Histone-lysine N-methyltransferase, H3 lysine-36 specific - Coccidioides immitis (strain RS) (Valley fever fungus)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 2

Gene names

Name:	SET2
ORF Names:	CIMG_06210

Organism

Coccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides ›

Protein attributes

Sequence length	1011 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Domain	The AWS and SET domains are necessary for transcription repression By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 1 post-SET domain. Contains 1 SET domain. Contains 1 WW domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Molecular function	Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, elongation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone methyltransferase activity (H3-K36 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1011

1011

Histone-lysine N-methyltransferase, H3 lysine-36 specific

PRO_0000269785

Regions

Domain

146 – 201

56

AWS

Domain

202 – 324

123

SET

Domain

327 – 343

17

Post-SET

Domain

604 – 635

32

WW

Compositional bias

664 – 798

135

Lys-rich

Compositional bias

936 – 950

15

Pro-rich

Sequences

Sequence

Length

Mass (Da)

Tools

Q1DU03 [UniParc].

Last modified January 9, 2013. Version 2.
Checksum: BE481233774FD88D
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FASTA

1,011

113,904

        10         20         30         40         50         60 
MAGHDDEEAR IETVKDAVTD MKLERQSSTE SVAPNGILDT ITPKDEPNGH LSSKPSTPSL 

        70         80         90        100        110        120 
KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA RSASQKLPPR AAPLFTDLPD 

       130        140        150        160        170        180 
KTTEATSTFQ LMEVCTYANK YLGYTEHAMD CDCAEEWDAA TCRNTACGED SDCINRATKM 

       190        200        210        220        230        240 
ECFGDCGCGD SCQNQRFQRR EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP 

       250        260        270        280        290        300 
QFRRRMIQYD EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR 

       310        320        330        340        350        360 
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER ATKLSHATIE 

       370        380        390        400        410        420 
ALGIDDPDGW DTAVARRPRK KKAGEDDEEY VDSLQPKSLD ENGVTKVMAA LMQCKEKWIA 

       430        440        450        460        470        480 
VKLLGRIQRC EDERVRHRVV RMHGYQILNS QLNTWKDDFN VVLQILDILD KFPRLTRNKI 

       490        500        510        520        530        540 
IDSKIEGTVS PLQECDDERV AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE 

       550        560        570        580        590        600 
RRETAKDDRK PNSSKSRSRS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR 

       610        620        630        640        650        660 
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE KTLQDIIDGI 

       670        680        690        700        710        720 
MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE EKQKKLYENT LFPHVKYIVD 

       730        740        750        760        770        780 
KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN RVEDPTKISD KQVKQVKKYC KEYFDKAVAK 

       790        800        810        820        830        840 
HRAYEEKKAE RKSKGSVKAT TSATIDKAET TSTKAPPQFD GAAETGDEDS DVQLSDAEYE 

       850        860        870        880        890        900 
DGQEESSHHS GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD 

       910        920        930        940        950        960 
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP ENIESENEND 

       970        980        990       1000       1010 
KDQEELQDYD VQEANWGKED NIAIQSPSHS PFPAQSISNH SNTARETDSH S

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control." Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. Rounsley S.D. Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG704912 Genomic DNA. Translation: EAS30985.2.
RefSeq	XP_001242568.1. XM_001242567.1.
3D structure databases
ProteinModelPortal	Q1DU03.
ModBase	Search...
Proteomic databases
PRIDE	Q1DU03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4560739.
KEGG	cim:CIMG_06464.
Phylogenomic databases
KO	K11584.
Family and domain databases
InterPro	IPR006560. AWS. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR017923. TFIIS_N. IPR001202. WW_dom. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF47676. TFIIS_conserved. 1 hit.
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET2_COCIM

Accession

Primary (citable) accession number: Q1DU03
Secondary accession number(s): J3K868

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2013
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents