Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1E306

- ROK1_COCIM

UniProt

Q1E306 - ROK1_COCIM

Protein

ATP-dependent RNA helicase ROK1

Gene

ROK1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi241 – 2488ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase ROK1 (EC:3.6.4.13)
    Gene namesi
    Name:ROK1
    ORF Names:CIMG_03057
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 730730ATP-dependent RNA helicase ROK1PRO_0000256043Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ1E306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini228 – 442215Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 650169Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi172 – 20433Q motifAdd
    BLAST
    Motifi389 – 3924DEAD box

    Domaini

    The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK01176.
    K14779.
    OrthoDBiEOG74TX7R.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1E306-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAFKLLTRS IKLKGSQLGS SSISSHLPSA GEANNPQLFP ASEADKTRGT    50
    KRKRESGEDT ELPNEIPVPD FFGSGSTAAE SPKAQRKRVT GKDADAEGQH 100
    GEETSMPEEE RKSILKSHKI KMTDLRTPPF RAVDTDISGK KSKRKKKKVE 150
    EPPPLTRKQL KAAQRLYPEP LTSFDKLRTR YHISRRLSDN IASQGYTVPT 200
    EVQLGSLPLL LGNAPAPNER TADDESLRSQ SEREPDLLVV APTGSGKTLS 250
    FMIPLINKIM KHHHDNPGLK EILAIVVAPT KELVAQIVNE GRKLTAGTGV 300
    KVSAVRKGMR IVEERGQETR SLEEENDGDD STASSDEEIH SSEGEKSKDI 350
    PLTKSDILVC TPLVLANALS DGGKRDVAPL PSVQKLVLDE ADVLLDPLFR 400
    EQTLSIWRAC THPQLRVGLW SATMGSNIEE LTKSTIKERQ ELLGLKDESS 450
    LIRLVVGLKD TAIPNISHKL VYAATEQGKL LGLRQLLHPT STSSSTTHLR 500
    PPFLIFTQTI ARAIALHSEL MYDIPAEAGG SSRIAVLHSE LSDSKRSDVM 550
    AGFRKGEIWV LITTDLLARG VDFRGINGVV NYDIPNSSAS YVHRVGRTGR 600
    AGREGGVAVT FYTKEDIPYV KNIANVISAS ENLRGTEEGE RIPKWLLDAL 650
    PSLSKNDKKD LKKYGVKARR PSTISDKTTS KKTRISTKSG FDRRMDNKRK 700
    GAIKGSQRRK AREQLNDEES EDDVWNGIDD 730
    Length:730
    Mass (Da):80,375
    Last modified:July 11, 2006 - v1
    Checksum:iC7DBC691ACC18D98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704916 Genomic DNA. Translation: EAS32118.2.
    RefSeqiXP_001243616.1. XM_001243615.1.
    XP_001243701.1. XM_001243700.1.

    Genome annotation databases

    GeneIDi4563753.
    4564331.
    KEGGicim:CIMG_03057.
    cim:CIMG_03142.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704916 Genomic DNA. Translation: EAS32118.2 .
    RefSeqi XP_001243616.1. XM_001243615.1.
    XP_001243701.1. XM_001243700.1.

    3D structure databases

    ProteinModelPortali Q1E306.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4563753.
    4564331.
    KEGGi cim:CIMG_03057.
    cim:CIMG_03142.

    Phylogenomic databases

    KOi K01176.
    K14779.
    OrthoDBi EOG74TX7R.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiROK1_COCIM
    AccessioniPrimary (citable) accession number: Q1E306
    Secondary accession number(s): J3KAQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3