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Q1E9A1 (PYRF_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
ORF Names:CIMG_00862
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Orotidine 5'-phosphate decarboxylase
PRO_0000252292

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2271Substrate By similarity
Binding site2451Substrate By similarity

Natural variations

Natural variant751T → S in strain: RMSCC 1695 / CA3. Ref.3
Natural variant761I → V in strain: RMSCC 1695 / CA3 and RMSCC 2267 / CA1. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q1E9A1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 9076091670B57E43

FASTA27429,606
        10         20         30         40         50         60 
MASKSQVPYE DRARDHPNPL ARRLFQIATE KQSNVAVSAD VTTTKELLDL ADRLGPYMVV 

        70         80         90        100        110        120 
LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG NTVQKQYHGG ALHISEWAHI 

       130        140        150        160        170        180 
VNATVLPGPG IIDALAQVAS APDFPHASDR GLLILATMTS KGSLATGQYT ELSVELARKY 

       190        200        210        220        230        240 
KGFVLGFVAS RSLEGVETAG KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF 

       250        260        270 
IISGRGIYAA PDPVDAARRY QKAGWDAYLK RVGR 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS.
[2]"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control."
Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. expand/collapse author list , Lui A., Macdonald J.P., Priest M., Orbach M.J., Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., Taylor J.W., Rounsley S.D.
Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: RS.
[3]"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201, VARIANTS SER-75 AND VAL-76.
Strain: RMSCC 1695 / CA3, RMSCC 2019 / CA4 and RMSCC 2267 / CA1.
[4]Erratum
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704911 Genomic DNA. Translation: EAS35559.2.
AJ292103 Genomic DNA. Translation: CAC35047.1.
AJ292104 Genomic DNA. Translation: CAC35048.1.
AJ292105 Genomic DNA. Translation: CAC35049.1.
RefSeqXP_001247091.1. XM_001247090.1.
XP_001247142.1. XM_001247141.1.

3D structure databases

ProteinModelPortalQ1E9A1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4567330.
4567662.
KEGGcim:CIMG_00862.
cim:CIMG_00913.

Phylogenomic databases

KOK01591.
OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_COCIM
AccessionPrimary (citable) accession number: Q1E9A1
Secondary accession number(s): J3KI15 expand/collapse secondary AC list , Q9C0T0, Q9C144, Q9C145
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 11, 2006
Last modified: November 13, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways