SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1DLC7

- NTE1_COCIM

UniProt

Q1DLC7 - NTE1_COCIM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lysophospholipase NTE1
Gene
NTE1, CIMG_08886
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1305 – 13051 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi737 – 856120cNMP 1
Add
BLAST
Nucleotide bindingi894 – 1014121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
ORF Names:CIMG_08886
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9999Cytoplasmic By similarity
Add
BLAST
Transmembranei100 – 12021Helical; Reviewed prediction
Add
BLAST
Topological domaini121 – 15131Lumenal By similarity
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Topological domaini173 – 15751403Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15751575Lysophospholipase NTE1
PRO_0000295317Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1272 – 1436165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1303 – 13075GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 9448Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1DLC7-1 [UniParc]FASTAAdd to Basket

« Hide

MNLTTTMPAA VAPDPPAQLA VSSRSLSDSS DAAGASRTSS SCRASSPSHC     50
PTHAWNPDPP PSSLQPVFSF SPSLPPPCPS PAISSCPPNT LSPPNLLQGI 100
VSQLAMASYI GRLLLYLFQV VPSLLYWAIT FTTITVPTAL FTLFSMSLTF 150
TMNFTTLLII VLLLVSTVSW FIRYRFLNIY SRLPPEPQRK EPEIDLFPDS 200
QDGDSKPGLS NYLDEFLSAI KVFGYLERPV FHELTRTMQT RKLIAGETLL 250
LEEEKGFCLV VDGLVQIFVK SIQERDDDRD GWQLDEAVED SVDEDDEIRR 300
RGHQGYQLLT EVKNGASMSS LFSILSLFSE DIKLRHNEDM ESSSSSFNNV 350
PAPDSNPMSP ALLLESPTRV SFPDQRDIPT QPSADTLPKV SPLALEGSPG 400
PFEHDPKPRG HRRKRPSRPK RAKSVHPDIL ARAMVDTTIA IIPASAFRRL 450
TRVYPKATAH IIQVILTRLQ RVTFATAHSY LGLTTEVLSI EQQMTKYTSF 500
DLPNHLRGAA LDKLKSKFTK EKERLGPEDG TKGIALHNPA LNRRRRSSSS 550
LRKDAALHAK LTAVRGKGSA SNPIRYGDHE STGVSPGDLL STIQLSRFGP 600
RYGSERLNGR SVFYDAASGM KTPAGGPPSP LATPGQPLFR FPAQNVTFQR 650
QDSLDQDAIF RESILDCMMK ALGLTGSTQD ALRKTHNSGD ASPHLVSYDS 700
RRQKAVFNNA FGFIDPYDGF GDGDSESLMS MSVTSAGGTS PVHNLRTELQ 750
DEIEIVYFPK GSVLIEQGEH NPGLYYVIDG FLDVGIPVNE KGEDLIGSSR 800
RPTAEDILLP ITGNASRVSS TLGTAHNQRK KASRRSLYMV KPGGVEGYIG 850
SITSYRSFTD VTAKTDVYVG FLPRAVLERI ADRYPLVMLT MAKRLTTVLP 900
RLILHIDFAL EWVQVNAGQV IHHQGDESDA IYIVLNGRLR AVLDKGDGKV 950
SVLGEYGQGD SVGELEVMTE STRPGTLHAI RDTELAKFPR TLFNSLAQEH 1000
PGITIQISKL IAQRMRHIID NPLEKGSDKG SPDSAKPTTS TLNLRTVAVL 1050
PVTAGIPVVE FGNRLLNAFN QVGVTNGVTS LHQADILNHL GRHAFSKMGK 1100
LKLAQYLADL EERYGMVLYV GDTSVNAPWT QTCIAQADCI LLVALAEGSP 1150
AIGEYERFLL GMKTTARKEL VLLHAERYSQ PGLTRQWLKN RMWINGGHHH 1200
IQMAFRLTAE PVHPETKRLG AVLKQRVQVI QAEIQKYTSR RIRQTPVYST 1250
STPVKGDFHR LARRLCGKSV GLVLGGGGAR GIAHIGVIKA LEEAGIPIDI 1300
IGGTSIGSFI GALYARDADV VPAYGRAKKF SGRMASMWRF ALDLTYPSAS 1350
YTTGHEFNRG IFKAFGNSHI EDFWLEFYCN TTNISKSRLE FHSSGYAWRY 1400
VRASMSLAGL IPPLCDEGNM LLDGGYVDNL TVARMKSLGA DVIFAVDVGA 1450
IDDNTPQGYG DSLSGFWALV NRWNPFSSLP NPPTLSEIQA RLAYVSSVDA 1500
LERAKSTPGC LYMRPPIDAF GTLDFAKFDE IYQVGYKFGK EFLDRLKNEG 1550
GLPIQEETEE KKKLRRTMAP RRASI 1575
Length:1,575
Mass (Da):173,384
Last modified:January 9, 2013 - v3
Checksum:i1E6B773A6278AC61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704913 Genomic DNA. Translation: EAS27977.2.
RefSeqiXP_001239560.1. XM_001239559.1.

Genome annotation databases

GeneIDi4558296.
KEGGicim:CIMG_09181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704913 Genomic DNA. Translation: EAS27977.2 .
RefSeqi XP_001239560.1. XM_001239559.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4558296.
KEGGi cim:CIMG_09181.

Phylogenomic databases

OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiNTE1_COCIM
AccessioniPrimary (citable) accession number: Q1DLC7
Secondary accession number(s): J3K1S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: January 9, 2013
Last modified: February 19, 2014
This is version 52 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi