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Q1E5I0

- 3HAO_COCIM

UniProt

Q1E5I0 - 3HAO_COCIM

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501DioxygenUniRule annotation
Metal bindingi54 – 541Iron; catalyticUniRule annotation
Metal bindingi60 – 601Iron; catalyticUniRule annotation
Binding sitei60 – 601SubstrateUniRule annotation
Metal bindingi102 – 1021Iron; catalyticUniRule annotation
Binding sitei106 – 1061SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Metal bindingi131 – 1311Divalent metal cationUniRule annotation
Metal bindingi134 – 1341Divalent metal cationUniRule annotation
Metal bindingi168 – 1681Divalent metal cationUniRule annotation
Metal bindingi171 – 1711Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
ORF Names:CIMG_02183
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1921923-hydroxyanthranilate 3,4-dioxygenasePRO_0000361986Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1E5I0.
SMRiQ1E5I0. Positions 5-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

InParanoidiQ1E5I0.
KOiK00452.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1E5I0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAPALNLPK WLEENSHLLQ PPINNYCVYH PSAPATQGYT VMVVGGPNVR
60 70 80 90 100
TDYHINPTPE FFYQHRGSML LRTVDQSTSP PTFQDIPIHE GSLFLLPANT
110 120 130 140 150
PHCPVRFADT VGVVLEVPRP ENATDCMRWY CKGCGEIVWE KKFHCTDLGT
160 170 180 190
QVKEVVEEFA ADDEKRKCKA CGSVRSVRYE DGEVVQPPRA PE
Length:192
Mass (Da):21,611
Last modified:July 11, 2006 - v1
Checksum:i00503228EB6FC03A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS36973.2.
RefSeqiXP_001248412.1. XM_001248411.1.
XP_001248556.1. XM_001248555.1.

Genome annotation databases

GeneIDi4566696.
4567554.
KEGGicim:CIMG_02183.
cim:CIMG_02327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704911 Genomic DNA. Translation: EAS36973.2 .
RefSeqi XP_001248412.1. XM_001248411.1.
XP_001248556.1. XM_001248555.1.

3D structure databases

ProteinModelPortali Q1E5I0.
SMRi Q1E5I0. Positions 5-179.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4566696.
4567554.
KEGGi cim:CIMG_02183.
cim:CIMG_02327.

Phylogenomic databases

InParanoidi Q1E5I0.
KOi K00452.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry namei3HAO_COCIM
AccessioniPrimary (citable) accession number: Q1E5I0
Secondary accession number(s): J3KL46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3