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Q1EG59

- Q1EG59_RHIAP

UniProt

Q1EG59 - Q1EG59_RHIAP

Protein
Submitted name:

Tryptase inhibitor

Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561Sulfate 1Imported
    Binding sitei79 – 791Sulfate 1; via amide nitrogenImported
    Binding sitei86 – 861Sulfate 2Imported
    Binding sitei92 – 921Sulfate 2Imported

    Protein family/group databases

    MEROPSiI02.053.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tryptase inhibitorImported
    OrganismiRhipicephalus appendiculatus (Brown ear tick)Imported
    Taxonomic identifieri34631 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121 PotentialImportedAdd
    BLAST
    Chaini22 – 11897tryptase inhibitorImportedPRO_5000094004Add
    BLAST

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LFKNMR-A42-96[»]
    2LFLNMR-A42-96[»]
    2UUXX-ray1.40A44-96[»]
    2UUYX-ray1.15B45-95[»]
    ProteinModelPortaliQ1EG59.
    SMRiQ1EG59. Positions 44-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ1EG59.

    Family & Domainsi

    Keywords - Domaini

    SignalImported

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1EG59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRTTLIVAI VLVAFVASTL GNAYPKVEER RNRPNWDFGK RKEECTVPIG    50
    WSEPVKGLCK ARFTRYYCMG NCCKVYEGCY TGGYSRMGEC ARNCPGFKRP 100
    TPGFRPRHGL ENGTEPGP 118
    Length:118
    Mass (Da):13,216
    Last modified:July 11, 2006 - v1
    Checksum:iA1B78F15E3BFFE25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY710292 mRNA. Translation: AAW32666.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY710292 mRNA. Translation: AAW32666.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LFK NMR - A 42-96 [» ]
    2LFL NMR - A 42-96 [» ]
    2UUX X-ray 1.40 A 44-96 [» ]
    2UUY X-ray 1.15 B 45-95 [» ]
    ProteinModelPortali Q1EG59.
    SMRi Q1EG59. Positions 44-96.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I02.053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q1EG59.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A tick protein with a modified Kunitz fold inhibits human tryptase."
      Paesen G.C., Siebold C., Harlos K., Peacey M.F., Nuttall P.A., Stuart D.I.
      J. Mol. Biol. 368:1172-1186(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Salivary glandsImported.
    2. "Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications."
      Bronsoms S., Pantoja-Uceda D., Gabrijelcic-Geiger D., Sanglas L., Aviles F.X., Santoro J., Sommerhoff C.P., Arolas J.L.
      J. Mol. Biol. 414:427-441(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 42-96.

    Entry informationi

    Entry nameiQ1EG59_RHIAP
    AccessioniPrimary (citable) accession number: Q1EG59
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3