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Q1G864

- PYRDA_LACDA

UniProt

Q1G864 - PYRDA_LACDA

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Protein
Dihydroorotate dehydrogenase A (fumarate)
Gene
pyrD, Ldb2114
Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor By similarity.UniRule annotation

Catalytic activityi

(S)-dihydroorotate + fumarate = orotate + succinate.UniRule annotation

Cofactori

Binds 1 FMN per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei21 – 211FMN By similarity
Binding sitei46 – 461Substrate By similarity
Binding sitei130 – 1301FMN By similarity
Binding sitei130 – 1301Substrate By similarity
Active sitei133 – 1331Nucleophile
Binding sitei168 – 1681FMN By similarity
Binding sitei194 – 1941FMN; via carbonyl oxygen By similarity
Binding sitei220 – 2201FMN; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 472FMN By similarity
Nucleotide bindingi246 – 2472FMN By similarity
Nucleotide bindingi268 – 2692FMN By similarity

GO - Molecular functioni

  1. dihydroorotate oxidase activity Source: InterPro

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciLDEL390333:GIXG-2083-MONOMER.
UniPathwayiUPA00070.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase A (fumarate) (EC:1.3.98.1)
Short name:
DHOD A
Short name:
DHODase A
Short name:
DHOdehase A
Gene namesi
Name:pyrD
Ordered Locus Names:Ldb2114
OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Taxonomic identifieri390333 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001259: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Dihydroorotate dehydrogenase A (fumarate)UniRule annotation
PRO_1000024135Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi390333.Ldb2114.

Structurei

3D structure databases

ProteinModelPortaliQ1G864.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 745Substrate binding By similarity
Regioni195 – 1962Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0167.
HOGENOMiHOG000225105.
KOiK00226.
OMAiVTDIVAM.
OrthoDBiEOG6NPM9S.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00224. DHO_dh_type1.
InterProiIPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEiPS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1G864-1 [UniParc]FASTAAdd to Basket

« Hide

MVNTHVNLPG LDLKNPVMPA SGTFGFGDVP AAQKFDLNDL GAMVIKTTTP    50
HATTGNPQPQ IAILEDGVLN SVGLTNPGVD QVISEKLTKL RHQYLDLPIM 100
ASVGGDSEDD YVEVAKKLSA SGLVNALEIN VSCPNVAQGG MSFGVHAGVV 150
EELTKKIKMA VALPIYVKLT PNVTDIVEIA KAAESGGADG ISMINTVLGM 200
RIDVKTRKPL LGHNMGGLSG EAVKPIAIRM ISQVRQVTQL PIIGMGGIST 250
AQDVIEFILA GANAVAVGSA HFEDELAAKH IAENLPAELE KLGIEDINDL 300
VGQVKFN 307
Length:307
Mass (Da):32,181
Last modified:June 27, 2006 - v1
Checksum:i799B034239D6C885
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI98852.1.
RefSeqiYP_619726.1. NC_008054.1.

Genome annotation databases

EnsemblBacteriaiCAI98852; CAI98852; Ldb2114.
GeneIDi4084395.
KEGGildb:Ldb2114.
PATRICi22219615. VBILacDel123523_1862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954253 Genomic DNA. Translation: CAI98852.1 .
RefSeqi YP_619726.1. NC_008054.1.

3D structure databases

ProteinModelPortali Q1G864.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390333.Ldb2114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI98852 ; CAI98852 ; Ldb2114 .
GeneIDi 4084395.
KEGGi ldb:Ldb2114.
PATRICi 22219615. VBILacDel123523_1862.

Phylogenomic databases

eggNOGi COG0167.
HOGENOMi HOG000225105.
KOi K00226.
OMAi VTDIVAM.
OrthoDBi EOG6NPM9S.

Enzyme and pathway databases

UniPathwayi UPA00070 .
BioCyci LDEL390333:GIXG-2083-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00224. DHO_dh_type1.
InterProi IPR013785. Aldolase_TIM.
IPR005720. Dihydroorotate_DH.
IPR024920. Dihydroorotate_DH_1.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view ]
Pfami PF01180. DHO_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMsi TIGR01037. pyrD_sub1_fam. 1 hit.
PROSITEi PS00912. DHODEHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 11842 / DSM 20081.

Entry informationi

Entry nameiPYRDA_LACDA
AccessioniPrimary (citable) accession number: Q1G864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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