Reviewed, UniProtKB/Swiss-Prot Q1E4I8 (KAD1_COCIM)

Names and origin

Protein names

Recommended name:
    Adenylate kinase 1
      Short name=AK 1
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 1
    Adenylate kinase cytosolic and mitochondrial

Gene names

Name:	ADK1
ORF Names:	CIMG_02525

Organism

Coccidioides immitis (Valley fever fungus) [Complete proteome]

Taxonomic identifier

5501 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Functions both in cytoplasm and mitochondrion intermembrane space By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm › cytosol By similarity. Mitochondrion intermembrane space By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Adenylate kinase 1		PRO_0000365670
Regions
	Nucleotide binding	52 – 60	9	ATP By similarity
	Nucleotide binding	75 – 104	30	AMP By similarity
Sites
	Binding site	76	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1E4I8-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: E916E7CAE7031208	FASTA	261	29,209
	10 20 30 40 50 60 MAPTKDETVD SLKSIIRDLE ARVVQLEQKL VHGEGSSKVN SLADGMRMVL MGPPGAGKGT 70 80 90 100 110 120 QAPKIKEKYC ICHLATGDML RSQVQKQTEL GKQAKKIMDQ GGLVSDDIMV NMIKHELETN 130 140 150 160 170 180 QECRNGFILD GFPRTVKQAE KLDEMLNARH QKLQHAVELR IDDELLVSRI TGRLIHPASG 190 200 210 220 230 240 RSYHKIFNPP KVPMTDDITG EPLIQRSDDN VEALKKRLVT YHSQTAPVVG YYKSTGIWKG 250 260 IDASQEPGQV WKSLLQVFEK K

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476726 Genomic DNA. Translation: EAS37171.1.
RefSeq	XP_001248754.1.
3D structure databases
SMR	Q1E4I8. Positions 44-260.
ModBase	Search...
Genome annotation databases
GeneID	4567412.
Phylogenomic databases
OrthoDB	EOG95DZ5W.
PhylomeDB	Q1E4I8.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD1_COCIM

Accession

Primary (citable) accession number: Q1E4I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 11, 2006
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)