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Q1DU03

- SET2_COCIM

UniProt

Q1DU03 - SET2_COCIM

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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene
SET2, CIMG_06210
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
ORF Names:CIMG_06210
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10111011Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269785Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 20156AWSAdd
BLAST
Domaini203 – 320118SETAdd
BLAST
Domaini327 – 34317Post-SETAdd
BLAST
Domaini604 – 63532WWAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi664 – 798135Lys-richAdd
BLAST
Compositional biasi936 – 95015Pro-richAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similaritiesi

Contains 1 AWS domain.
Contains 1 post-SET domain.
Contains 1 SET domain.
Contains 1 WW domain.

Phylogenomic databases

KOiK11584.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DU03-1 [UniParc]FASTAAdd to Basket

« Hide

MAGHDDEEAR IETVKDAVTD MKLERQSSTE SVAPNGILDT ITPKDEPNGH     50
LSSKPSTPSL KPPKSRSRSS NSLAKDEVPE EKVGGDITIK QEPGQPPKLA 100
RSASQKLPPR AAPLFTDLPD KTTEATSTFQ LMEVCTYANK YLGYTEHAMD 150
CDCAEEWDAA TCRNTACGED SDCINRATKM ECFGDCGCGD SCQNQRFQRR 200
EYAKVSVIKT EKKGYGLRAD CDLRPNEFIF EYIGEVINEP QFRRRMIQYD 250
EEGIKHFYFM SLNKGEFVDA TKKGNLGRFC NHSCNPNCYV DKWVVGEKLR 300
MGIFAERYIK AGEELVFNYN VDRYGADPQP CYCGEPNCTG FIGGKTQTER 350
ATKLSHATIE ALGIDDPDGW DTAVARRPRK KKAGEDDEEY VDSLQPKSLD 400
ENGVTKVMAA LMQCKEKWIA VKLLGRIQRC EDERVRHRVV RMHGYQILNS 450
QLNTWKDDFN VVLQILDILD KFPRLTRNKI IDSKIEGTVS PLQECDDERV 500
AEKAKALLEI WSALEVGYRI PRMKRDPAAV NNTPTANHYE RRETAKDDRK 550
PNSSKSRSRS RSRSRSVDVT RNAPRGPAAL TRGGGKGHMH SYRPGQRPFR 600
RPFNPLPKGW FAAESNGRTY YYSATGETTW SRPTAPAVQP PPPPKRESKE 650
KTLQDIIDGI MNAKENTPKA KDKSATPATP ADAKIPEKKE HKEKWRSYSE 700
EKQKKLYENT LFPHVKYIVD KFKHKLPKDD LKRYAKEVAK KLVNSDFKNN 750
RVEDPTKISD KQVKQVKKYC KEYFDKAVAK HRAYEEKKAE RKSKGSVKAT 800
TSATIDKAET TSTKAPPQFD GAAETGDEDS DVQLSDAEYE DGQEESSHHS 850
GLKRKRTDDE DFENDHENGG VSPTKRQRSA SLPIIPPPPP PMSPSNLVLD 900
DGSREALKRQ RTEGAEDDEY GDSTISSGKR QRSETPPPPP PPPPPADIPP 950
ENIESENEND KDQEELQDYD VQEANWGKED NIAIQSPSHS PFPAQSISNH 1000
SNTARETDSH S 1011
Length:1,011
Mass (Da):113,904
Last modified:January 9, 2013 - v2
Checksum:iBE481233774FD88D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704912 Genomic DNA. Translation: EAS30985.2.
RefSeqiXP_001242568.1. XM_001242567.1.

Genome annotation databases

GeneIDi4560739.
KEGGicim:CIMG_06464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704912 Genomic DNA. Translation: EAS30985.2 .
RefSeqi XP_001242568.1. XM_001242567.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4560739.
KEGGi cim:CIMG_06464.

Phylogenomic databases

KOi K11584.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view ]
SUPFAMi SSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiSET2_COCIM
AccessioniPrimary (citable) accession number: Q1DU03
Secondary accession number(s): J3K868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2013
Last modified: April 16, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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