Q1DN93 (ATG1_COCIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase ATG1
EC=2.7.11.1

Alternative name(s):
Autophagy-related protein 1

Gene names

Name:	ATG1
ORF Names:	CIMG_08220

Organism

Coccidioides immitis (strain RS) (Valley fever fungus)

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length	969 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 969	969	Serine/threonine-protein kinase ATG1		PRO_0000317793
Regions
	Domain	30 – 335	306	Protein kinase
	Nucleotide binding	36 – 44	9	ATP By similarity
Sites
	Active site	173	1	Proton acceptor By similarity
	Binding site	59	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1DN93 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: BFEC1C5E1941FFE2	FASTA	969	106,042
	10 20 30 40 50 60 MAALQSPKTS SRRSKGDGDG DTRDVILGKY TKIEEIGRGS FATVYQGIHN KYRSCVAIKA 70 80 90 100 110 120 VNISSLNPKL KDNLKLEIEI LKGLQHPHIV ALIDCDESTS CIHLVMEYCA LGDLSLFIRK 130 140 150 160 170 180 RDTLSKHELT RDMIAKYPNP PAGGLNEVIV RHFLKQLASA LQFLRTKDLI HRDLKPQNLL 190 200 210 220 230 240 LNPPPSTYAK GLLRIVPYKT REDSFTPLVG VESLPMLKIA DFGFARSLPA TSLAETLCGS 250 260 270 280 290 300 PLYMAPEILR YEKYDAKADL WSVGTVLFEM VVGKSPFRAG NHVDLLRKIE QGEDNIRFPI 310 320 330 340 350 360 QTEASPPLKK LIRSLLKRNP VERLSFKDFF ESSVVKGNIP GLVDEDLQAQ RERDSRLAAH 370 380 390 400 410 420 AARRDSLPSR TSDGKLEDRP PSSASSPRPP PSNFTRPATS PAVRHVGSRE NPDLQRVAVK 430 440 450 460 470 480 ARKASVASVT GSPSKEELRD HNAKGPVTEQ PGPTSPAKER ATTRKNSSDQ RIDDILDSER 490 500 510 520 530 540 ERAAQDVAFE RDYVVVEKRA VEVNAFADEL AASPRFQQQQ QQQLIPKQAG AIVRRATTTA 550 560 570 580 590 600 TPQLSSSPRD AMSRAVATAY NRPRTGSTHN RHNSYDRRYG PSPTSATSAI SKALNKASGR 610 620 630 640 650 660 LFGVSFSPPL ALTKAGRSPP IGYNAFPAYP LAEGNLAVVG DGAKIQPPLD EDTKVLHIIE 670 680 690 700 710 720 EIATRSDVVY GFAEVKYKQL APLTPSMQAD TAIKPVVSPE VVDTPEANDT GLTVDAIFTL 730 740 750 760 770 780 SEEALVLYVK ALSLLAKSMD IAGAWWARKN RGETIGNSPN VNVGCRVNNV VQWVRNRFNE 790 800 810 820 830 840 VLQKAEYSRL KLLDAQRQLP YDHAHHASQV GRVSVGALAH SSDQVVISSG ITAEKLMYDR 850 860 870 880 890 900 ALEMSRTAAI NELTGEDLPG CEIAYMTAIR MLEAVLDSDE DHQLSGERAG EAANTVSNEE 910 920 930 940 950 960 NGEVNGLQGE DREIVAKLVA SIRIRLTALK KKIALMTKRT SAPAMVSPAR TPACQPPAAS PVVPQASSR

References

[1]

"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH476729 Genomic DNA. Translation: EAS29474.1.
RefSeq	XP_001241057.1. XM_001241056.1.
3D structure databases
ProteinModelPortal	Q1DN93.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4559351.
KEGG	cim:CIMG_08220.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR022708. Ser/Thr_kinase_C. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K08269.
Pfam	PF12063. DUF3543. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_COCIM

Accession

Primary (citable) accession number: Q1DN93

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 11, 2006
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program