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Q1DLC7 (NTE1_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
ORF Names:CIMG_08886
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length1575 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15751575Lysophospholipase NTE1
PRO_0000295317

Regions

Topological domain1 – 9999Cytoplasmic By similarity
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 15131Lumenal By similarity
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 15751403Cytoplasmic By similarity
Domain1272 – 1436165Patatin
Nucleotide binding737 – 856120cNMP 1
Nucleotide binding894 – 1014121cNMP 2
Motif1303 – 13075GXSXG
Compositional bias47 – 9448Pro-rich

Sites

Active site13051 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1DLC7 [UniParc].

Last modified January 9, 2013. Version 3.
Checksum: 1E6B773A6278AC61

FASTA1,575173,384
        10         20         30         40         50         60 
MNLTTTMPAA VAPDPPAQLA VSSRSLSDSS DAAGASRTSS SCRASSPSHC PTHAWNPDPP 

        70         80         90        100        110        120 
PSSLQPVFSF SPSLPPPCPS PAISSCPPNT LSPPNLLQGI VSQLAMASYI GRLLLYLFQV 

       130        140        150        160        170        180 
VPSLLYWAIT FTTITVPTAL FTLFSMSLTF TMNFTTLLII VLLLVSTVSW FIRYRFLNIY 

       190        200        210        220        230        240 
SRLPPEPQRK EPEIDLFPDS QDGDSKPGLS NYLDEFLSAI KVFGYLERPV FHELTRTMQT 

       250        260        270        280        290        300 
RKLIAGETLL LEEEKGFCLV VDGLVQIFVK SIQERDDDRD GWQLDEAVED SVDEDDEIRR 

       310        320        330        340        350        360 
RGHQGYQLLT EVKNGASMSS LFSILSLFSE DIKLRHNEDM ESSSSSFNNV PAPDSNPMSP 

       370        380        390        400        410        420 
ALLLESPTRV SFPDQRDIPT QPSADTLPKV SPLALEGSPG PFEHDPKPRG HRRKRPSRPK 

       430        440        450        460        470        480 
RAKSVHPDIL ARAMVDTTIA IIPASAFRRL TRVYPKATAH IIQVILTRLQ RVTFATAHSY 

       490        500        510        520        530        540 
LGLTTEVLSI EQQMTKYTSF DLPNHLRGAA LDKLKSKFTK EKERLGPEDG TKGIALHNPA 

       550        560        570        580        590        600 
LNRRRRSSSS LRKDAALHAK LTAVRGKGSA SNPIRYGDHE STGVSPGDLL STIQLSRFGP 

       610        620        630        640        650        660 
RYGSERLNGR SVFYDAASGM KTPAGGPPSP LATPGQPLFR FPAQNVTFQR QDSLDQDAIF 

       670        680        690        700        710        720 
RESILDCMMK ALGLTGSTQD ALRKTHNSGD ASPHLVSYDS RRQKAVFNNA FGFIDPYDGF 

       730        740        750        760        770        780 
GDGDSESLMS MSVTSAGGTS PVHNLRTELQ DEIEIVYFPK GSVLIEQGEH NPGLYYVIDG 

       790        800        810        820        830        840 
FLDVGIPVNE KGEDLIGSSR RPTAEDILLP ITGNASRVSS TLGTAHNQRK KASRRSLYMV 

       850        860        870        880        890        900 
KPGGVEGYIG SITSYRSFTD VTAKTDVYVG FLPRAVLERI ADRYPLVMLT MAKRLTTVLP 

       910        920        930        940        950        960 
RLILHIDFAL EWVQVNAGQV IHHQGDESDA IYIVLNGRLR AVLDKGDGKV SVLGEYGQGD 

       970        980        990       1000       1010       1020 
SVGELEVMTE STRPGTLHAI RDTELAKFPR TLFNSLAQEH PGITIQISKL IAQRMRHIID 

      1030       1040       1050       1060       1070       1080 
NPLEKGSDKG SPDSAKPTTS TLNLRTVAVL PVTAGIPVVE FGNRLLNAFN QVGVTNGVTS 

      1090       1100       1110       1120       1130       1140 
LHQADILNHL GRHAFSKMGK LKLAQYLADL EERYGMVLYV GDTSVNAPWT QTCIAQADCI 

      1150       1160       1170       1180       1190       1200 
LLVALAEGSP AIGEYERFLL GMKTTARKEL VLLHAERYSQ PGLTRQWLKN RMWINGGHHH 

      1210       1220       1230       1240       1250       1260 
IQMAFRLTAE PVHPETKRLG AVLKQRVQVI QAEIQKYTSR RIRQTPVYST STPVKGDFHR 

      1270       1280       1290       1300       1310       1320 
LARRLCGKSV GLVLGGGGAR GIAHIGVIKA LEEAGIPIDI IGGTSIGSFI GALYARDADV 

      1330       1340       1350       1360       1370       1380 
VPAYGRAKKF SGRMASMWRF ALDLTYPSAS YTTGHEFNRG IFKAFGNSHI EDFWLEFYCN 

      1390       1400       1410       1420       1430       1440 
TTNISKSRLE FHSSGYAWRY VRASMSLAGL IPPLCDEGNM LLDGGYVDNL TVARMKSLGA 

      1450       1460       1470       1480       1490       1500 
DVIFAVDVGA IDDNTPQGYG DSLSGFWALV NRWNPFSSLP NPPTLSEIQA RLAYVSSVDA 

      1510       1520       1530       1540       1550       1560 
LERAKSTPGC LYMRPPIDAF GTLDFAKFDE IYQVGYKFGK EFLDRLKNEG GLPIQEETEE 

      1570 
KKKLRRTMAP RRASI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704913 Genomic DNA. Translation: EAS27977.2.
RefSeqXP_001239560.1. XM_001239559.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4558296.
KEGGcim:CIMG_09181.

Phylogenomic databases

OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_COCIM
AccessionPrimary (citable) accession number: Q1DLC7
Secondary accession number(s): J3K1S9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 9, 2013
Last modified: February 19, 2014
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families