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Q1DLC7

- NTE1_COCIM

UniProt

Q1DLC7 - NTE1_COCIM

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 3 (09 Jan 2013)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1305 – 13051By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi737 – 856120cNMP 1Add
    BLAST
    Nucleotide bindingi894 – 1014121cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    ORF Names:CIMG_08886
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15751575Lysophospholipase NTE1PRO_0000295317Add
    BLAST

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9999CytoplasmicBy similarityAdd
    BLAST
    Topological domaini121 – 15131LumenalBy similarityAdd
    BLAST
    Topological domaini173 – 15751403CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1272 – 1436165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1303 – 13075GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi47 – 9448Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1DLC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLTTTMPAA VAPDPPAQLA VSSRSLSDSS DAAGASRTSS SCRASSPSHC     50
    PTHAWNPDPP PSSLQPVFSF SPSLPPPCPS PAISSCPPNT LSPPNLLQGI 100
    VSQLAMASYI GRLLLYLFQV VPSLLYWAIT FTTITVPTAL FTLFSMSLTF 150
    TMNFTTLLII VLLLVSTVSW FIRYRFLNIY SRLPPEPQRK EPEIDLFPDS 200
    QDGDSKPGLS NYLDEFLSAI KVFGYLERPV FHELTRTMQT RKLIAGETLL 250
    LEEEKGFCLV VDGLVQIFVK SIQERDDDRD GWQLDEAVED SVDEDDEIRR 300
    RGHQGYQLLT EVKNGASMSS LFSILSLFSE DIKLRHNEDM ESSSSSFNNV 350
    PAPDSNPMSP ALLLESPTRV SFPDQRDIPT QPSADTLPKV SPLALEGSPG 400
    PFEHDPKPRG HRRKRPSRPK RAKSVHPDIL ARAMVDTTIA IIPASAFRRL 450
    TRVYPKATAH IIQVILTRLQ RVTFATAHSY LGLTTEVLSI EQQMTKYTSF 500
    DLPNHLRGAA LDKLKSKFTK EKERLGPEDG TKGIALHNPA LNRRRRSSSS 550
    LRKDAALHAK LTAVRGKGSA SNPIRYGDHE STGVSPGDLL STIQLSRFGP 600
    RYGSERLNGR SVFYDAASGM KTPAGGPPSP LATPGQPLFR FPAQNVTFQR 650
    QDSLDQDAIF RESILDCMMK ALGLTGSTQD ALRKTHNSGD ASPHLVSYDS 700
    RRQKAVFNNA FGFIDPYDGF GDGDSESLMS MSVTSAGGTS PVHNLRTELQ 750
    DEIEIVYFPK GSVLIEQGEH NPGLYYVIDG FLDVGIPVNE KGEDLIGSSR 800
    RPTAEDILLP ITGNASRVSS TLGTAHNQRK KASRRSLYMV KPGGVEGYIG 850
    SITSYRSFTD VTAKTDVYVG FLPRAVLERI ADRYPLVMLT MAKRLTTVLP 900
    RLILHIDFAL EWVQVNAGQV IHHQGDESDA IYIVLNGRLR AVLDKGDGKV 950
    SVLGEYGQGD SVGELEVMTE STRPGTLHAI RDTELAKFPR TLFNSLAQEH 1000
    PGITIQISKL IAQRMRHIID NPLEKGSDKG SPDSAKPTTS TLNLRTVAVL 1050
    PVTAGIPVVE FGNRLLNAFN QVGVTNGVTS LHQADILNHL GRHAFSKMGK 1100
    LKLAQYLADL EERYGMVLYV GDTSVNAPWT QTCIAQADCI LLVALAEGSP 1150
    AIGEYERFLL GMKTTARKEL VLLHAERYSQ PGLTRQWLKN RMWINGGHHH 1200
    IQMAFRLTAE PVHPETKRLG AVLKQRVQVI QAEIQKYTSR RIRQTPVYST 1250
    STPVKGDFHR LARRLCGKSV GLVLGGGGAR GIAHIGVIKA LEEAGIPIDI 1300
    IGGTSIGSFI GALYARDADV VPAYGRAKKF SGRMASMWRF ALDLTYPSAS 1350
    YTTGHEFNRG IFKAFGNSHI EDFWLEFYCN TTNISKSRLE FHSSGYAWRY 1400
    VRASMSLAGL IPPLCDEGNM LLDGGYVDNL TVARMKSLGA DVIFAVDVGA 1450
    IDDNTPQGYG DSLSGFWALV NRWNPFSSLP NPPTLSEIQA RLAYVSSVDA 1500
    LERAKSTPGC LYMRPPIDAF GTLDFAKFDE IYQVGYKFGK EFLDRLKNEG 1550
    GLPIQEETEE KKKLRRTMAP RRASI 1575
    Length:1,575
    Mass (Da):173,384
    Last modified:January 9, 2013 - v3
    Checksum:i1E6B773A6278AC61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704913 Genomic DNA. Translation: EAS27977.2.
    RefSeqiXP_001239560.1. XM_001239559.1.

    Genome annotation databases

    GeneIDi4558296.
    KEGGicim:CIMG_09181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704913 Genomic DNA. Translation: EAS27977.2 .
    RefSeqi XP_001239560.1. XM_001239559.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4558296.
    KEGGi cim:CIMG_09181.

    Phylogenomic databases

    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiNTE1_COCIM
    AccessioniPrimary (citable) accession number: Q1DLC7
    Secondary accession number(s): J3K1S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: January 9, 2013
    Last modified: October 1, 2014
    This is version 53 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3