Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1G864

- PYRDA_LACDA

UniProt

Q1G864 - PYRDA_LACDA

Protein

Dihydroorotate dehydrogenase A (fumarate)

Gene

pyrD

Organism
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (27 Jun 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.By similarity

    Catalytic activityi

    (S)-dihydroorotate + fumarate = orotate + succinate.

    Cofactori

    Binds 1 FMN per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei21 – 211FMNBy similarity
    Binding sitei46 – 461SubstrateBy similarity
    Binding sitei130 – 1301FMNBy similarity
    Binding sitei130 – 1301SubstrateBy similarity
    Active sitei133 – 1331Nucleophile
    Binding sitei168 – 1681FMNBy similarity
    Binding sitei194 – 1941FMN; via carbonyl oxygenBy similarity
    Binding sitei220 – 2201FMN; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 472FMNBy similarity
    Nucleotide bindingi246 – 2472FMNBy similarity
    Nucleotide bindingi268 – 2692FMNBy similarity

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciLDEL390333:GIXG-2083-MONOMER.
    UniPathwayiUPA00070.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase A (fumarate) (EC:1.3.98.1)
    Short name:
    DHOD A
    Short name:
    DHODase A
    Short name:
    DHOdehase A
    Gene namesi
    Name:pyrD
    Ordered Locus Names:Ldb2114
    OrganismiLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081)
    Taxonomic identifieri390333 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001259: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Dihydroorotate dehydrogenase A (fumarate)PRO_1000024135Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi390333.Ldb2114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1G864.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 745Substrate bindingBy similarity
    Regioni195 – 1962Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0167.
    HOGENOMiHOG000225105.
    KOiK00226.
    OMAiVTDIVAM.
    OrthoDBiEOG6NPM9S.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00224. DHO_dh_type1.
    InterProiIPR013785. Aldolase_TIM.
    IPR005720. Dihydroorotate_DH.
    IPR024920. Dihydroorotate_DH_1.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01037. pyrD_sub1_fam. 1 hit.
    PROSITEiPS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1G864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNTHVNLPG LDLKNPVMPA SGTFGFGDVP AAQKFDLNDL GAMVIKTTTP    50
    HATTGNPQPQ IAILEDGVLN SVGLTNPGVD QVISEKLTKL RHQYLDLPIM 100
    ASVGGDSEDD YVEVAKKLSA SGLVNALEIN VSCPNVAQGG MSFGVHAGVV 150
    EELTKKIKMA VALPIYVKLT PNVTDIVEIA KAAESGGADG ISMINTVLGM 200
    RIDVKTRKPL LGHNMGGLSG EAVKPIAIRM ISQVRQVTQL PIIGMGGIST 250
    AQDVIEFILA GANAVAVGSA HFEDELAAKH IAENLPAELE KLGIEDINDL 300
    VGQVKFN 307
    Length:307
    Mass (Da):32,181
    Last modified:June 27, 2006 - v1
    Checksum:i799B034239D6C885
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI98852.1.
    RefSeqiYP_619726.1. NC_008054.1.

    Genome annotation databases

    EnsemblBacteriaiCAI98852; CAI98852; Ldb2114.
    GeneIDi4084395.
    KEGGildb:Ldb2114.
    PATRICi22219615. VBILacDel123523_1862.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954253 Genomic DNA. Translation: CAI98852.1 .
    RefSeqi YP_619726.1. NC_008054.1.

    3D structure databases

    ProteinModelPortali Q1G864.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390333.Ldb2114.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI98852 ; CAI98852 ; Ldb2114 .
    GeneIDi 4084395.
    KEGGi ldb:Ldb2114.
    PATRICi 22219615. VBILacDel123523_1862.

    Phylogenomic databases

    eggNOGi COG0167.
    HOGENOMi HOG000225105.
    KOi K00226.
    OMAi VTDIVAM.
    OrthoDBi EOG6NPM9S.

    Enzyme and pathway databases

    UniPathwayi UPA00070 .
    BioCyci LDEL390333:GIXG-2083-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00224. DHO_dh_type1.
    InterProi IPR013785. Aldolase_TIM.
    IPR005720. Dihydroorotate_DH.
    IPR024920. Dihydroorotate_DH_1.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01037. pyrD_sub1_fam. 1 hit.
    PROSITEi PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 11842 / DSM 20081.

    Entry informationi

    Entry nameiPYRDA_LACDA
    AccessioniPrimary (citable) accession number: Q1G864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3