Q1DLC7 (NTE1_COCIM) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 40.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Lysophospholipase NTE1 EC=3.1.1.5 Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog | ||||
| Gene names |
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| Organism | Coccidioides immitis (strain RS) (Valley fever fungus) | ||||
| Taxonomic identifier | 246410 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides |
Protein attributes
| Sequence length | 1569 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity. |
| Catalytic activity | 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
| Enzyme regulation | Inhibited by organophosphorus esters By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the NTE family. Contains 2 cyclic nucleotide-binding domains. Contains 1 patatin domain. |
| Sequence caution | The sequence EAS30140.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid degradation Lipid metabolism |
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Repeat Transmembrane Transmembrane helix |
| Molecular function | Hydrolase |
| Gene Ontology (GO) | |
| Biological process | lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylcholine metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | lysophospholipase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1569 | 1569 | Lysophospholipase NTE1 | PRO_0000295317 | |||||
Regions | |||||||||
| Topological domain | 1 – 93 | 93 | Cytoplasmic By similarity | ||||||
| Transmembrane | 94 – 114 | 21 | Helical; Potential | ||||||
| Topological domain | 115 – 145 | 31 | Lumenal By similarity | ||||||
| Transmembrane | 146 – 166 | 21 | Helical; Potential | ||||||
| Topological domain | 167 – 1569 | 1403 | Cytoplasmic By similarity | ||||||
| Domain | 1266 – 1430 | 165 | Patatin | ||||||
| Nucleotide binding | 731 – 850 | 120 | cNMP 1 | ||||||
| Nucleotide binding | 888 – 1008 | 121 | cNMP 2 | ||||||
| Motif | 1297 – 1301 | 5 | GXSXG | ||||||
| Compositional bias | 41 – 88 | 48 | Pro-rich | ||||||
Sites | |||||||||
| Active site | 1299 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N.  Taylor J.W.Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CH476729 Genomic DNA. Translation: EAS30140.1. Sequence problems. |
| RefSeq | XP_001241723.1. XM_001241722.1. |
3D structure databases | |
| ProteinModelPortal | Q1DLC7. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4560690. |
| KEGG | cim:CIMG_08886. |
Family and domain databases | |
| InterPro | IPR016035. Acyl_Trfase/lysoPLipase. IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR001423. LysoPLipase_patatin_CS. IPR002641. Patatin/PLipase_A2-rel. IPR014710. RmlC-like_jellyroll. [Graphical view] |
| Gene3D | G3DSA:2.60.120.10. RmlC-like_jellyroll. 5 hits. |
| KO | K14676. |
| Pfam | PF00027. cNMP_binding. 2 hits. PF01734. Patatin. 1 hit. [Graphical view] |
| SMART | SM00100. cNMP. 1 hit. [Graphical view] |
| SUPFAM | SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF51206. cNMP_binding. 3 hits. |
| PROSITE | PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 2 hits. PS01237. UPF0028. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NTE1_COCIM | ||||||||
| Accession | Primary (citable) accession number: Q1DLC7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |