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Q1E8M9

- PMIP_COCIM

UniProt

Q1E8M9 - PMIP_COCIM

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
    Active sitei562 – 5621PROSITE-ProRule annotation
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi568 – 5681Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    ORF Names:CIMG_01084
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 795773Mitochondrial intermediate peptidasePRO_0000338579Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ1E8M9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK01410.
    K14816.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1E8M9-1 [UniParc]FASTAAdd to Basket

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    MLKTLNRRSW TCRQCIRILR RNAETRRYFQ GASAASPLCQ HTVSSSTSDK    50
    ARDDQTLRLI FDSEPFWREF SQPKSSTSKR TGLLQNQYLT GPDGFLQFAQ 100
    VSLQKCQKIV AKVIAASTLE DYRGMVRDLD RLSDLLCRVI DMAEFMKLNH 150
    PSPQIQDAAT QAYALMFEYM NVLNTTPELD AQLKRASADL NVTSHWSPEE 200
    KVAARVLLKD FSQSAIHLPP KDRQKFVALS NEISQLGPMF VTNRQPETDH 250
    VTVDKNKLRG MDPSLIQQLQ RWRKVAVPMF GDIPRIALYS VHDEETRKEI 300
    YVTSRTSSKV QIRRLETLLQ KRAELAKLAG FPSYAHMTLS DKMAKTPEAV 350
    VNFLEALNAS NRGQVQDELS QLLALKQADV PSATQLQPWD HAYYVHQYSA 400
    RHSRVRRSRE STLLPAFFSI GTVIQGLSRL FTRLYGIRLV PTETLPGEIW 450
    NPDVRRLDVV DESDRRLAVI YCDLFTRPYK SPNPTHFTLR GSREISQAEI 500
    AECADLSSSL HPNDGMATTI KPETNKLYQL PTVALICDFD QSESRSTPSL 550
    LNEHNLETLF HEMGHAVHSV LARTDLQTIS GTRCATDFVE LPSVIMENFA 600
    TAPEVLALYA RHWETNEPLP EHMVKSMELN RQSRVSMHGG MDNEVQILMA 650
    LLDQAYHSSR PLEPNFDSTR IYHDVYSTHS SLPDPPGSRT SWQGYFAHLV 700
    GYGATYYSYL FDRAIANKVW SDVFKGGELS TNRDAGERFK NEVLRWGGGR 750
    DGWNCVAGLL GNNPANDNGK LAEGGEEAMR EVGRWGLGLM GTSEL 795
    Length:795
    Mass (Da):89,923
    Last modified:July 11, 2006 - v1
    Checksum:i168DA75ECA56482F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS35809.2.
    RefSeqiXP_001247313.1. XM_001247312.1.
    XP_001247392.1. XM_001247391.1.

    Genome annotation databases

    GeneIDi4566657.
    4567355.
    KEGGicim:CIMG_01084.
    cim:CIMG_01163.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS35809.2 .
    RefSeqi XP_001247313.1. XM_001247312.1.
    XP_001247392.1. XM_001247391.1.

    3D structure databases

    ProteinModelPortali Q1E8M9.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4566657.
    4567355.
    KEGGi cim:CIMG_01084.
    cim:CIMG_01163.

    Phylogenomic databases

    KOi K01410.
    K14816.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiPMIP_COCIM
    AccessioniPrimary (citable) accession number: Q1E8M9
    Secondary accession number(s): J3KIK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3