1525.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI98325 ; CAI98325 ; Ldb1525 .
GeneIDi 4085169.
KEGGi ldb:Ldb1525.
PATRICi 22218510. VBILacDel123523_1372.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LDEL390333:GIXG-1505-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11842 / DSM 20081.

Entry informationi

Entry nameiTRMB_LACDA
AccessioniPrimary (citable) accession number: Q1G997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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