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Q1E8M9

- PMIP_COCIM

UniProt

Q1E8M9 - PMIP_COCIM

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Protein

Mitochondrial intermediate peptidase

Gene
OCT1, CIMG_01084
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi561 – 5611Zinc; catalytic By similarity
Active sitei562 – 5621 By similarity
Metal bindingi565 – 5651Zinc; catalytic By similarity
Metal bindingi568 – 5681Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
ORF Names:CIMG_01084
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion Reviewed predictionAdd
BLAST
Chaini23 – 795773Mitochondrial intermediate peptidasePRO_0000338579Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1E8M9.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK01410.
K14816.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1E8M9-1 [UniParc]FASTAAdd to Basket

« Hide

MLKTLNRRSW TCRQCIRILR RNAETRRYFQ GASAASPLCQ HTVSSSTSDK    50
ARDDQTLRLI FDSEPFWREF SQPKSSTSKR TGLLQNQYLT GPDGFLQFAQ 100
VSLQKCQKIV AKVIAASTLE DYRGMVRDLD RLSDLLCRVI DMAEFMKLNH 150
PSPQIQDAAT QAYALMFEYM NVLNTTPELD AQLKRASADL NVTSHWSPEE 200
KVAARVLLKD FSQSAIHLPP KDRQKFVALS NEISQLGPMF VTNRQPETDH 250
VTVDKNKLRG MDPSLIQQLQ RWRKVAVPMF GDIPRIALYS VHDEETRKEI 300
YVTSRTSSKV QIRRLETLLQ KRAELAKLAG FPSYAHMTLS DKMAKTPEAV 350
VNFLEALNAS NRGQVQDELS QLLALKQADV PSATQLQPWD HAYYVHQYSA 400
RHSRVRRSRE STLLPAFFSI GTVIQGLSRL FTRLYGIRLV PTETLPGEIW 450
NPDVRRLDVV DESDRRLAVI YCDLFTRPYK SPNPTHFTLR GSREISQAEI 500
AECADLSSSL HPNDGMATTI KPETNKLYQL PTVALICDFD QSESRSTPSL 550
LNEHNLETLF HEMGHAVHSV LARTDLQTIS GTRCATDFVE LPSVIMENFA 600
TAPEVLALYA RHWETNEPLP EHMVKSMELN RQSRVSMHGG MDNEVQILMA 650
LLDQAYHSSR PLEPNFDSTR IYHDVYSTHS SLPDPPGSRT SWQGYFAHLV 700
GYGATYYSYL FDRAIANKVW SDVFKGGELS TNRDAGERFK NEVLRWGGGR 750
DGWNCVAGLL GNNPANDNGK LAEGGEEAMR EVGRWGLGLM GTSEL 795
Length:795
Mass (Da):89,923
Last modified:July 11, 2006 - v1
Checksum:i168DA75ECA56482F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS35809.2.
RefSeqiXP_001247313.1. XM_001247312.1.
XP_001247392.1. XM_001247391.1.

Genome annotation databases

GeneIDi4566657.
4567355.
KEGGicim:CIMG_01084.
cim:CIMG_01163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS35809.2 .
RefSeqi XP_001247313.1. XM_001247312.1.
XP_001247392.1. XM_001247391.1.

3D structure databases

ProteinModelPortali Q1E8M9.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4566657.
4567355.
KEGGi cim:CIMG_01084.
cim:CIMG_01163.

Phylogenomic databases

KOi K01410.
K14816.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiPMIP_COCIM
AccessioniPrimary (citable) accession number: Q1E8M9
Secondary accession number(s): J3KIK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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