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Q1E306

- ROK1_COCIM

UniProt

Q1E306 - ROK1_COCIM

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Protein
ATP-dependent RNA helicase ROK1
Gene
ROK1, CIMG_03057
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2488ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase ROK1 (EC:3.6.4.13)
Gene namesi
Name:ROK1
ORF Names:CIMG_03057
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730ATP-dependent RNA helicase ROK1
PRO_0000256043Add
BLAST

Interactioni

Subunit structurei

Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ1E306.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini228 – 442215Helicase ATP-binding
Add
BLAST
Domaini482 – 650169Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi172 – 20433Q motif
Add
BLAST
Motifi389 – 3924DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

KOiK01176.
K14779.
OrthoDBiEOG74TX7R.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1E306-1 [UniParc]FASTAAdd to Basket

« Hide

MDAFKLLTRS IKLKGSQLGS SSISSHLPSA GEANNPQLFP ASEADKTRGT    50
KRKRESGEDT ELPNEIPVPD FFGSGSTAAE SPKAQRKRVT GKDADAEGQH 100
GEETSMPEEE RKSILKSHKI KMTDLRTPPF RAVDTDISGK KSKRKKKKVE 150
EPPPLTRKQL KAAQRLYPEP LTSFDKLRTR YHISRRLSDN IASQGYTVPT 200
EVQLGSLPLL LGNAPAPNER TADDESLRSQ SEREPDLLVV APTGSGKTLS 250
FMIPLINKIM KHHHDNPGLK EILAIVVAPT KELVAQIVNE GRKLTAGTGV 300
KVSAVRKGMR IVEERGQETR SLEEENDGDD STASSDEEIH SSEGEKSKDI 350
PLTKSDILVC TPLVLANALS DGGKRDVAPL PSVQKLVLDE ADVLLDPLFR 400
EQTLSIWRAC THPQLRVGLW SATMGSNIEE LTKSTIKERQ ELLGLKDESS 450
LIRLVVGLKD TAIPNISHKL VYAATEQGKL LGLRQLLHPT STSSSTTHLR 500
PPFLIFTQTI ARAIALHSEL MYDIPAEAGG SSRIAVLHSE LSDSKRSDVM 550
AGFRKGEIWV LITTDLLARG VDFRGINGVV NYDIPNSSAS YVHRVGRTGR 600
AGREGGVAVT FYTKEDIPYV KNIANVISAS ENLRGTEEGE RIPKWLLDAL 650
PSLSKNDKKD LKKYGVKARR PSTISDKTTS KKTRISTKSG FDRRMDNKRK 700
GAIKGSQRRK AREQLNDEES EDDVWNGIDD 730
Length:730
Mass (Da):80,375
Last modified:July 11, 2006 - v1
Checksum:iC7DBC691ACC18D98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704916 Genomic DNA. Translation: EAS32118.2.
RefSeqiXP_001243616.1. XM_001243615.1.
XP_001243701.1. XM_001243700.1.

Genome annotation databases

GeneIDi4563753.
4564331.
KEGGicim:CIMG_03057.
cim:CIMG_03142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704916 Genomic DNA. Translation: EAS32118.2 .
RefSeqi XP_001243616.1. XM_001243615.1.
XP_001243701.1. XM_001243700.1.

3D structure databases

ProteinModelPortali Q1E306.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4563753.
4564331.
KEGGi cim:CIMG_03057.
cim:CIMG_03142.

Phylogenomic databases

KOi K01176.
K14779.
OrthoDBi EOG74TX7R.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiROK1_COCIM
AccessioniPrimary (citable) accession number: Q1E306
Secondary accession number(s): J3KAQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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