ID PYRF_COCIM Reviewed; 274 AA. AC Q1E9A1; J3KI15; Q9C0T0; Q9C144; Q9C145; DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2006, sequence version 1. DT 27-MAR-2024, entry version 87. DE RecName: Full=Orotidine 5'-phosphate decarboxylase; DE EC=4.1.1.23; DE AltName: Full=OMP decarboxylase; DE Short=OMPDCase; DE Short=OMPdecase; DE AltName: Full=Uridine 5'-monophosphate synthase; DE Short=UMP synthase; GN Name=URA3; ORFNames=CIMG_00862; OS Coccidioides immitis (strain RS) (Valley fever fungus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides. OX NCBI_TaxID=246410; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RS; RX PubMed=19717792; DOI=10.1101/gr.087551.108; RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T., RA Henn M.R., Birren B.W., Taylor J.W.; RT "Comparative genomic analyses of the human fungal pathogens Coccidioides RT and their relatives."; RL Genome Res. 19:1722-1731(2009). RN [2] RP GENOME REANNOTATION. RC STRAIN=RS; RX PubMed=20516208; DOI=10.1101/gr.103911.109; RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J., RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., RA Taylor J.W., Rounsley S.D.; RT "Population genomic sequencing of Coccidioides fungi reveals recent RT hybridization and transposon control."; RL Genome Res. 20:938-946(2010). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201, AND VARIANTS SER-75 AND RP VAL-76. RC STRAIN=RMSCC 1695 / CA3, RMSCC 2019 / CA4, and RMSCC 2267 / CA1; RX PubMed=9144263; DOI=10.1073/pnas.94.10.5478; RA Koufopanou V., Burt A., Taylor J.W.; RT "Concordance of gene genealogies reveals reproductive isolation in the RT pathogenic fungus Coccidioides immitis."; RL Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997). RN [4] RP ERRATUM OF PUBMED:9144263. RA Koufopanou V., Burt A., Taylor J.W.; RL Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998). CC -!- CATALYTIC ACTIVITY: CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23; CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10110}; CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; CC UMP from orotate: step 2/2. CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG704911; EAS35508.1; -; Genomic_DNA. DR EMBL; AJ292103; CAC35047.1; -; Genomic_DNA. DR EMBL; AJ292104; CAC35048.1; -; Genomic_DNA. DR EMBL; AJ292105; CAC35049.1; -; Genomic_DNA. DR RefSeq; XP_001247091.1; XM_001247090.2. DR AlphaFoldDB; Q1E9A1; -. DR SMR; Q1E9A1; -. DR STRING; 246410.Q1E9A1; -. DR GeneID; 4567662; -. DR KEGG; cim:CIMG_00862; -. DR VEuPathDB; FungiDB:CIMG_00862; -. DR InParanoid; Q1E9A1; -. DR OMA; CLIKTHI; -. DR OrthoDB; 922at2759; -. DR UniPathway; UPA00070; UER00120. DR Proteomes; UP000001261; Unassembled WGS sequence. DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd04725; OMP_decarboxylase_like; 1. DR Gene3D; 3.20.20.70; Aldolase class I; 1. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR014732; OMPdecase. DR InterPro; IPR018089; OMPdecase_AS. DR InterPro; IPR001754; OMPdeCOase_dom. DR InterPro; IPR011060; RibuloseP-bd_barrel. DR NCBIfam; TIGR01740; pyrF; 1. DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1. DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1. DR Pfam; PF00215; OMPdecase; 1. DR SMART; SM00934; OMPdecase; 1. DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1. DR PROSITE; PS00156; OMPDECASE; 1. PE 3: Inferred from homology; KW Decarboxylase; Lyase; Pyrimidine biosynthesis; Reference proteome. FT CHAIN 1..274 FT /note="Orotidine 5'-phosphate decarboxylase" FT /id="PRO_0000252292" FT ACT_SITE 95 FT /note="Proton donor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10110" FT BINDING 40 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 62..64 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 93..102 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 227 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 245 FT /ligand="substrate" FT /evidence="ECO:0000250" FT VARIANT 75 FT /note="T -> S (in strain: RMSCC 1695 / CA3)" FT /evidence="ECO:0000269|PubMed:9144263" FT VARIANT 76 FT /note="I -> V (in strain: RMSCC 1695 / CA3 and RMSCC 2267 FT /CA1)" FT /evidence="ECO:0000269|PubMed:9144263" SQ SEQUENCE 274 AA; 29606 MW; 9076091670B57E43 CRC64; MASKSQVPYE DRARDHPNPL ARRLFQIATE KQSNVAVSAD VTTTKELLDL ADRLGPYMVV LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG NTVQKQYHGG ALHISEWAHI VNATVLPGPG IIDALAQVAS APDFPHASDR GLLILATMTS KGSLATGQYT ELSVELARKY KGFVLGFVAS RSLEGVETAG KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF IISGRGIYAA PDPVDAARRY QKAGWDAYLK RVGR //