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Protein

Endochitinase 2

Gene

CTS2

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be associated with endosporulation.

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase 2 (EC:3.2.1.14)
Gene namesi
Name:CTS2
ORF Names:CIMG_00348
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_00348.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025228723 – 866Endochitinase 2Add BLAST844
PropeptideiPRO_0000252288867 – 895Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi866GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi246410.XP_001246577.1.

Structurei

3D structure databases

ProteinModelPortaliQ1EAR5.
SMRiQ1EAR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 840Ser/Thr-richAdd BLAST495

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4701. Eukaryota.
ENOG4111GPA. LUCA.
InParanoidiQ1EAR5.
KOiK01183.
OrthoDBiEOG092C4MM9.

Family and domain databases

InterProiView protein in InterPro
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00704. Glyco_hydro_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1EAR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTNILAAF IAVSSLFIQS LALNPYAKSN LAVYWGQGAG QNRLSYFCEK
60 70 80 90 100
TSFDIIVVGF INVFPDQGPA GWPGSNFGNQ CADSYYYTKN GTKTKLLDGC
110 120 130 140 150
YQIKEDLPKC KALGKTILLS LGGGAVHDFY EVKSEESALN FADFLWGAFG
160 170 180 190 200
PLTPDWTGPR PFGEASVDGF DFDIEKGSNF GYSIMVRRLR ELFLQDPLNR
210 220 230 240 250
YYISAAPQCI MPDKYLSHAI SNSAFDFIFI QFYNNPSCSA KRWVTNPKSV
260 270 280 290 300
TYTVDDWVKY IRKSGNPLAK LFIGLPASKS AAAKEDYLTP GEATKIVSTY
310 320 330 340 350
MAKYPSTFGG MMVWEATASE NNKLGGLPYA DIMKEVLLRC DPDPPTSTVT
360 370 380 390 400
STISASTSTQ TSSQSTTMET KTLSASTTPS SPSTVSPSST MQTTSTGSTS
410 420 430 440 450
TGTGTTSSQV TSSTTISTRS ASTETVTTRS QEPPSTTIST RPASTETVTT
460 470 480 490 500
RSQEPPSSTI STRSASTETV TTRSQEPPSS TISTRSASTE TSTSSQDSPS
510 520 530 540 550
TTISTKSAPT GTVTTRSQDL PSTTISTRSP ETETETVTTK SQDSPSITLS
560 570 580 590 600
TRSSSAETVS TRSQHSSSTT ISTKSAPTET GTTSEHSTSM PVSTRSASTE
610 620 630 640 650
TVITRSQNSD SQSMTVSTRS PSTESITTRS QGSPSETFST KSVPVDTIST
660 670 680 690 700
ELPSQTHSTT DSTPVSSSPT IPSGSTTIIP GTASDPVSAP TTTVPPNPTL
710 720 730 740 750
TLAPSSSTTE DRTTITTIIT TSYVTVCPTG FTTVTITYTT TYCPETASLT
760 770 780 790 800
PTQAPIPGAP APPPDGWTTI VTVCPQCAPT PTTVTLTVPT RSAFLPAPTE
810 820 830 840 850
TRPVVTVVPV PENPIKNVKP SESGDFVTVT TVAPATVTKT LEYNNPVDSD
860 870 880 890
VNVQPTGGSS PVEFEGGAMT VRSMDVVAKA LITAGAAVLG LFLGL
Length:895
Mass (Da):94,380
Last modified:October 3, 2006 - v2
Checksum:iC34ECF3D2609C3CF
GO

Sequence cautioni

The sequence EAS34994 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS34994.3. Sequence problems.
RefSeqiXP_001246577.2. XM_001246576.2.

Genome annotation databases

EnsemblFungiiEAS34994; EAS34994; CIMG_00348.
GeneIDi4565656.
KEGGicim:CIMG_00348.

Similar proteinsi

Entry informationi

Entry nameiCHI2_COCIM
AccessioniPrimary (citable) accession number: Q1EAR5
Secondary accession number(s): J3KGU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 10, 2017
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families