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Protein

Mitochondrial glycine transporter

Gene

CIMG_07070

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:CIMG_07070
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000001261 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CIMG_07070

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 49Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei77 – 103Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei144 – 169Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei197 – 220Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei251 – 277Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei306 – 324Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789341 – 347Mitochondrial glycine transporterAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi246410.XP_001243174.1

Structurei

3D structure databases

ProteinModelPortaliQ1DRJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 102Solcar 1UniRule annotationAdd BLAST85
Repeati138 – 222Solcar 2UniRule annotationAdd BLAST85
Repeati247 – 331Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
InParanoidiQ1DRJ3
KOiK15118
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q1DRJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNGSHSSVQ LKSSTYLSKP TFHFAAGLLS GLTSSILLQP ADLLKTRVQQ
60 70 80 90 100
SRETAALLPT IRSILASPHP IQGLWRGTLP SALRTGFGSA LYFTSLNTLR
110 120 130 140 150
TAVAADDPGY LFRGGHGSKP QNGNSPSGVS ASSALPKLSH TANLITGAVA
160 170 180 190 200
RVAAGFVMMP VTVLKVRYES DYYAYRSLWG AAKDIVRHEG VRGLFAGFGA
210 220 230 240 250
TAIRDAPYAG LYVVFYEQSK RSLASLLGAS SPSARSTPTE QQKSPPSTAS
260 270 280 290 300
INFISGALAA GLATTITNPF DVVKTRVQLM PSKYKNMMRA TALMLREDGM
310 320 330 340
RSLFGGLGLR MGRKALSSAL AWTVYEELIM WAEKRWAEEQ RDVKGVL
Length:347
Mass (Da):37,252
Last modified:July 11, 2006 - v1
Checksum:i14B89677CD262DE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA Translation: EAS31591.3
RefSeqiXP_001243174.1, XM_001243173.2

Genome annotation databases

EnsemblFungiiEAS31591; EAS31591; CIMG_07070
GeneIDi4561746
KEGGicim:CIMG_07070

Similar proteinsi

Entry informationi

Entry nameiS2538_COCIM
AccessioniPrimary (citable) accession number: Q1DRJ3
Secondary accession number(s): J3K3B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 11, 2006
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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