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Protein

Sodium-coupled monocarboxylate transporter 2

Gene

SLC5A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (By similarity).By similarity1 Publication

Enzyme regulationi

Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.21.5.6. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled monocarboxylate transporter 2
Alternative name(s):
Electroneutral sodium monocarboxylate cotransporter
Low-affinity sodium-lactate cotransporter
Solute carrier family 5 member 12
Gene namesi
Name:SLC5A12
Synonyms:SMCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28750. SLC5A12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence analysis
Transmembranei10 – 3021HelicalSequence analysisAdd
BLAST
Topological domaini31 – 4717CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 8214ExtracellularSequence analysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence analysisAdd
BLAST
Topological domaini104 – 12825CytoplasmicSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Topological domaini150 – 1578ExtracellularSequence analysis
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 1802CytoplasmicSequence analysis
Transmembranei181 – 20121HelicalSequence analysisAdd
BLAST
Topological domaini202 – 23534ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 27519CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Topological domaini297 – 32125ExtracellularSequence analysisAdd
BLAST
Transmembranei322 – 34221HelicalSequence analysisAdd
BLAST
Topological domaini343 – 38543CytoplasmicSequence analysisAdd
BLAST
Transmembranei386 – 40621HelicalSequence analysisAdd
BLAST
Topological domaini407 – 4115ExtracellularSequence analysis
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Topological domaini433 – 4375CytoplasmicSequence analysis
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Topological domaini459 – 50446ExtracellularSequence analysisAdd
BLAST
Transmembranei505 – 52521HelicalSequence analysisAdd
BLAST
Topological domaini526 – 61893CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873929.

Polymorphism and mutation databases

BioMutaiSLC5A12.
DMDMi189046187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Sodium-coupled monocarboxylate transporter 2PRO_0000337680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1EHB4.
PeptideAtlasiQ1EHB4.
PRIDEiQ1EHB4.

PTM databases

iPTMnetiQ1EHB4.
PhosphoSiteiQ1EHB4.

Expressioni

Gene expression databases

BgeeiENSG00000148942.
CleanExiHS_SLC5A12.
ExpressionAtlasiQ1EHB4. baseline and differential.
GenevisibleiQ1EHB4. HS.

Organism-specific databases

HPAiHPA060904.

Interactioni

Protein-protein interaction databases

BioGridi127745. 1 interaction.
MINTiMINT-4723095.
STRINGi9606.ENSP00000379326.

Structurei

3D structure databases

ProteinModelPortaliQ1EHB4.
SMRiQ1EHB4. Positions 53-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ1EHB4.
KOiK14388.
OMAiAIADTWY.
OrthoDBiEOG091G07OC.
PhylomeDBiQ1EHB4.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1EHB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKNFAVWD YVVFAALFFI SSGIGVFFAI KERKKATSRE FLVGGRQMSF
60 70 80 90 100
GPVGLSLTAS FMSAVTVLGT PSEVYRFGAS FLVFFIAYLF VILLTSELFL
110 120 130 140 150
PVFYRSGITS TYEYLQLRFN KPVRYAATVI YIVQTILYTG VVVYAPALAL
160 170 180 190 200
NQVTGFDLWG SVFATGIVCT FYCTLGGLKA VVWTDAFQMV VMIVGFLTVL
210 220 230 240 250
IQGSTHAGGF HNVLEQSTNG SRLHIFDFDV DPLRRHTFWT ITVGGTFTWL
260 270 280 290 300
GIYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIILVCA VFSGLIMYSH
310 320 330 340 350
FKDCDPWTSG IISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA
360 370 380 390 400
SSINALATVT FEDFVKSCFP HLSDKLSTWI SKGLCLLFGV MCTSMAVAAS
410 420 430 440 450
VMGGVVQASL SIHGMCGGPM LGLFSLGIVF PFVNWKGALG GLLTGITLSF
460 470 480 490 500
WVAIGAFIYP APASKTWPLP LSTDQCIKSN VTATGPPVLS SRPGIADTWY
510 520 530 540 550
SISYLYYSAV GCLGCIVAGV IISLITGRQR GEDIQPLLIR PVCNLFCFWS
560 570 580 590 600
KKYKTLCWCG VQHDSGTEQE NLENGSARKQ GAESVLQNGL RRESLVHVPG
610
YDPKDKSYNN MAFETTHF
Length:618
Mass (Da):67,647
Last modified:May 20, 2008 - v2
Checksum:i01D5F954BD28EF6F
GO
Isoform 2 (identifier: Q1EHB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-396: LLFGVMCTSMA → RYSWWTFYSIS
     397-618: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,077
Checksum:i84BAB86B6E9A9F4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851I → V in AAQ73572 (Ref. 2) Curated
Sequence conflicti396 – 3961A → S in AAQ73572 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti510 – 5101V → L.
Corresponds to variant rs12278761 [ dbSNP | Ensembl ].
VAR_043703

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei386 – 39611LLFGVMCTSMA → RYSWWTFYSIS in isoform 2. 1 PublicationVSP_033994Add
BLAST
Alternative sequencei397 – 618222Missing in isoform 2. 1 PublicationVSP_033995Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299482 mRNA. Translation: AAQ73572.1.
AC083755 Genomic DNA. No translation available.
BC049207 mRNA. Translation: AAH49207.1.
CCDSiCCDS7860.2. [Q1EHB4-1]
RefSeqiNP_848593.2. NM_178498.3. [Q1EHB4-1]
UniGeneiHs.148907.

Genome annotation databases

EnsembliENST00000280467; ENSP00000280467; ENSG00000148942. [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942. [Q1EHB4-1]
GeneIDi159963.
KEGGihsa:159963.
UCSCiuc001mra.3. human. [Q1EHB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299482 mRNA. Translation: AAQ73572.1.
AC083755 Genomic DNA. No translation available.
BC049207 mRNA. Translation: AAH49207.1.
CCDSiCCDS7860.2. [Q1EHB4-1]
RefSeqiNP_848593.2. NM_178498.3. [Q1EHB4-1]
UniGeneiHs.148907.

3D structure databases

ProteinModelPortaliQ1EHB4.
SMRiQ1EHB4. Positions 53-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127745. 1 interaction.
MINTiMINT-4723095.
STRINGi9606.ENSP00000379326.

Protein family/group databases

TCDBi2.A.21.5.6. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiQ1EHB4.
PhosphoSiteiQ1EHB4.

Polymorphism and mutation databases

BioMutaiSLC5A12.
DMDMi189046187.

Proteomic databases

PaxDbiQ1EHB4.
PeptideAtlasiQ1EHB4.
PRIDEiQ1EHB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280467; ENSP00000280467; ENSG00000148942. [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942. [Q1EHB4-1]
GeneIDi159963.
KEGGihsa:159963.
UCSCiuc001mra.3. human. [Q1EHB4-1]

Organism-specific databases

CTDi159963.
GeneCardsiSLC5A12.
H-InvDBHIX0026178.
HGNCiHGNC:28750. SLC5A12.
HPAiHPA060904.
MIMi612455. gene.
neXtProtiNX_Q1EHB4.
PharmGKBiPA134873929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ1EHB4.
KOiK14388.
OMAiAIADTWY.
OrthoDBiEOG091G07OC.
PhylomeDBiQ1EHB4.
TreeFamiTF316728.

Miscellaneous databases

GenomeRNAii159963.
PROiQ1EHB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148942.
CleanExiHS_SLC5A12.
ExpressionAtlasiQ1EHB4. baseline and differential.
GenevisibleiQ1EHB4. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5AC_HUMAN
AccessioniPrimary (citable) accession number: Q1EHB4
Secondary accession number(s): Q86UC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.