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Protein
Submitted name:

Tryptase inhibitor

Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

MEROPSiI02.053.

Names & Taxonomyi

Protein namesi
Submitted name:
Tryptase inhibitorImported
OrganismiRhipicephalus appendiculatus (Brown ear tick)Imported
Taxonomic identifieri34631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 PotentialImportedAdd
BLAST
Chaini22 – 11897tryptase inhibitorImportedPRO_5000094004Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LFKNMR-A42-96[»]
2LFLNMR-A42-96[»]
2UUXX-ray1.40A44-96[»]
2UUYX-ray1.15B45-95[»]
ProteinModelPortaliQ1EG59.
SMRiQ1EG59. Positions 44-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ1EG59.

Family & Domainsi

Keywords - Domaini

SignalImported

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1EG59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRTTLIVAI VLVAFVASTL GNAYPKVEER RNRPNWDFGK RKEECTVPIG
60 70 80 90 100
WSEPVKGLCK ARFTRYYCMG NCCKVYEGCY TGGYSRMGEC ARNCPGFKRP
110
TPGFRPRHGL ENGTEPGP
Length:118
Mass (Da):13,216
Last modified:July 11, 2006 - v1
Checksum:iA1B78F15E3BFFE25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY710292 mRNA. Translation: AAW32666.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY710292 mRNA. Translation: AAW32666.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LFKNMR-A42-96[»]
2LFLNMR-A42-96[»]
2UUXX-ray1.40A44-96[»]
2UUYX-ray1.15B45-95[»]
ProteinModelPortaliQ1EG59.
SMRiQ1EG59. Positions 44-96.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI02.053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ1EG59.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "A tick protein with a modified Kunitz fold inhibits human tryptase."
    Paesen G.C., Siebold C., Harlos K., Peacey M.F., Nuttall P.A., Stuart D.I.
    J. Mol. Biol. 368:1172-1186(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Salivary glandsImported.
  2. "Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications."
    Bronsoms S., Pantoja-Uceda D., Gabrijelcic-Geiger D., Sanglas L., Aviles F.X., Santoro J., Sommerhoff C.P., Arolas J.L.
    J. Mol. Biol. 414:427-441(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 42-96, ACTIVE SITE.

Entry informationi

Entry nameiQ1EG59_RHIAP
AccessioniPrimary (citable) accession number: Q1EG59
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: January 7, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.