Mitochondrial intermediate peptidase precursor - Coccidioides immitis (strain RS) (Valley fever fungus)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Mitochondrial intermediate peptidase
Short name=MIP
EC=3.4.24.59

Alternative name(s):
Octapeptidyl aminopeptidase

Gene names

Name:	OCT1
ORF Names:	CIMG_01084

Organism

Coccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides ›

Protein attributes

Sequence length	795 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.
Catalytic activity	Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.
Cofactor	Binds 1 zinc ion By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the peptidase M3 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 22

22

Mitochondrion Potential

Chain

23 – 795

773

Mitochondrial intermediate peptidase

PRO_0000338579

Sites

Active site

562

1

By similarity

Metal binding

561

1

Zinc; catalytic By similarity

Metal binding

565

1

Zinc; catalytic By similarity

Metal binding

568

1

Zinc; catalytic By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q1E8M9 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 168DA75ECA56482F
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FASTA

795

89,923

        10         20         30         40         50         60 
MLKTLNRRSW TCRQCIRILR RNAETRRYFQ GASAASPLCQ HTVSSSTSDK ARDDQTLRLI 

        70         80         90        100        110        120 
FDSEPFWREF SQPKSSTSKR TGLLQNQYLT GPDGFLQFAQ VSLQKCQKIV AKVIAASTLE 

       130        140        150        160        170        180 
DYRGMVRDLD RLSDLLCRVI DMAEFMKLNH PSPQIQDAAT QAYALMFEYM NVLNTTPELD 

       190        200        210        220        230        240 
AQLKRASADL NVTSHWSPEE KVAARVLLKD FSQSAIHLPP KDRQKFVALS NEISQLGPMF 

       250        260        270        280        290        300 
VTNRQPETDH VTVDKNKLRG MDPSLIQQLQ RWRKVAVPMF GDIPRIALYS VHDEETRKEI 

       310        320        330        340        350        360 
YVTSRTSSKV QIRRLETLLQ KRAELAKLAG FPSYAHMTLS DKMAKTPEAV VNFLEALNAS 

       370        380        390        400        410        420 
NRGQVQDELS QLLALKQADV PSATQLQPWD HAYYVHQYSA RHSRVRRSRE STLLPAFFSI 

       430        440        450        460        470        480 
GTVIQGLSRL FTRLYGIRLV PTETLPGEIW NPDVRRLDVV DESDRRLAVI YCDLFTRPYK 

       490        500        510        520        530        540 
SPNPTHFTLR GSREISQAEI AECADLSSSL HPNDGMATTI KPETNKLYQL PTVALICDFD 

       550        560        570        580        590        600 
QSESRSTPSL LNEHNLETLF HEMGHAVHSV LARTDLQTIS GTRCATDFVE LPSVIMENFA 

       610        620        630        640        650        660 
TAPEVLALYA RHWETNEPLP EHMVKSMELN RQSRVSMHGG MDNEVQILMA LLDQAYHSSR 

       670        680        690        700        710        720 
PLEPNFDSTR IYHDVYSTHS SLPDPPGSRT SWQGYFAHLV GYGATYYSYL FDRAIANKVW 

       730        740        750        760        770        780 
SDVFKGGELS TNRDAGERFK NEVLRWGGGR DGWNCVAGLL GNNPANDNGK LAEGGEEAMR 

       790 
EVGRWGLGLM GTSEL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control." Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. Rounsley S.D. Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG704911 Genomic DNA. Translation: EAS35809.2.
RefSeq	XP_001247313.1. XM_001247312.1. XP_001247392.1. XM_001247391.1.
3D structure databases
ProteinModelPortal	Q1E8M9.
ModBase	Search...
Protein family/group databases
MEROPS	M03.006.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4566657. 4567355.
KEGG	cim:CIMG_01084. cim:CIMG_01163.
Phylogenomic databases
KO	K01410. K14816.
Family and domain databases
Gene3D	1.10.1370.10. 2 hits. 3.40.390.10. 1 hit.
InterPro	IPR024079. MetalloPept_cat_dom. IPR024077. Neurolysin/TOP_dom2. IPR001567. Pept_M3A_M3B. [Graphical view]
Pfam	PF01432. Peptidase_M3. 1 hit. [Graphical view]
PROSITE	PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PMIP_COCIM

Accession

Primary (citable) accession number: Q1E8M9
Secondary accession number(s): J3KIK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents