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Reviewed, UniProtKB/Swiss-Prot Q1DLC7 (NTE1_COCIM)

Last modified June 16, 2009. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lysophospholipase NTE1
    EC=3.1.1.5
Alternative name(s):
    Neuropathy target esterase homolog
    Intracellular phospholipase B
Gene names
Name: NTE1
ORF Names: CIMG_08886
OrganismCoccidioides immitis [Complete proteome]
Taxonomic identifier5501 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

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Protein attributes

Sequence length1569 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence caution

The sequence EAS30140.1 differs from that shown. Reason: Erroneous gene model prediction.

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Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
   DomainRepeat
Transmembrane
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylcholine metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionlysophospholipase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15691569Lysophospholipase NTE1
PRO_0000295317

Regions

Topological domain1 – 9393Cytoplasmic By similarity
Transmembrane94 – 11421 Potential
Topological domain115 – 14531Lumenal By similarity
Transmembrane146 – 16621 Potential
Topological domain167 – 15691403Cytoplasmic By similarity
Domain1266 – 1430165Patatin
Nucleotide binding731 – 850120cNMP 1
Nucleotide binding888 – 1008121cNMP 2
Motif1297 – 13015GXSXG
Compositional bias41 – 8848Pro-rich

Sites

Active site12991 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q1DLC7-1 [UniParc].

Last modified July 24, 2007. Version 2.
Checksum: 026AEFA28D8B2B2B

FASTA1,569172,722
        10         20         30         40         50         60 
MPAAVAPDPP AQLAVSSRSL SDSSDAAGAS RTSSSCRASS PSHCPTHAWN PDPPPSSLQP 

        70         80         90        100        110        120 
VFSFSPSLPP PCPSPAISSC PPNTLSPPNL LQGIVSQLAM ASYIGRLLLY LFQVVPSLLY 

       130        140        150        160        170        180 
WAITFTTITV PTALFTLFSM SLTFTMNFTT LLIIVLLLVS TVSWFIRYRF LNIYSRLPPE 

       190        200        210        220        230        240 
PQRKEPEIDL FPDSQDGDSK PGLSNYLDEF LSAIKVFGYL ERPVFHELTR TMQTRKLIAG 

       250        260        270        280        290        300 
ETLLLEEEKG FCLVVDGLVQ IFVKSIQERD DDRDGWQLDE AVEDSVDEDD EIRRRGHQGY 

       310        320        330        340        350        360 
QLLTEVKNGA SMSSLFSILS LFSEDIKLRH NEDMESSSSS FNNVPAPDSN PMSPALLLES 

       370        380        390        400        410        420 
PTRVSFPDQR DIPTQPSADT LPKVSPLALE GSPGPFEHDP KPRGHRRKRP SRPKRAKSVH 

       430        440        450        460        470        480 
PDILARAMVD TTIAIIPASA FRRLTRVYPK ATAHIIQVIL TRLQRVTFAT AHSYLGLTTE 

       490        500        510        520        530        540 
VLSIEQQMTK YTSFDLPNHL RGAALDKLKS KFTKEKERLG PEDGTKGIAL HNPALNRRRR 

       550        560        570        580        590        600 
SSSSLRKDAA LHAKLTAVRG KGSASNPIRY GDHESTGVSP GDLLSTIQLS RFGPRYGSER 

       610        620        630        640        650        660 
LNGRSVFYDA ASGMKTPAGG PPSPLATPGQ PLFRFPAQNV TFQRQDSLDQ DAIFRESILD 

       670        680        690        700        710        720 
CMMKALGLTG STQDALRKTH NSGDASPHLV SYDSRRQKAV FNNAFGFIDP YDGFGDGDSE 

       730        740        750        760        770        780 
SLMSMSVTSA GGTSPVHNLR TELQDEIEIV YFPKGSVLIE QGEHNPGLYY VIDGFLDVGI 

       790        800        810        820        830        840 
PVNEKGEDLI GSSRRPTAED ILLPITGNAS RVSSTLGTAH NQRKKASRRS LYMVKPGGVE 

       850        860        870        880        890        900 
GYIGSITSYR SFTDVTAKTD VYVGFLPRAV LERIADRYPL VMLTMAKRLT TVLPRLILHI 

       910        920        930        940        950        960 
DFALEWVQVN AGQVIHHQGD ESDAIYIVLN GRLRAVLDKG DGKVSVLGEY GQGDSVGELE 

       970        980        990       1000       1010       1020 
VMTESTRPGT LHAIRDTELA KFPRTLFNSL AQEHPGITIQ ISKLIAQRMR HIIDNPLEKG 

      1030       1040       1050       1060       1070       1080 
SDKGSPDSAK PTTSTLNLRT VAVLPVTAGI PVVEFGNRLL NAFNQVGVTN GVTSLHQADI 

      1090       1100       1110       1120       1130       1140 
LNHLGRHAFS KMGKLKLAQY LADLEERYGM VLYVGDTSVN APWTQTCIAQ ADCILLVALA 

      1150       1160       1170       1180       1190       1200 
EGSPAIGEYE RFLLGMKTTA RKELVLLHAE RYSQPGLTRQ WLKNRMWING GHHHIQMAFR 

      1210       1220       1230       1240       1250       1260 
LTAEPVHPET KRLGAVLKQR VQVIQAEIQK YTSRRIRQTP VYSTSTPVKG DFHRLARRLC 

      1270       1280       1290       1300       1310       1320 
GKSVGLVLGG GGARGIAHIG VIKALEEAGI PIDIIGGTSI GSFIGALYAR DADVVPAYGR 

      1330       1340       1350       1360       1370       1380 
AKKFSGRMAS MWRFALDLTY PSASYTTGHE FNRGIFKAFG NSHIEDFWLE FYCNTTNISK 

      1390       1400       1410       1420       1430       1440 
SRLEFHSSGY AWRYVRASMS LAGLIPPLCD EGNMLLDGGY VDNLTVARMK SLGADVIFAV 

      1450       1460       1470       1480       1490       1500 
DVGAIDDNTP QGYGDSLSGF WALVNRWNPF SSLPNPPTLS EIQARLAYVS SVDALERAKS 

      1510       1520       1530       1540       1550       1560 
TPGCLYMRPP IDAFGTLDFA KFDEIYQVGY KFGKEFLDRL KNEGGLPIQE ETEEKKKLRR 


TMAPRRASI

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References

[1]"Annotation of the Coccidioides immitis RS genome."
Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Henn M., Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K. expand/collapse author list , Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Oleary S., Orbach M.J., Galgiani J., Mandel M.A., Kellner E.M.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS.

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Cross-references

Sequence databases

CH476729 Genomic DNA. Translation: EAS30140.1. Sequence problems.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA3.1.1.5. 97654.

Family and domain databases

InterProIPR000595. cNMP_bd.
IPR018488. cNMP_bd_CS.
IPR001423. Lysophospholipase_patatin_CS.
IPR002641. Patatin.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
PROSITEPS00888. CNMP_BINDING_1. False negative.
PS00889. CNMP_BINDING_2. False negative.
PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNTE1_COCIM
AccessionPrimary (citable) accession number: Q1DLC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 16, 2009
This is version 21 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents