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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
ORF Names:CIMG_06210
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269785Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 20156AWSPROSITE-ProRule annotationAdd
BLAST
Domaini203 – 320118SETPROSITE-ProRule annotationAdd
BLAST
Domaini327 – 34317Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini604 – 63532WWPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi664 – 798135Lys-richAdd
BLAST
Compositional biasi936 – 95015Pro-richAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ1DU03.
KOiK11584.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DU03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGHDDEEAR IETVKDAVTD MKLERQSSTE SVAPNGILDT ITPKDEPNGH
60 70 80 90 100
LSSKPSTPSL KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA
110 120 130 140 150
RSASQKLPPR AAPLFTDLPD KTTEATSTFQ LMEVCTYANK YLGYTEHAMD
160 170 180 190 200
CDCAEEWDAA TCRNTACGED SDCINRATKM ECFGDCGCGD SCQNQRFQRR
210 220 230 240 250
EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP QFRRRMIQYD
260 270 280 290 300
EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR
310 320 330 340 350
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER
360 370 380 390 400
ATKLSHATIE ALGIDDPDGW DTAVARRPRK KKAGEDDEEY VDSLQPKSLD
410 420 430 440 450
ENGVTKVMAA LMQCKEKWIA VKLLGRIQRC EDERVRHRVV RMHGYQILNS
460 470 480 490 500
QLNTWKDDFN VVLQILDILD KFPRLTRNKI IDSKIEGTVS PLQECDDERV
510 520 530 540 550
AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE RRETAKDDRK
560 570 580 590 600
PNSSKSRSRS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR
610 620 630 640 650
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE
660 670 680 690 700
KTLQDIIDGI MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE
710 720 730 740 750
EKQKKLYENT LFPHVKYIVD KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN
760 770 780 790 800
RVEDPTKISD KQVKQVKKYC KEYFDKAVAK HRAYEEKKAE RKSKGSVKAT
810 820 830 840 850
TSATIDKAET TSTKAPPQFD GAAETGDEDS DVQLSDAEYE DGQEESSHHS
860 870 880 890 900
GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD
910 920 930 940 950
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP
960 970 980 990 1000
ENIESENEND KDQEELQDYD VQEANWGKED NIAIQSPSHS PFPAQSISNH
1010
SNTARETDSH S
Length:1,011
Mass (Da):113,904
Last modified:January 9, 2013 - v2
Checksum:iBE481233774FD88D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA. Translation: EAS30985.2.
RefSeqiXP_001242568.1. XM_001242567.1.

Genome annotation databases

GeneIDi4560739.
KEGGicim:CIMG_06464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA. Translation: EAS30985.2.
RefSeqiXP_001242568.1. XM_001242567.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4560739.
KEGGicim:CIMG_06464.

Phylogenomic databases

InParanoidiQ1DU03.
KOiK11584.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiSET2_COCIM
AccessioniPrimary (citable) accession number: Q1DU03
Secondary accession number(s): J3K868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2013
Last modified: January 7, 2015
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.