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Q1E306

- ROK1_COCIM

UniProt

Q1E306 - ROK1_COCIM

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Protein

ATP-dependent RNA helicase ROK1

Gene

ROK1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2488ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase ROK1 (EC:3.6.4.13)
Gene namesi
Name:ROK1
ORF Names:CIMG_03057
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730ATP-dependent RNA helicase ROK1PRO_0000256043Add
BLAST

Interactioni

Subunit structurei

Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ1E306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 442215Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini482 – 650169Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi172 – 20433Q motifAdd
BLAST
Motifi389 – 3924DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ1E306.
KOiK01176.
K14779.
OrthoDBiEOG74TX7R.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1E306-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAFKLLTRS IKLKGSQLGS SSISSHLPSA GEANNPQLFP ASEADKTRGT
60 70 80 90 100
KRKRESGEDT ELPNEIPVPD FFGSGSTAAE SPKAQRKRVT GKDADAEGQH
110 120 130 140 150
GEETSMPEEE RKSILKSHKI KMTDLRTPPF RAVDTDISGK KSKRKKKKVE
160 170 180 190 200
EPPPLTRKQL KAAQRLYPEP LTSFDKLRTR YHISRRLSDN IASQGYTVPT
210 220 230 240 250
EVQLGSLPLL LGNAPAPNER TADDESLRSQ SEREPDLLVV APTGSGKTLS
260 270 280 290 300
FMIPLINKIM KHHHDNPGLK EILAIVVAPT KELVAQIVNE GRKLTAGTGV
310 320 330 340 350
KVSAVRKGMR IVEERGQETR SLEEENDGDD STASSDEEIH SSEGEKSKDI
360 370 380 390 400
PLTKSDILVC TPLVLANALS DGGKRDVAPL PSVQKLVLDE ADVLLDPLFR
410 420 430 440 450
EQTLSIWRAC THPQLRVGLW SATMGSNIEE LTKSTIKERQ ELLGLKDESS
460 470 480 490 500
LIRLVVGLKD TAIPNISHKL VYAATEQGKL LGLRQLLHPT STSSSTTHLR
510 520 530 540 550
PPFLIFTQTI ARAIALHSEL MYDIPAEAGG SSRIAVLHSE LSDSKRSDVM
560 570 580 590 600
AGFRKGEIWV LITTDLLARG VDFRGINGVV NYDIPNSSAS YVHRVGRTGR
610 620 630 640 650
AGREGGVAVT FYTKEDIPYV KNIANVISAS ENLRGTEEGE RIPKWLLDAL
660 670 680 690 700
PSLSKNDKKD LKKYGVKARR PSTISDKTTS KKTRISTKSG FDRRMDNKRK
710 720 730
GAIKGSQRRK AREQLNDEES EDDVWNGIDD
Length:730
Mass (Da):80,375
Last modified:July 11, 2006 - v1
Checksum:iC7DBC691ACC18D98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704916 Genomic DNA. Translation: EAS32118.2.
RefSeqiXP_001243616.1. XM_001243615.1.
XP_001243701.1. XM_001243700.1.

Genome annotation databases

GeneIDi4563753.
4564331.
KEGGicim:CIMG_03057.
cim:CIMG_03142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704916 Genomic DNA. Translation: EAS32118.2 .
RefSeqi XP_001243616.1. XM_001243615.1.
XP_001243701.1. XM_001243700.1.

3D structure databases

ProteinModelPortali Q1E306.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4563753.
4564331.
KEGGi cim:CIMG_03057.
cim:CIMG_03142.

Phylogenomic databases

InParanoidi Q1E306.
KOi K01176.
K14779.
OrthoDBi EOG74TX7R.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiROK1_COCIM
AccessioniPrimary (citable) accession number: Q1E306
Secondary accession number(s): J3KAQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3