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Q1E9A1

- PYRF_COCIM

UniProt

Q1E9A1 - PYRF_COCIM

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Active sitei95 – 951Proton donorPROSITE-ProRule annotation
    Binding sitei227 – 2271SubstrateBy similarity
    Binding sitei245 – 2451SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    ORF Names:CIMG_00862
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000252292Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ1E9A1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 643Substrate bindingBy similarity
    Regioni93 – 10210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    KOiK01591.
    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1E9A1-1 [UniParc]FASTAAdd to Basket

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    MASKSQVPYE DRARDHPNPL ARRLFQIATE KQSNVAVSAD VTTTKELLDL    50
    ADRLGPYMVV LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG 100
    NTVQKQYHGG ALHISEWAHI VNATVLPGPG IIDALAQVAS APDFPHASDR 150
    GLLILATMTS KGSLATGQYT ELSVELARKY KGFVLGFVAS RSLEGVETAG 200
    KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF IISGRGIYAA 250
    PDPVDAARRY QKAGWDAYLK RVGR 274
    Length:274
    Mass (Da):29,606
    Last modified:July 11, 2006 - v1
    Checksum:i9076091670B57E43
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751T → S in strain: RMSCC 1695 / CA3. 1 Publication
    Natural varianti76 – 761I → V in strain: RMSCC 1695 / CA3 and RMSCC 2267 / CA1. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS35559.2.
    AJ292103 Genomic DNA. Translation: CAC35047.1.
    AJ292104 Genomic DNA. Translation: CAC35048.1.
    AJ292105 Genomic DNA. Translation: CAC35049.1.
    RefSeqiXP_001247091.1. XM_001247090.1.
    XP_001247142.1. XM_001247141.1.

    Genome annotation databases

    GeneIDi4567330.
    4567662.
    KEGGicim:CIMG_00862.
    cim:CIMG_00913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS35559.2 .
    AJ292103 Genomic DNA. Translation: CAC35047.1 .
    AJ292104 Genomic DNA. Translation: CAC35048.1 .
    AJ292105 Genomic DNA. Translation: CAC35049.1 .
    RefSeqi XP_001247091.1. XM_001247090.1.
    XP_001247142.1. XM_001247141.1.

    3D structure databases

    ProteinModelPortali Q1E9A1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4567330.
    4567662.
    KEGGi cim:CIMG_00862.
    cim:CIMG_00913.

    Phylogenomic databases

    KOi K01591.
    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.
    3. "Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
      Koufopanou V., Burt A., Taylor J.W.
      Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201, VARIANTS SER-75 AND VAL-76.
      Strain: RMSCC 1695 / CA3, RMSCC 2019 / CA4 and RMSCC 2267 / CA1.
    4. Erratum
      Koufopanou V., Burt A., Taylor J.W.
      Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

    Entry informationi

    Entry nameiPYRF_COCIM
    AccessioniPrimary (citable) accession number: Q1E9A1
    Secondary accession number(s): J3KI15
    , Q9C0T0, Q9C144, Q9C145
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3