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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi561 – 5611Zinc; catalyticPROSITE-ProRule annotation
Active sitei562 – 5621PROSITE-ProRule annotation
Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi568 – 5681Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CIMG_01084
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261 Componenti: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 795773Mitochondrial intermediate peptidasePRO_0000338579Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1E8M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiQ1E8M9.
KOiK01410.
K14816.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1E8M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKTLNRRSW TCRQCIRILR RNAETRRYFQ GASAASPLCQ HTVSSSTSDK
60 70 80 90 100
ARDDQTLRLI FDSEPFWREF SQPKSSTSKR TGLLQNQYLT GPDGFLQFAQ
110 120 130 140 150
VSLQKCQKIV AKVIAASTLE DYRGMVRDLD RLSDLLCRVI DMAEFMKLNH
160 170 180 190 200
PSPQIQDAAT QAYALMFEYM NVLNTTPELD AQLKRASADL NVTSHWSPEE
210 220 230 240 250
KVAARVLLKD FSQSAIHLPP KDRQKFVALS NEISQLGPMF VTNRQPETDH
260 270 280 290 300
VTVDKNKLRG MDPSLIQQLQ RWRKVAVPMF GDIPRIALYS VHDEETRKEI
310 320 330 340 350
YVTSRTSSKV QIRRLETLLQ KRAELAKLAG FPSYAHMTLS DKMAKTPEAV
360 370 380 390 400
VNFLEALNAS NRGQVQDELS QLLALKQADV PSATQLQPWD HAYYVHQYSA
410 420 430 440 450
RHSRVRRSRE STLLPAFFSI GTVIQGLSRL FTRLYGIRLV PTETLPGEIW
460 470 480 490 500
NPDVRRLDVV DESDRRLAVI YCDLFTRPYK SPNPTHFTLR GSREISQAEI
510 520 530 540 550
AECADLSSSL HPNDGMATTI KPETNKLYQL PTVALICDFD QSESRSTPSL
560 570 580 590 600
LNEHNLETLF HEMGHAVHSV LARTDLQTIS GTRCATDFVE LPSVIMENFA
610 620 630 640 650
TAPEVLALYA RHWETNEPLP EHMVKSMELN RQSRVSMHGG MDNEVQILMA
660 670 680 690 700
LLDQAYHSSR PLEPNFDSTR IYHDVYSTHS SLPDPPGSRT SWQGYFAHLV
710 720 730 740 750
GYGATYYSYL FDRAIANKVW SDVFKGGELS TNRDAGERFK NEVLRWGGGR
760 770 780 790
DGWNCVAGLL GNNPANDNGK LAEGGEEAMR EVGRWGLGLM GTSEL
Length:795
Mass (Da):89,923
Last modified:July 11, 2006 - v1
Checksum:i168DA75ECA56482F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35809.2.
RefSeqiXP_001247313.1. XM_001247312.1.
XP_001247392.1. XM_001247391.1.

Genome annotation databases

GeneIDi4566657.
4567355.
KEGGicim:CIMG_01084.
cim:CIMG_01163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS35809.2.
RefSeqiXP_001247313.1. XM_001247312.1.
XP_001247392.1. XM_001247391.1.

3D structure databases

ProteinModelPortaliQ1E8M9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4566657.
4567355.
KEGGicim:CIMG_01084.
cim:CIMG_01163.

Phylogenomic databases

InParanoidiQ1E8M9.
KOiK01410.
K14816.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiPMIP_COCIM
AccessioniPrimary (citable) accession number: Q1E8M9
Secondary accession number(s): J3KIK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 11, 2006
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.