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Q1DU03

- SET2_COCIM

UniProt

Q1DU03 - SET2_COCIM

Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 2 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, elongation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 2
    Gene namesi
    Name:SET2
    ORF Names:CIMG_06210
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10111011Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269785Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini146 – 20156AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 320118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini327 – 34317Post-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini604 – 63532WWPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi664 – 798135Lys-richAdd
    BLAST
    Compositional biasi936 – 95015Pro-richAdd
    BLAST

    Domaini

    The AWS and SET domains are necessary for transcription repression.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation
    Contains 1 WW domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK11584.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR017923. TFIIS_N.
    IPR001202. WW_dom.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view]
    SUPFAMiSSF47676. SSF47676. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1DU03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGHDDEEAR IETVKDAVTD MKLERQSSTE SVAPNGILDT ITPKDEPNGH     50
    LSSKPSTPSL KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA 100
    RSASQKLPPR AAPLFTDLPD KTTEATSTFQ LMEVCTYANK YLGYTEHAMD 150
    CDCAEEWDAA TCRNTACGED SDCINRATKM ECFGDCGCGD SCQNQRFQRR 200
    EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP QFRRRMIQYD 250
    EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR 300
    MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER 350
    ATKLSHATIE ALGIDDPDGW DTAVARRPRK KKAGEDDEEY VDSLQPKSLD 400
    ENGVTKVMAA LMQCKEKWIA VKLLGRIQRC EDERVRHRVV RMHGYQILNS 450
    QLNTWKDDFN VVLQILDILD KFPRLTRNKI IDSKIEGTVS PLQECDDERV 500
    AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE RRETAKDDRK 550
    PNSSKSRSRS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR 600
    RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE 650
    KTLQDIIDGI MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE 700
    EKQKKLYENT LFPHVKYIVD KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN 750
    RVEDPTKISD KQVKQVKKYC KEYFDKAVAK HRAYEEKKAE RKSKGSVKAT 800
    TSATIDKAET TSTKAPPQFD GAAETGDEDS DVQLSDAEYE DGQEESSHHS 850
    GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD 900
    DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP 950
    ENIESENEND KDQEELQDYD VQEANWGKED NIAIQSPSHS PFPAQSISNH 1000
    SNTARETDSH S 1011
    Length:1,011
    Mass (Da):113,904
    Last modified:January 9, 2013 - v2
    Checksum:iBE481233774FD88D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704912 Genomic DNA. Translation: EAS30985.2.
    RefSeqiXP_001242568.1. XM_001242567.1.

    Genome annotation databases

    GeneIDi4560739.
    KEGGicim:CIMG_06464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704912 Genomic DNA. Translation: EAS30985.2 .
    RefSeqi XP_001242568.1. XM_001242567.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4560739.
    KEGGi cim:CIMG_06464.

    Phylogenomic databases

    KOi K11584.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    IPR017923. TFIIS_N.
    IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    SM00456. WW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47676. SSF47676. 1 hit.
    SSF51045. SSF51045. 1 hit.
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiSET2_COCIM
    AccessioniPrimary (citable) accession number: Q1DU03
    Secondary accession number(s): J3K868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3