Reviewed, UniProtKB/Swiss-Prot Q1E3R8 (CHI1_COCIM)

Names and origin

Protein names

Recommended name:
    Endochitinase 1
    EC=3.2.1.14
Alternative name(s):
    Complement-fixation antigen
      Short name=CF-antigen
      Short name=CF-AG

Gene names

Name:	CTS1
ORF Names:	CIMG_02795

Organism

Coccidioides immitis (Valley fever fungus) [Complete proteome]

Taxonomic identifier

5501 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.
Sequence similarities	Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
Sequence caution	The sequence BAE20296.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20297.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20299.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20300.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAE20303.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Chitin degradation Polysaccharide degradation
Domain	Signal
Ligand	Chitin-binding
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chitin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro chitin binding Inferred from electronic annotation. Source: UniProtKB-KW chitinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	By similarity
	Chain	18 – 427	410	Endochitinase 1		PRO_0000252286
Amino acid modifications
	Glycosylation	387	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1E3R8-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: F55F6DF8D0FCB15D	FASTA	427	47,398
	10 20 30 40 50 60 MRFLIGALLT LQTLVQASSM SSMPNSYPVP EAPAEGGFRS VVYFVNWAIY GRGHNPQDLK 70 80 90 100 110 120 ADQFTHILYA FANIRPSGEV YLSDTWADTD KHYPGDKWDE PGNNVYGCIK QMYLLKKNNR 130 140 150 160 170 180 NLKTLLSIGG WTYSPNFKTP ASTEEGRKKF ADTSLKLMKD LGFDGIDIDW EYPEDEKQAN 190 200 210 220 230 240 DFVLLLKACR EALDAYSAKH PNGKKFLLTI ASPAGPQNYN KLKLAEMDKY LDFWNLMAYD 250 260 270 280 290 300 FSGSWDKVSG HMSNVFPSTT KPESTPFSSD KAVKDYIKAG VPANKIVLGM PLYGRAFAST 310 320 330 340 350 360 DGIGTSFNGV GGGSWENGVW DYKDMPQQGA QVTELEDIAA SYSYDKNKRY LISYDTVKIA 370 380 390 400 410 420 GKKAEYITKN GMGGGMWWES SSDKTGNESL VGTVVNGLGG TGKLEQRENE LSYPESVYDN LKNGMPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Reexamination of Coccidioides spp. reserved in the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a multiple gene analysis." Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K. Nippon Ishinkin Gakkai Zasshi 47:113-117(2006) [PubMed: 16699492] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-151. Strain: IFM 45815, IFM 45816, IFM 46868, IFM 50992 and IFM 50995.
[3]	"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis." Koufopanou V., Burt A., Taylor J.W. Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed: 9144263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-145. Strain: RMSCC 1694 / CA2, RMSCC 2019 / CA4 and RMSCC 2267 / CA1.
[4]	Erratum Koufopanou V., Burt A., Taylor J.W. Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476726 Genomic DNA. Translation: EAS37441.1. AB232752 Genomic DNA. Translation: BAE20296.1. Sequence problems. AB232753 Genomic DNA. Translation: BAE20297.1. Sequence problems. AB232755 Genomic DNA. Translation: BAE20299.1. Sequence problems. AB232756 Genomic DNA. Translation: BAE20300.1. Sequence problems. AB232759 Genomic DNA. Translation: BAE20303.1. Sequence problems. AJ408865 Genomic DNA. Translation: CAC29131.1. AJ408866 Genomic DNA. Translation: CAC29132.1. AJ408867 Genomic DNA. Translation: CAC29133.1.
RefSeq	XP_001249024.1.
3D structure databases
SMR	Q1E3R8. Positions 36-427.
ModBase	Search...
Protein family/group databases
CAZy	GH18. Glycoside Hydrolase Family 18.
Genome annotation databases
GeneID	4566471.
Phylogenomic databases
OrthoDB	EOG97PZP0.
PhylomeDB	Q1E3R8.
Enzyme and pathway databases
BRENDA	3.2.1.14. 97654.
Family and domain databases
InterPro	IPR011583. Chitinase_II. IPR001223. Glyco_hydro18cat. IPR001579. Glyco_hydro_18_chit_AS. IPR017853. Glyco_hydro_catalytic_core. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00704. Glyco_hydro_18. 1 hit. [Graphical view]
SMART	SM00636. Glyco_18. 1 hit. [Graphical view]
PROSITE	PS01095. CHITINASE_18. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHI1_COCIM

Accession

Primary (citable) accession number: Q1E3R8
Secondary accession number(s): Q400W2, Q9C0M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 11, 2006
Last modified:	January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)