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Q1DLC7

- NTE1_COCIM

UniProt

Q1DLC7 - NTE1_COCIM

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1305 – 13051By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi737 – 856120cNMP 1Add
BLAST
Nucleotide bindingi894 – 1014121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CIMG_08886
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999CytoplasmicBy similarityAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Topological domaini121 – 15131LumenalBy similarityAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Topological domaini173 – 15751403CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15751575Lysophospholipase NTE1PRO_0000295317Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1272 – 1436165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1303 – 13075GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 9448Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ1DLC7.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DLC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLTTTMPAA VAPDPPAQLA VSSRSLSDSS DAAGASRTSS SCRASSPSHC
60 70 80 90 100
PTHAWNPDPP PSSLQPVFSF SPSLPPPCPS PAISSCPPNT LSPPNLLQGI
110 120 130 140 150
VSQLAMASYI GRLLLYLFQV VPSLLYWAIT FTTITVPTAL FTLFSMSLTF
160 170 180 190 200
TMNFTTLLII VLLLVSTVSW FIRYRFLNIY SRLPPEPQRK EPEIDLFPDS
210 220 230 240 250
QDGDSKPGLS NYLDEFLSAI KVFGYLERPV FHELTRTMQT RKLIAGETLL
260 270 280 290 300
LEEEKGFCLV VDGLVQIFVK SIQERDDDRD GWQLDEAVED SVDEDDEIRR
310 320 330 340 350
RGHQGYQLLT EVKNGASMSS LFSILSLFSE DIKLRHNEDM ESSSSSFNNV
360 370 380 390 400
PAPDSNPMSP ALLLESPTRV SFPDQRDIPT QPSADTLPKV SPLALEGSPG
410 420 430 440 450
PFEHDPKPRG HRRKRPSRPK RAKSVHPDIL ARAMVDTTIA IIPASAFRRL
460 470 480 490 500
TRVYPKATAH IIQVILTRLQ RVTFATAHSY LGLTTEVLSI EQQMTKYTSF
510 520 530 540 550
DLPNHLRGAA LDKLKSKFTK EKERLGPEDG TKGIALHNPA LNRRRRSSSS
560 570 580 590 600
LRKDAALHAK LTAVRGKGSA SNPIRYGDHE STGVSPGDLL STIQLSRFGP
610 620 630 640 650
RYGSERLNGR SVFYDAASGM KTPAGGPPSP LATPGQPLFR FPAQNVTFQR
660 670 680 690 700
QDSLDQDAIF RESILDCMMK ALGLTGSTQD ALRKTHNSGD ASPHLVSYDS
710 720 730 740 750
RRQKAVFNNA FGFIDPYDGF GDGDSESLMS MSVTSAGGTS PVHNLRTELQ
760 770 780 790 800
DEIEIVYFPK GSVLIEQGEH NPGLYYVIDG FLDVGIPVNE KGEDLIGSSR
810 820 830 840 850
RPTAEDILLP ITGNASRVSS TLGTAHNQRK KASRRSLYMV KPGGVEGYIG
860 870 880 890 900
SITSYRSFTD VTAKTDVYVG FLPRAVLERI ADRYPLVMLT MAKRLTTVLP
910 920 930 940 950
RLILHIDFAL EWVQVNAGQV IHHQGDESDA IYIVLNGRLR AVLDKGDGKV
960 970 980 990 1000
SVLGEYGQGD SVGELEVMTE STRPGTLHAI RDTELAKFPR TLFNSLAQEH
1010 1020 1030 1040 1050
PGITIQISKL IAQRMRHIID NPLEKGSDKG SPDSAKPTTS TLNLRTVAVL
1060 1070 1080 1090 1100
PVTAGIPVVE FGNRLLNAFN QVGVTNGVTS LHQADILNHL GRHAFSKMGK
1110 1120 1130 1140 1150
LKLAQYLADL EERYGMVLYV GDTSVNAPWT QTCIAQADCI LLVALAEGSP
1160 1170 1180 1190 1200
AIGEYERFLL GMKTTARKEL VLLHAERYSQ PGLTRQWLKN RMWINGGHHH
1210 1220 1230 1240 1250
IQMAFRLTAE PVHPETKRLG AVLKQRVQVI QAEIQKYTSR RIRQTPVYST
1260 1270 1280 1290 1300
STPVKGDFHR LARRLCGKSV GLVLGGGGAR GIAHIGVIKA LEEAGIPIDI
1310 1320 1330 1340 1350
IGGTSIGSFI GALYARDADV VPAYGRAKKF SGRMASMWRF ALDLTYPSAS
1360 1370 1380 1390 1400
YTTGHEFNRG IFKAFGNSHI EDFWLEFYCN TTNISKSRLE FHSSGYAWRY
1410 1420 1430 1440 1450
VRASMSLAGL IPPLCDEGNM LLDGGYVDNL TVARMKSLGA DVIFAVDVGA
1460 1470 1480 1490 1500
IDDNTPQGYG DSLSGFWALV NRWNPFSSLP NPPTLSEIQA RLAYVSSVDA
1510 1520 1530 1540 1550
LERAKSTPGC LYMRPPIDAF GTLDFAKFDE IYQVGYKFGK EFLDRLKNEG
1560 1570
GLPIQEETEE KKKLRRTMAP RRASI
Length:1,575
Mass (Da):173,384
Last modified:January 9, 2013 - v3
Checksum:i1E6B773A6278AC61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704913 Genomic DNA. Translation: EAS27977.2.
RefSeqiXP_001239560.1. XM_001239559.1.

Genome annotation databases

GeneIDi4558296.
KEGGicim:CIMG_09181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704913 Genomic DNA. Translation: EAS27977.2 .
RefSeqi XP_001239560.1. XM_001239559.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4558296.
KEGGi cim:CIMG_09181.

Phylogenomic databases

InParanoidi Q1DLC7.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiNTE1_COCIM
AccessioniPrimary (citable) accession number: Q1DLC7
Secondary accession number(s): J3K1S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 9, 2013
Last modified: October 29, 2014
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3