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Q1EG59

- Q1EG59_RHIAP

UniProt

Q1EG59 - Q1EG59_RHIAP

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Protein
Submitted name: Tryptase inhibitor
Gene
N/A
Organism
Rhipicephalus appendiculatus (Brown ear tick)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Sulfate 1Imported
Binding sitei79 – 791Sulfate 1; via amide nitrogenImported
Binding sitei86 – 861Sulfate 2Imported
Binding sitei92 – 921Sulfate 2Imported

Protein family/group databases

MEROPSiI02.053.

Names & Taxonomyi

Protein namesi
Submitted name:
Tryptase inhibitorImported
OrganismiRhipicephalus appendiculatus (Brown ear tick)Imported
Taxonomic identifieri34631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 PredictedImported
Add
BLAST
Chaini22 – 11897tryptase inhibitorImported
PRO_5000094004Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LFKNMR-A42-96[»]
2LFLNMR-A42-96[»]
2UUXX-ray1.40A44-96[»]
2UUYX-ray1.15B45-95[»]
ProteinModelPortaliQ1EG59.
SMRiQ1EG59. Positions 44-96.

Miscellaneous databases

EvolutionaryTraceiQ1EG59.

Family & Domainsi

Keywords - Domaini

SignalImported

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1EG59-1 [UniParc]FASTAAdd to Basket

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MGRTTLIVAI VLVAFVASTL GNAYPKVEER RNRPNWDFGK RKEECTVPIG    50
WSEPVKGLCK ARFTRYYCMG NCCKVYEGCY TGGYSRMGEC ARNCPGFKRP 100
TPGFRPRHGL ENGTEPGP 118
Length:118
Mass (Da):13,216
Last modified:July 11, 2006 - v1
Checksum:iA1B78F15E3BFFE25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY710292 mRNA. Translation: AAW32666.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY710292 mRNA. Translation: AAW32666.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LFK NMR - A 42-96 [» ]
2LFL NMR - A 42-96 [» ]
2UUX X-ray 1.40 A 44-96 [» ]
2UUY X-ray 1.15 B 45-95 [» ]
ProteinModelPortali Q1EG59.
SMRi Q1EG59. Positions 44-96.
ModBasei Search...

Protein family/group databases

MEROPSi I02.053.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q1EG59.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "A tick protein with a modified Kunitz fold inhibits human tryptase."
    Paesen G.C., Siebold C., Harlos K., Peacey M.F., Nuttall P.A., Stuart D.I.
    J. Mol. Biol. 368:1172-1186(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Salivary glandsImported.
  2. "Oxidative folding and structural analyses of a Kunitz-related inhibitor and its disulfide intermediates: functional implications."
    Bronsoms S., Pantoja-Uceda D., Gabrijelcic-Geiger D., Sanglas L., Aviles F.X., Santoro J., Sommerhoff C.P., Arolas J.L.
    J. Mol. Biol. 414:427-441(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 42-96.

Entry informationi

Entry nameiQ1EG59_RHIAP
AccessioniPrimary (citable) accession number: Q1EG59
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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