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Protein

Lysine-rich nucleolar protein 1

Gene

KNOP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-rich nucleolar protein 1
Alternative name(s):
Protein FAM191A
Testis-specific gene 118 protein
Gene namesi
Name:KNOP1
Synonyms:C16orf88, FAM191A, TSG118
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103550.13
HGNCiHGNC:34404 KNOP1
neXtProtiNX_Q1ED39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103550
PharmGKBiPA162378471

Polymorphism and mutation databases

BioMutaiKNOP1
DMDMi121940661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219381 – 458Lysine-rich nucleolar protein 1Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei42PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Cross-linki101Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei111PhosphoserineCombined sources1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei132PhosphoserineCombined sources1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei265PhosphoserineCombined sources1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei308PhosphothreonineCombined sources1
Modified residuei310PhosphothreonineCombined sources1
Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki373Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki407Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei430Omega-N-methylarginineCombined sources1
Cross-linki442Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ1ED39
MaxQBiQ1ED39
PaxDbiQ1ED39
PeptideAtlasiQ1ED39
PRIDEiQ1ED39
ProteomicsDBi61208

PTM databases

iPTMnetiQ1ED39
PhosphoSitePlusiQ1ED39

Expressioni

Gene expression databases

BgeeiENSG00000103550
CleanExiHS_C16orf88
ExpressionAtlasiQ1ED39 baseline and differential
GenevisibleiQ1ED39 HS

Organism-specific databases

HPAiHPA041079
HPA066169

Interactioni

Subunit structurei

Interacts with ZNF106.By similarity

Protein-protein interaction databases

BioGridi134613, 81 interactors
IntActiQ1ED39, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliQ1ED39
SMRiQ1ED39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni306 – 458Interaction with ZNF106By similarityAdd BLAST153

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Lys6
Compositional biasi65 – 295Lys-richAdd BLAST231

Phylogenomic databases

eggNOGiENOG410IVRA Eukaryota
ENOG41120AA LUCA
GeneTreeiENSGT00500000044955
HOGENOMiHOG000111906
HOVERGENiHBG107751
InParanoidiQ1ED39
OMAiKKKIHQE
OrthoDBiEOG091G0D6E
PhylomeDBiQ1ED39
TreeFamiTF336149

Family and domain databases

InterProiView protein in InterPro
IPR028124 SMAP_dom
PfamiView protein in Pfam
PF15477 SMAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q1ED39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITKTHKVDL GLPEKKKKKK VVKEPETRYS VLNNDDYFAD VSPLRATSPS
60 70 80 90 100
KSVAHGQAPE MPLVKKKKKK KKGVSTLCEE HVEPETTLPA RRTEKSPSLR
110 120 130 140 150
KQVFGHLEFL SGEKKNKKSP LAMSHASGVK TSPDPRQGEE ETRVGKKLKK
160 170 180 190 200
HKKEKKGAQD PTAFSVQDPW FCEAREARDV GDTCSVGKKD EEQAALGQKR
210 220 230 240 250
KRKSPREHNG KVKKKKKIHQ EGDALPGHSK PSRSMESSPR KGSKKKPVKV
260 270 280 290 300
EAPEYIPISD DPKASAKKKM KSKKKVEQPV IEEPALKRKK KKKRKESGVA
310 320 330 340 350
GDPWKEETDT DLEVVLEKKG NMDEAHIDQV RRKALQEEID RESGKTEASE
360 370 380 390 400
TRKWTGTQFG QWDTAGFENE DQKLKFLRLM GGFKNLSPSF SRPASTIARP
410 420 430 440 450
NMALGKKAAD SLQQNLQRDY DRAMSWKYSR GAGLGFSTAP NKIFYIDRNA

SKSVKLED
Length:458
Mass (Da):51,589
Last modified:July 11, 2006 - v1
Checksum:iF3935374029D61D9
GO

Sequence cautioni

The sequence AAC05805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH89430 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06171628R → Q. Corresponds to variant dbSNP:rs11640454Ensembl.1
Natural variantiVAR_039387266A → V. Corresponds to variant dbSNP:rs2074036Ensembl.1
Natural variantiVAR_061717276V → A. Corresponds to variant dbSNP:rs28424569Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002550 Genomic DNA Translation: AAC05805.1 Different initiation.
BC089430 mRNA Translation: AAH89430.1 Sequence problems.
BC117562 mRNA Translation: AAI17563.1
CCDSiCCDS42127.1
RefSeqiNP_001013009.2, NM_001012991.2
NP_001335457.1, NM_001348528.1
NP_001335458.1, NM_001348529.1
NP_001335459.1, NM_001348530.1
NP_001335460.1, NM_001348531.1
UniGeneiHs.585209

Genome annotation databases

EnsembliENST00000219837; ENSP00000219837; ENSG00000103550
GeneIDi400506
KEGGihsa:400506
UCSCiuc002dgq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKNOP1_HUMAN
AccessioniPrimary (citable) accession number: Q1ED39
Secondary accession number(s): O43328, Q5FWF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 11, 2006
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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