Reviewed, UniProtKB/Swiss-Prot Q1E803 (HPPD_COCIM)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27
Alternative name(s):
    T-cell reactive protein

Gene names

Name:	TCRP
ORF Names:	CIMG_01310

Organism

Coccidioides immitis [Complete proteome]

Taxonomic identifier

5501 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.
Sequence caution	The sequence BAE20316.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20317.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20319.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20320.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20323.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	4-hydroxyphenylpyruvate dioxygenase		PRO_0000252281
Sites
	Metal binding	200	1	Iron By similarity
	Metal binding	283	1	Iron By similarity
	Metal binding	366	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1E803-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 7C440F0B51E82BA3	FASTA	399	45,290
	10 20 30 40 50 60 MAPAADSPTL QPAQPSDLNQ YRGYDHVHWY VGNAKQAATY YVTRMGFERV AYRGLETGSK 70 80 90 100 110 120 AVASHVVRNG NITFILTSPL RSVEQASRFP EDEALLKEIH AHLERHGDGV KDVAFEVDCV 130 140 150 160 170 180 ESVFSAAVRN GAEVVSDVRT VEDEDGQIKM ATIRTYGETT HTLIERSGYR GGFMPGYRME 190 200 210 220 230 240 SNVDATSKFL PKVVLERIDH CVGNQDWDEM ERVCDYYEKI LGFHRFWSVD DKDICTEFSA 250 260 270 280 290 300 LKSIVMASPN DIVKMPINEP AKGKKQSQIE EYVDFYNGAG VQHIALRTNN IIDAITNLKA 310 320 330 340 350 360 RGTEFIKVPE TYYEDMKIRL KRQGLVLDED FETLKSLDIL IDFDENGYLL QLFTKHLMDR 370 380 390 PTVFIEIIQR NNFSGFGAGN FRALFEAIER EQALRGTLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Coccidioides immitis RS genome." Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Oleary S., Orbach M.J., Galgiani J., Mandel M.A., Kellner E.M. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis." Koufopanou V., Burt A., Taylor J.W. Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed: 9144263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-362. Strain: RMSCC 2267 / CA1.
[3]	Erratum Koufopanou V., Burt A., Taylor J.W. Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)
[4]	"Reexamination of Coccidioides spp. reserved in the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a multiple gene analysis." Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K. Nippon Ishinkin Gakkai Zasshi 47:113-117(2006) [PubMed: 16699492] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-383. Strain: IFM 45815, IFM 45816, IFM 46868, IFM 50992 and IFM 50995.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH476726 Genomic DNA. Translation: EAS35956.1. AJ291969 Genomic DNA. Translation: CAC35134.1. AB232871 Genomic DNA. Translation: BAE20316.1. Sequence problems. AB232872 Genomic DNA. Translation: BAE20317.1. Sequence problems. AB232874 Genomic DNA. Translation: BAE20319.1. Sequence problems. AB232875 Genomic DNA. Translation: BAE20320.1. Sequence problems. AB232878 Genomic DNA. Translation: BAE20323.1. Sequence problems.
RefSeq	XP_001247539.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4567103.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_COCIM

Accession

Primary (citable) accession number: Q1E803
Secondary accession number(s): Q400Q2, Q9C0M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 11, 2006
Last modified:	November 25, 2008
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)