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Q1E9A1

- PYRF_COCIM

UniProt

Q1E9A1 - PYRF_COCIM

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei227 – 2271SubstrateBy similarity
Binding sitei245 – 2451SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:CIMG_00862
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000252292Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1E9A1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

InParanoidiQ1E9A1.
KOiK01591.
OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1E9A1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKSQVPYE DRARDHPNPL ARRLFQIATE KQSNVAVSAD VTTTKELLDL
60 70 80 90 100
ADRLGPYMVV LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG
110 120 130 140 150
NTVQKQYHGG ALHISEWAHI VNATVLPGPG IIDALAQVAS APDFPHASDR
160 170 180 190 200
GLLILATMTS KGSLATGQYT ELSVELARKY KGFVLGFVAS RSLEGVETAG
210 220 230 240 250
KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF IISGRGIYAA
260 270
PDPVDAARRY QKAGWDAYLK RVGR
Length:274
Mass (Da):29,606
Last modified:July 11, 2006 - v1
Checksum:i9076091670B57E43
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti75 – 751T → S in strain: RMSCC 1695 / CA3. 1 Publication
Natural varianti76 – 761I → V in strain: RMSCC 1695 / CA3 and RMSCC 2267 / CA1. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS35559.2.
AJ292103 Genomic DNA. Translation: CAC35047.1.
AJ292104 Genomic DNA. Translation: CAC35048.1.
AJ292105 Genomic DNA. Translation: CAC35049.1.
RefSeqiXP_001247091.1. XM_001247090.1.
XP_001247142.1. XM_001247141.1.

Genome annotation databases

GeneIDi4567330.
4567662.
KEGGicim:CIMG_00862.
cim:CIMG_00913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS35559.2 .
AJ292103 Genomic DNA. Translation: CAC35047.1 .
AJ292104 Genomic DNA. Translation: CAC35048.1 .
AJ292105 Genomic DNA. Translation: CAC35049.1 .
RefSeqi XP_001247091.1. XM_001247090.1.
XP_001247142.1. XM_001247141.1.

3D structure databases

ProteinModelPortali Q1E9A1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4567330.
4567662.
KEGGi cim:CIMG_00862.
cim:CIMG_00913.

Phylogenomic databases

InParanoidi Q1E9A1.
KOi K01591.
OrthoDBi EOG7CVQ76.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.
  3. "Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
    Koufopanou V., Burt A., Taylor J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201, VARIANTS SER-75 AND VAL-76.
    Strain: RMSCC 1695 / CA3, RMSCC 2019 / CA4 and RMSCC 2267 / CA1.
  4. Erratum
    Koufopanou V., Burt A., Taylor J.W.
    Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

Entry informationi

Entry nameiPYRF_COCIM
AccessioniPrimary (citable) accession number: Q1E9A1
Secondary accession number(s): J3KI15
, Q9C0T0, Q9C144, Q9C145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3