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Protein

Sodium-coupled monocarboxylate transporter 2

Gene

SLC5A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (By similarity).By similarity1 Publication

Enzyme regulationi

Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148942-MONOMER.
ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.21.5.6. the solute:sodium symporter (sss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled monocarboxylate transporter 2
Alternative name(s):
Electroneutral sodium monocarboxylate cotransporter
Low-affinity sodium-lactate cotransporter
Solute carrier family 5 member 12
Gene namesi
Name:SLC5A12
Synonyms:SMCT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28750. SLC5A12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 47CytoplasmicSequence analysisAdd BLAST17
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 82ExtracellularSequence analysisAdd BLAST14
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 128CytoplasmicSequence analysisAdd BLAST25
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 157ExtracellularSequence analysis8
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 180CytoplasmicSequence analysis2
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 235ExtracellularSequence analysisAdd BLAST34
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 275CytoplasmicSequence analysisAdd BLAST19
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 321ExtracellularSequence analysisAdd BLAST25
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 385CytoplasmicSequence analysisAdd BLAST43
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 411ExtracellularSequence analysis5
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 437CytoplasmicSequence analysis5
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 504ExtracellularSequence analysisAdd BLAST46
Transmembranei505 – 525HelicalSequence analysisAdd BLAST21
Topological domaini526 – 618CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi159963.
OpenTargetsiENSG00000148942.
PharmGKBiPA134873929.

Polymorphism and mutation databases

BioMutaiSLC5A12.
DMDMi189046187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003376801 – 618Sodium-coupled monocarboxylate transporter 2Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1EHB4.
PeptideAtlasiQ1EHB4.
PRIDEiQ1EHB4.

PTM databases

iPTMnetiQ1EHB4.
PhosphoSitePlusiQ1EHB4.

Expressioni

Gene expression databases

BgeeiENSG00000148942.
CleanExiHS_SLC5A12.
ExpressionAtlasiQ1EHB4. baseline and differential.
GenevisibleiQ1EHB4. HS.

Organism-specific databases

HPAiHPA060904.

Interactioni

Protein-protein interaction databases

BioGridi127745. 1 interactor.
MINTiMINT-4723095.
STRINGi9606.ENSP00000379326.

Structurei

3D structure databases

ProteinModelPortaliQ1EHB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ1EHB4.
KOiK14388.
OMAiAIADTWY.
OrthoDBiEOG091G07OC.
PhylomeDBiQ1EHB4.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1EHB4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVKNFAVWD YVVFAALFFI SSGIGVFFAI KERKKATSRE FLVGGRQMSF
60 70 80 90 100
GPVGLSLTAS FMSAVTVLGT PSEVYRFGAS FLVFFIAYLF VILLTSELFL
110 120 130 140 150
PVFYRSGITS TYEYLQLRFN KPVRYAATVI YIVQTILYTG VVVYAPALAL
160 170 180 190 200
NQVTGFDLWG SVFATGIVCT FYCTLGGLKA VVWTDAFQMV VMIVGFLTVL
210 220 230 240 250
IQGSTHAGGF HNVLEQSTNG SRLHIFDFDV DPLRRHTFWT ITVGGTFTWL
260 270 280 290 300
GIYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIILVCA VFSGLIMYSH
310 320 330 340 350
FKDCDPWTSG IISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA
360 370 380 390 400
SSINALATVT FEDFVKSCFP HLSDKLSTWI SKGLCLLFGV MCTSMAVAAS
410 420 430 440 450
VMGGVVQASL SIHGMCGGPM LGLFSLGIVF PFVNWKGALG GLLTGITLSF
460 470 480 490 500
WVAIGAFIYP APASKTWPLP LSTDQCIKSN VTATGPPVLS SRPGIADTWY
510 520 530 540 550
SISYLYYSAV GCLGCIVAGV IISLITGRQR GEDIQPLLIR PVCNLFCFWS
560 570 580 590 600
KKYKTLCWCG VQHDSGTEQE NLENGSARKQ GAESVLQNGL RRESLVHVPG
610
YDPKDKSYNN MAFETTHF
Length:618
Mass (Da):67,647
Last modified:May 20, 2008 - v2
Checksum:i01D5F954BD28EF6F
GO
Isoform 2 (identifier: Q1EHB4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-396: LLFGVMCTSMA → RYSWWTFYSIS
     397-618: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,077
Checksum:i84BAB86B6E9A9F4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti285I → V in AAQ73572 (Ref. 2) Curated1
Sequence conflicti396A → S in AAQ73572 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043703510V → L.Corresponds to variant rs12278761dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033994386 – 396LLFGVMCTSMA → RYSWWTFYSIS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_033995397 – 618Missing in isoform 2. 1 PublicationAdd BLAST222

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299482 mRNA. Translation: AAQ73572.1.
AC083755 Genomic DNA. No translation available.
BC049207 mRNA. Translation: AAH49207.1.
CCDSiCCDS7860.2. [Q1EHB4-1]
RefSeqiNP_848593.2. NM_178498.3. [Q1EHB4-1]
UniGeneiHs.148907.

Genome annotation databases

EnsembliENST00000280467; ENSP00000280467; ENSG00000148942. [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942. [Q1EHB4-1]
GeneIDi159963.
KEGGihsa:159963.
UCSCiuc001mra.3. human. [Q1EHB4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299482 mRNA. Translation: AAQ73572.1.
AC083755 Genomic DNA. No translation available.
BC049207 mRNA. Translation: AAH49207.1.
CCDSiCCDS7860.2. [Q1EHB4-1]
RefSeqiNP_848593.2. NM_178498.3. [Q1EHB4-1]
UniGeneiHs.148907.

3D structure databases

ProteinModelPortaliQ1EHB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127745. 1 interactor.
MINTiMINT-4723095.
STRINGi9606.ENSP00000379326.

Protein family/group databases

TCDBi2.A.21.5.6. the solute:sodium symporter (sss) family.

PTM databases

iPTMnetiQ1EHB4.
PhosphoSitePlusiQ1EHB4.

Polymorphism and mutation databases

BioMutaiSLC5A12.
DMDMi189046187.

Proteomic databases

PaxDbiQ1EHB4.
PeptideAtlasiQ1EHB4.
PRIDEiQ1EHB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280467; ENSP00000280467; ENSG00000148942. [Q1EHB4-2]
ENST00000396005; ENSP00000379326; ENSG00000148942. [Q1EHB4-1]
GeneIDi159963.
KEGGihsa:159963.
UCSCiuc001mra.3. human. [Q1EHB4-1]

Organism-specific databases

CTDi159963.
DisGeNETi159963.
GeneCardsiSLC5A12.
H-InvDBHIX0026178.
HGNCiHGNC:28750. SLC5A12.
HPAiHPA060904.
MIMi612455. gene.
neXtProtiNX_Q1EHB4.
OpenTargetsiENSG00000148942.
PharmGKBiPA134873929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ1EHB4.
KOiK14388.
OMAiAIADTWY.
OrthoDBiEOG091G07OC.
PhylomeDBiQ1EHB4.
TreeFamiTF316728.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148942-MONOMER.
ReactomeiR-HSA-427601. Multifunctional anion exchangers.

Miscellaneous databases

GenomeRNAii159963.
PROiQ1EHB4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148942.
CleanExiHS_SLC5A12.
ExpressionAtlasiQ1EHB4. baseline and differential.
GenevisibleiQ1EHB4. HS.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5AC_HUMAN
AccessioniPrimary (citable) accession number: Q1EHB4
Secondary accession number(s): Q86UC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.