Q1E180 (ARGI_COCIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginase
EC=3.5.3.1

Gene names

Name:	ARG
ORF Names:	CIMG_03683

Organism

Coccidioides immitis (strain RS) (Valley fever fungus)

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Subunit structure	Homotrimer By similarity.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Arginase		PRO_0000252280
Regions
	Region	143 – 147	5	Substrate binding By similarity
	Region	154 – 156	3	Substrate binding By similarity
Sites
	Metal binding	113	1	Manganese 1 By similarity
	Metal binding	141	1	Manganese 1 By similarity
	Metal binding	141	1	Manganese 2 By similarity
	Metal binding	143	1	Manganese 2 By similarity
	Metal binding	145	1	Manganese 1 By similarity
	Metal binding	247	1	Manganese 1 By similarity
	Metal binding	247	1	Manganese 2 By similarity
	Metal binding	249	1	Manganese 2 By similarity
	Binding site	200	1	Substrate By similarity
	Binding site	292	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1E180 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 9A8E42D2E8097D21	FASTA	322	35,114
	10 20 30 40 50 60 MTSPSTIKQK FIAKGHQLGV VAVGFSDGQP NQGVDPSGLI EAGLLDQLRD DLEYDIRHDG 70 80 90 100 110 120 KVHTYAEFVP EHDPNHRGMK KPRTVSAATQ QLSRQVYEHA REGRLVLTLG GDHSIAIGTI 130 140 150 160 170 180 SGTAKAIRER LGREMAVIWV DAHADINRPE DSDSGNIHGM PLAFLTGLAK DDNEDMFGWL 190 200 210 220 230 240 QPDNLISPRK LVYIGLRDVD RAEKRLLKEH GIKAFSMHDI DKYGIGRVVE MALAHIGQDT 250 260 270 280 290 300 PIHLSFDVDA LDPQWAPSTG TPVRGGLTLR EGDFIAESIH ETGSLVAMDL VEVNPTLETL 310 320 GASETIRAGC SLVRSALGDT LL

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476727 Genomic DNA. Translation: EAS32659.1.
RefSeq	XP_001244242.1. XM_001244241.1.
3D structure databases
ProteinModelPortal	Q1E180.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4563496.
KEGG	cim:CIMG_03683.
Family and domain databases
InterPro	IPR014033. Arginase_subgr. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_domain. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
KO	K01476.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PIRSF	PIRSF036979. Arginase. 1 hit.
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. RocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI_COCIM

Accession

Primary (citable) accession number: Q1E180

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	July 11, 2006
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program