Reviewed,
UniProtKB/Swiss-Prot Q1DP56 (MTLD_COCIM)
Last modified
November 3, 2009.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Mannitol-1-phosphate 5-dehydrogenase Short name=M1PDH Short name=MPDH Short name=MPD EC=1.1.1.17 | ||
| Gene names |
| ||
| Organism | Coccidioides immitis (Valley fever fungus) [Complete proteome] | ||
| Taxonomic identifier | 5501 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides |
Protein attributes
| Sequence length | 388 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity. |
| Catalytic activity | D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the mannitol dehydrogenase family. |
| Sequence caution | The sequence EAS29161.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. Taylor J.W.Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS. |
Cross-references
Sequence databases | |
|---|---|
| CH476729 Genomic DNA. Translation: EAS29161.1. Sequence problems. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view] |
| PRINTS | PR00084. MTLDHDRGNASE. |
| PROSITE | PS00974. MANNITOL_DHGENASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MTLD_COCIM | ||||||||
| Accession | Primary (citable) accession number: Q1DP56 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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