Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q1DKE7 (DNLI4_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase 4
EC=6.5.1.1
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene names
Name:LIG4
ORF Names:CIMG_09216
OrganismCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides

Protein attributes

Sequence length985 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactor

Magnesium By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Contains 2 BRCT domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 985985DNA ligase 4
PRO_0000278379

Regions

Domain711 – 80494BRCT 1
Domain878 – 983106BRCT 2

Sites

Active site3121N6-AMP-lysine intermediate By similarity
Metal binding3791Magnesium 1 Potential
Metal binding4801Magnesium 2 Potential
Binding site3101ATP By similarity
Binding site3171ATP By similarity
Binding site3391ATP By similarity
Binding site4851ATP By similarity
Binding site4961ATP By similarity
Binding site5021ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1DKE7 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: ADD8E6B21A345FEB

FASTA985112,847
        10         20         30         40         50         60 
MDRLNNVGGE TERELDEKYP NRPRNKHSTL PFHDLFLTLF NPLNGNKKRP TGPAAARKKL 

        70         80         90        100        110        120 
GPHGGQQTLS PQELRRDIIQ RFISRWRKEV GNDIYPAFRL IIPEKDRDRA MYGLKEKTIG 

       130        140        150        160        170        180 
KLLVKIMKID KNSEDGFNLL NWKLPGQSMA SRMAGDFAGR CYEVISKRPI RTDVGNMTIQ 

       190        200        210        220        230        240 
EVNDKLDVLA ATSKEDEQIP VLEEFYRNMN PEELMWLIRI ILRQMKVGAT ERTFFEIWHP 

       250        260        270        280        290        300 
DAESLFSISS SLRRVCWELY DPNVRLEADE ARVTLMQCFQ PQLAQFQMHS FPKMIERMRL 

       310        320        330        340        350        360 
SPDDPTFWIE EKLDGERIQL HMMSDDSIPG GKRFGFWSRK AKDYTYLYGN GFYDENGALT 

       370        380        390        400        410        420 
RHLKDAFADG VDNIILDGEM ITWDPEQDAP LPFGTLKTAA LSEQRNPFSA TGQRPLFRIF 

       430        440        450        460        470        480 
DILYLNDKAL TRYTLRDRRR ALEASIKPVH RRLEVHTYEI GNSAADIEPQ LRKVVAEASE 

       490        500        510        520        530        540 
GLVLKNPNSP YRLNDRHDDW MKVKPEYMTE FGESLDCVVI GGYYGSGKRG GGLASFLCGL 

       550        560        570        580        590        600 
RVDEAQVRQG ASPMKCYSFL KVGGGFTAPD YANIRHHTDG KWKDWNPKKP PTEFIELAGG 

       610        620        630        640        650        660 
DAQYERPDVW IRPDESVVLC VKAASVTPSD QFRLGLTVRF PRFKRLRMDK DWKSALSIQE 

       670        680        690        700        710        720 
FMDLKANAER EQKEKEFKID NSRRKRAKRA VKKPLTIAGY DESKRAGFTG PSGHVFEGMN 

       730        740        750        760        770        780 
FFVITDSVEP EKKSKLELEQ LIKANGGKIY QTHTAAPNTL CIAERRTVKV ASVQKVAKES 

       790        800        810        820        830        840 
IIRPSWLFDC IKQNEVDKGL PDLLIPFEPR HMYFTVKSQE EEIARHVDEY SDSYARDITP 

       850        860        870        880        890        900 
NELSKLLVSM PLIPNLPPPH ISKTETQIQE RESTFQELRG WLFKNQVLHF VKRRSDSMLS 

       910        920        930        940        950        960 
LPLRLASNLA RFAGASVANE LEDKSITHVV IDTDSQPADV SALRSAISKR VAAGRRIPHL 

       970        980 
VTIAWIQDSW KAESLLDEER FAPTA

« Hide

References

[1]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed: 19717792] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH476730 Genomic DNA. Translation: EAS28012.1.
RefSeqXP_001239595.1. XM_001239594.1.

3D structure databases

ProteinModelPortalQ1DKE7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4558489.
KEGGcim:CIMG_09216.

Family and domain databases

InterProIPR001357. BRCT.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK10777.
PfamPF00533. BRCT. 1 hit.
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMSSF52113. BRCT. 2 hits.
SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00574. Dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI4_COCIM
AccessionPrimary (citable) accession number: Q1DKE7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents