Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109ATPPROSITE-ProRule annotation1
Active sitei211Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 93ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
ORF Names:CIMG_00063
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_00063

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129411 – 467Serine/threonine-protein kinase SSN3Add BLAST467

Proteomic databases

PRIDEiQ1EBK0

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1EBK0
SMRiQ1EBK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 408Protein kinasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ1EBK0
KOiK02208
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q1EBK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSNLPPSS GRGSHADGAS GRSMPPFPGS SSFTANNPSK GIHPNLTLKR
60 70 80 90 100
SVQSFDESLD NKKPLPFSYA SKVKLREKYL IVGFISSGTY GRVYKAKGRD
110 120 130 140 150
GVGGDFAIKK FKPDKEGEKV EYTGLSQSAI REISLCTELN HPNVVRLVET
160 170 180 190 200
ILEDKCVYMV FEYTEHDLLQ IIHHHTQPQR HAIPAPMVKS ILFQLLNGLL
210 220 230 240 250
YLHSQWVMHR DLKPANILVT SKGAVRIGDL GLARVFKKPL NSLFSGDKVV
260 270 280 290 300
VTIWYRAPEL LLGARHYTTA VDLWAVGCIF AELLSLRPIF KGEEAKMDSK
310 320 330 340 350
KTVPFQRNQM LKIIEILGLP KKEKWPGLSS MPEFPQLQAM AMAPGSGHLH
360 370 380 390 400
KPSNLEHWYH VCLKSGGYSG SSPAGSPGKE GFDLLSRLLE YDPEKRISAK
410 420 430 440 450
EALNHPYFTT GTPVAKNCFE GFEGKYPNRR VSQDDNDIRS GSLPGTKRSG
460
LPDDTLTSRA AKRAREM
Length:467
Mass (Da):51,863
Last modified:January 9, 2013 - v3
Checksum:i80730421A67B6106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA Translation: EAS34709.3
RefSeqiXP_001246292.2, XM_001246291.2

Genome annotation databases

EnsemblFungiiEAS34709; EAS34709; CIMG_00063
GeneIDi4566191
KEGGicim:CIMG_00063

Similar proteinsi

Entry informationi

Entry nameiSSN3_COCIM
AccessioniPrimary (citable) accession number: Q1EBK0
Secondary accession number(s): J3KG40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2013
Last modified: March 28, 2018
This is version 78 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health