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Q1G7W2 (RTPR_LACDA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:Ldb0096
OrganismLactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081) [Complete proteome] [HAMAP]
Taxonomic identifier390333 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326539

Regions

Region147 – 15812Effector region-1 By similarity
Region168 – 313146Effector region-2 By similarity
Region565 – 62662Adenosylcobalamin-binding-1 By similarity
Region685 – 72440Adenosylcobalamin-binding-2 By similarity

Sites

Active site4081 By similarity
Active site4101 By similarity

Amino acid modifications

Disulfide bond119 ↔ 419Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1G7W2 [UniParc].

Last modified June 27, 2006. Version 1.
Checksum: AA7CFEDC22FC74CF

FASTA73981,910
        10         20         30         40         50         60 
MSEGISLSAE FIDRVKASVK PHWGKLGWVT YKRTYARWLP EKGRSENWDE TVKRVVEGNI 

        70         80         90        100        110        120 
NLDPRLQDSP SLELKQSLTE EAERLYKLIY GLGATPSGRN LWISGTDYQR RTGDSLNNCW 

       130        140        150        160        170        180 
FVAIRPQKYG DSKIVPSYLG KQEKAVSMPF SFLFDELMKG GGVGFSVARS NISQIPRVDF 

       190        200        210        220        230        240 
AIDLQVVVDE SSESYDASVK VGAVGKNELV QDADSIYYRL PDTREGWVLA NALLIDLHFA 

       250        260        270        280        290        300 
QTNPDRKQKL ILDLSDIRPY GAEIHGFGGT ASGPMPLISM LLDINEVLNN KAGGRLTSVD 

       310        320        330        340        350        360 
AADICNLIGK AVVAGNVRRS AELALGSNDD QDFISMKQDQ EKLMHHRWAS NNSVAVDSAF 

       370        380        390        400        410        420 
SGYQPIAAGI RENGEPGIVN LDLSKNYGRI VDGYQAGIDG DVEGTNPCGE ISLANGEPCN 

       430        440        450        460        470        480 
LFEVFPLIAE EQGWDLQEVF ALAARYAKRV TFSPYDWEIS REIIQKNRRI GISMSGIQDW 

       490        500        510        520        530        540 
LLTRLGNRVV TGFKDDFDPE THEAIKVPVY DKRAIKMVDQ LYKAVVKADQ DYSKTLGCNE 

       550        560        570        580        590        600 
SIKHTTVKPS GTVAKLAGAS EGMHFHYGAY LIQRIRFQNS DPLLPALKAC GYRTEADIYT 

       610        620        630        640        650        660 
ENTTCVEFPV KAVGADNPNF ASAGTVSIAE QFATQAFLQT YWSDNAVSCT ITFQDSEGDQ 

       670        680        690        700        710        720 
VESLLRQYRF IIKSTSLLPY FGGSLQQAPK EPIDKETYEK RSQEITGNVE EVFSQLNSDV 

       730 
KDLELVDQTD CEGGACPIK 

« Hide

References

[1]"The complete genome sequence of Lactobacillus bulgaricus reveals extensive and ongoing reductive evolution."
van de Guchte M., Penaud S., Grimaldi C., Barbe V., Bryson K., Nicolas P., Robert C., Oztas S., Mangenot S., Couloux A., Loux V., Dervyn R., Bossy R., Bolotin A., Batto J.-M., Walunas T., Gibrat J.-F., Bessieres P. expand/collapse author list , Weissenbach J., Ehrlich S.D., Maguin E.
Proc. Natl. Acad. Sci. U.S.A. 103:9274-9279(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 11842 / DSM 20081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR954253 Genomic DNA. Translation: CAI96937.1.
RefSeqYP_618299.1. NC_008054.1.

3D structure databases

ProteinModelPortalQ1G7W2.
SMRQ1G7W2. Positions 5-724.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390333.Ldb0096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI96937; CAI96937; Ldb0096.
GeneID4084028.
KEGGldb:Ldb0096.
PATRIC22215846. VBILacDel123523_0082.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
HOGENOMHOG000068540.
KOK00527.
OMADSLNNCW.
OrthoDBEOG68DCVH.

Enzyme and pathway databases

BioCycLDEL390333:GIXG-94-MONOMER.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACDA
AccessionPrimary (citable) accession number: Q1G7W2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families