Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q1DU03 (SET2_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 2
Gene names
Name:SET2
ORF Names:CIMG_06210
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length1011 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

Contains 1 AWS domain.

Contains 1 post-SET domain.

Contains 1 SET domain.

Contains 1 WW domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10111011Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269785

Regions

Domain146 – 20156AWS
Domain203 – 320118SET
Domain327 – 34317Post-SET
Domain604 – 63532WW
Compositional bias664 – 798135Lys-rich
Compositional bias936 – 95015Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q1DU03 [UniParc].

Last modified January 9, 2013. Version 2.
Checksum: BE481233774FD88D

FASTA1,011113,904
        10         20         30         40         50         60 
MAGHDDEEAR IETVKDAVTD MKLERQSSTE SVAPNGILDT ITPKDEPNGH LSSKPSTPSL 

        70         80         90        100        110        120 
KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA RSASQKLPPR AAPLFTDLPD 

       130        140        150        160        170        180 
KTTEATSTFQ LMEVCTYANK YLGYTEHAMD CDCAEEWDAA TCRNTACGED SDCINRATKM 

       190        200        210        220        230        240 
ECFGDCGCGD SCQNQRFQRR EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP 

       250        260        270        280        290        300 
QFRRRMIQYD EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR 

       310        320        330        340        350        360 
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER ATKLSHATIE 

       370        380        390        400        410        420 
ALGIDDPDGW DTAVARRPRK KKAGEDDEEY VDSLQPKSLD ENGVTKVMAA LMQCKEKWIA 

       430        440        450        460        470        480 
VKLLGRIQRC EDERVRHRVV RMHGYQILNS QLNTWKDDFN VVLQILDILD KFPRLTRNKI 

       490        500        510        520        530        540 
IDSKIEGTVS PLQECDDERV AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE 

       550        560        570        580        590        600 
RRETAKDDRK PNSSKSRSRS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR 

       610        620        630        640        650        660 
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE KTLQDIIDGI 

       670        680        690        700        710        720 
MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE EKQKKLYENT LFPHVKYIVD 

       730        740        750        760        770        780 
KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN RVEDPTKISD KQVKQVKKYC KEYFDKAVAK 

       790        800        810        820        830        840 
HRAYEEKKAE RKSKGSVKAT TSATIDKAET TSTKAPPQFD GAAETGDEDS DVQLSDAEYE 

       850        860        870        880        890        900 
DGQEESSHHS GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD 

       910        920        930        940        950        960 
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP ENIESENEND 

       970        980        990       1000       1010 
KDQEELQDYD VQEANWGKED NIAIQSPSHS PFPAQSISNH SNTARETDSH S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704912 Genomic DNA. Translation: EAS30985.2.
RefSeqXP_001242568.1. XM_001242567.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4560739.
KEGGcim:CIMG_06464.

Phylogenomic databases

KOK11584.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET2_COCIM
AccessionPrimary (citable) accession number: Q1DU03
Secondary accession number(s): J3K868
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families