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Q1EBK0 (SSN3_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
ORF Names:CIMG_00063
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Serine/threonine-protein kinase SSN3
PRO_0000312941

Regions

Domain79 – 408330Protein kinase
Nucleotide binding85 – 939ATP By similarity

Sites

Active site2111Proton acceptor By similarity
Binding site1091ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1EBK0 [UniParc].

Last modified January 9, 2013. Version 3.
Checksum: 80730421A67B6106

FASTA46751,863
        10         20         30         40         50         60 
MSFSNLPPSS GRGSHADGAS GRSMPPFPGS SSFTANNPSK GIHPNLTLKR SVQSFDESLD 

        70         80         90        100        110        120 
NKKPLPFSYA SKVKLREKYL IVGFISSGTY GRVYKAKGRD GVGGDFAIKK FKPDKEGEKV 

       130        140        150        160        170        180 
EYTGLSQSAI REISLCTELN HPNVVRLVET ILEDKCVYMV FEYTEHDLLQ IIHHHTQPQR 

       190        200        210        220        230        240 
HAIPAPMVKS ILFQLLNGLL YLHSQWVMHR DLKPANILVT SKGAVRIGDL GLARVFKKPL 

       250        260        270        280        290        300 
NSLFSGDKVV VTIWYRAPEL LLGARHYTTA VDLWAVGCIF AELLSLRPIF KGEEAKMDSK 

       310        320        330        340        350        360 
KTVPFQRNQM LKIIEILGLP KKEKWPGLSS MPEFPQLQAM AMAPGSGHLH KPSNLEHWYH 

       370        380        390        400        410        420 
VCLKSGGYSG SSPAGSPGKE GFDLLSRLLE YDPEKRISAK EALNHPYFTT GTPVAKNCFE 

       430        440        450        460 
GFEGKYPNRR VSQDDNDIRS GSLPGTKRSG LPDDTLTSRA AKRAREM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704911 Genomic DNA. Translation: EAS34670.2.
RefSeqXP_001246253.1. XM_001246252.1.

3D structure databases

ProteinModelPortalQ1EBK0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4567622.
KEGGcim:CIMG_00024.

Phylogenomic databases

OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_COCIM
AccessionPrimary (citable) accession number: Q1EBK0
Secondary accession number(s): J3KG40
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families