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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109ATPPROSITE-ProRule annotation1
Active sitei211Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 93ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:CIMG_00063
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_00063.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129411 – 467Serine/threonine-protein kinase SSN3Add BLAST467

Proteomic databases

PRIDEiQ1EBK0.

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1EBK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 408Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ1EBK0.
KOiK02208.
OrthoDBiEOG093707SR.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1EBK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSNLPPSS GRGSHADGAS GRSMPPFPGS SSFTANNPSK GIHPNLTLKR
60 70 80 90 100
SVQSFDESLD NKKPLPFSYA SKVKLREKYL IVGFISSGTY GRVYKAKGRD
110 120 130 140 150
GVGGDFAIKK FKPDKEGEKV EYTGLSQSAI REISLCTELN HPNVVRLVET
160 170 180 190 200
ILEDKCVYMV FEYTEHDLLQ IIHHHTQPQR HAIPAPMVKS ILFQLLNGLL
210 220 230 240 250
YLHSQWVMHR DLKPANILVT SKGAVRIGDL GLARVFKKPL NSLFSGDKVV
260 270 280 290 300
VTIWYRAPEL LLGARHYTTA VDLWAVGCIF AELLSLRPIF KGEEAKMDSK
310 320 330 340 350
KTVPFQRNQM LKIIEILGLP KKEKWPGLSS MPEFPQLQAM AMAPGSGHLH
360 370 380 390 400
KPSNLEHWYH VCLKSGGYSG SSPAGSPGKE GFDLLSRLLE YDPEKRISAK
410 420 430 440 450
EALNHPYFTT GTPVAKNCFE GFEGKYPNRR VSQDDNDIRS GSLPGTKRSG
460
LPDDTLTSRA AKRAREM
Length:467
Mass (Da):51,863
Last modified:January 9, 2013 - v3
Checksum:i80730421A67B6106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS34709.3.
RefSeqiXP_001246292.2. XM_001246291.2.

Genome annotation databases

EnsemblFungiiEAS34709; EAS34709; CIMG_00063.
GeneIDi4566191.
KEGGicim:CIMG_00063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS34709.3.
RefSeqiXP_001246292.2. XM_001246291.2.

3D structure databases

ProteinModelPortaliQ1EBK0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1EBK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAS34709; EAS34709; CIMG_00063.
GeneIDi4566191.
KEGGicim:CIMG_00063.

Organism-specific databases

EuPathDBiFungiDB:CIMG_00063.

Phylogenomic databases

InParanoidiQ1EBK0.
KOiK02208.
OrthoDBiEOG093707SR.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSN3_COCIM
AccessioniPrimary (citable) accession number: Q1EBK0
Secondary accession number(s): J3KG40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2013
Last modified: February 15, 2017
This is version 75 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.