ID   FTHS_MYXXD              Reviewed;         551 AA.
AC   Q1DFW5;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Formate--tetrahydrofolate ligase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            EC=6.3.4.3 {ECO:0000255|HAMAP-Rule:MF_01543};
DE   AltName: Full=Formyltetrahydrofolate synthetase {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FHS {ECO:0000255|HAMAP-Rule:MF_01543};
DE            Short=FTHFS {ECO:0000255|HAMAP-Rule:MF_01543};
GN   Name=fhs {ECO:0000255|HAMAP-Rule:MF_01543};
GN   OrderedLocusNames=MXAN_0175;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10-
CC         formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216;
CC         EC=6.3.4.3; Evidence={ECO:0000255|HAMAP-Rule:MF_01543};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
CC   -!- SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01543}.
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DR   EMBL; CP000113; ABF87836.1; -; Genomic_DNA.
DR   RefSeq; WP_011550322.1; NC_008095.1.
DR   AlphaFoldDB; Q1DFW5; -.
DR   SMR; Q1DFW5; -.
DR   STRING; 246197.MXAN_0175; -.
DR   EnsemblBacteria; ABF87836; ABF87836; MXAN_0175.
DR   GeneID; 41357678; -.
DR   KEGG; mxa:MXAN_0175; -.
DR   eggNOG; COG2759; Bacteria.
DR   HOGENOM; CLU_003601_3_3_7; -.
DR   OrthoDB; 9761733at2; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00477; FTHFS; 1.
DR   Gene3D; 3.30.1510.10; Domain 2, N(10)-formyltetrahydrofolate synthetase; 1.
DR   Gene3D; 3.10.410.10; Formyltetrahydrofolate synthetase, domain 3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01268; FTHFS; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; One-carbon metabolism;
KW   Reference proteome.
FT   CHAIN           1..551
FT                   /note="Formate--tetrahydrofolate ligase"
FT                   /id="PRO_0000293048"
FT   BINDING         54..61
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01543"
SQ   SEQUENCE   551 AA;  58072 MW;  67F9271C23228902 CRC64;
     MTLRAMTDVG AELGLSPEDV LPWGTHRAKV SLDALGKRGG RQGRLVLVSA INPTPPGEGK
     TTMSVALAMG LRKRGRRAVA ALREPSLGPV FGVKGGGTGG GQASLEPAAD INLHFTGDLH
     AITSANNLLS ALVDNAVFYG QPVALDATRV RWRRALDMND RFLRNVIVGL GGKAQGVPRE
     DHFDITAASE VMAILALAEG LKDLEARLGR VIIGHTRDGQ PVRARDVDAA ASMVALLKDA
     LMPNLAQTRE GGPALVHAGP FANIAHGCSS VMGTRMGLAY ADEVITEAGF GFDLGAEKFL
     DIKCRGSGLW PRGVVLVVTL RALKHHGGAS PARVAEPDRE ALVRGFAHLE KHLESVAAFG
     LPAVLCVNRF PQDTESELEE LRAFGKARGV ETAVCDGFSR GGDGSLELAD CVLEMLDGTD
     AAPPQPRFLY DVAQTPEEKV AAIARTVYGA DDVAFTASAK KDLDAIRELG GAGLPVCMAK
     THLSLSDDPT KLGRPRGFTL TVREVRLSAG AGFMVALTGE ILTMPGLPRE PAARRVTVHD
     DGRVTGLMQG E
//